Abstract: The present invention relates to a proNGF mutant and to uses thereof, in particular the use of a proNGF mutant for producing human beta-NGF. The present invention discloses a method of preparing a biologically active human beta-NGF from an inactive insoluble proNGF mutant. A proNGF mutant of the invention is substituted by any amino acid but not Arg or Lys at the native protease cleavage site R1SK3R4 at least at positions R1 and K3 corresponding to positions 101 and 103 of the human wildtype proNGF sequence.

Abstract: A substrate of glass or glass ceramics having a semitransparent coating is provided. The semitransparent coating has high scratch resistance, good temperature stability, and good adhesion on a sealing layer. The coating material has at least one sol-gel-based matrix, to which colorants are added, and that a polyester-functionalized and/or an epoxy-functionalized silicone resin, such as a polyester-modified silicone resin, is added to the sol-gel-based matrix.

Abstract: A method for producing a sol-gel ink, in particular from TEOS and MTEOS, is provided. The method includes adding inorganic particles as a filler and adding a high-boiling solvent.

Abstract: The present invention relates to a proNGF mutant and to uses thereof, in particular the use of a proNGF mutant for producing human beta-NGF. The present invention discloses a method of preparing a biologically active human beta-NGF from an inactive insoluble proNGF mutant. A proNGF mutant of the invention is substituted by any amino acid but not Arg or Lys at the native protease cleavage site R1SK3R4 at least at positions R1 and K3 corresponding to positions 101 and 103 of the human wildtype proNGF sequence.

Abstract: A coating material is provided that includes a sol-gel coating system, pigments, and chain-like or fibrous nanoparticles. The coating system is stable at high temperatures and is suitable for glass or glass-ceramic substrates having a low thermal expansion coefficient.

Abstract: The invention relates to a method for producing a composite material with a decorative coating, wherein a porous layer that includes pigment particles is applied onto a glass or glass ceramic substrate. The porous layer is filled with a polymer.

Abstract: A semi-transparent coating material for coating glass or glass ceramics includes at least one sol-gel hybrid-polymer coating system having a hybrid-polymer or inorganic sol-gel-based matrix, and nanoparticles and nanoscale pigments and/or dyes are added to the hybrid-polymer or inorganic sol-gel-based matrix.

Abstract: A display device is provided that is a transparent, colored glass-ceramic with a display face on the front, an illumination face on the back, and at least one light-emitting element being disposed in the region of the illumination face. The display device further includes a color compensation filter in the form of a color layer introduced directly or indirectly on the glass ceramics.

Abstract: The invention relates to drug delivery systems comprising a water-soluble polymer matrix and a bioactive agent entrained therein, said water soluble polymer matrix containing at least 50 wt. % of polyoxazoline having a molar mass of at least 5 40,000 g/mol. The drug delivery systems of the present invention offer the advantage that the bioactive agent is readily released when the drug delivery system is contacted with water. The drug delivery system can be in the form of a solid dispersion, a mucoadhesive sheet, a tablet, a powder, a capsule.

Abstract: A product having a glass or glass-ceramic substrate is provided. The substrate is exposable to temperatures in a range of up to 700° C. and has, at least on one surface, a self-cleaning and/or dirt-repellent layer for improving cleanability. The layer is high-temperature resistant, as well as resistant to mechanical stresses. The layer includes at least one of the metal oxides of elements Hf, Y, Zr, or Ce in an at least partially nanocrystalline structure as a basic material, and at least one further metal cation of any of elements Ca, Ce, Y, K, Li, Mg, Sr, and Gd.

Abstract: Disclosed are articles that are provided with a haptically-perceptible surface. The articles include a coated glass or glass ceramic substrate which is provided with a layer with haptic properties so that the layer has a haptically perceptible texture. The layer includes texturing inorganic and/or polysiloxane-based particles which are fixed on the substrate by a layer-forming material. The particles cause protrusions on the layer and so produce the haptically perceptible texture.

Abstract: The invention relates to a method for producing folded prethrombin, wherein inclusion bodies, which contain unfolded prethrombin or a derivative thereof, are solubilized in a solubilization buffer containing at least one chaotropic compound and at least one organic disulfide compound. The invention further relates to methods for producing thrombin and a-thrombin and derivatives thereof. The invention also relates to solutions that contain folded proteins, which can be produced by the methods according to the invention.

Abstract: A method for producing a pane of a household appliance or a viewing window of an oven is provided. The method includes the steps of: providing a substrate; applying a sol-gel layer to the substrate; embossing a haptically perceptible pattern using an embossing tool in the sol-gel layer; and curing the sol-gel layer. A pane of a household appliance or piece of furniture is also provided that includes a glass or glass-ceramic substrate with a patterned sol-gel layer which has a haptically perceptible pattern.

Abstract: In order to provide a decorative coating (9) which exhibits improved temperature resistance and strength on glass and glass-ceramic and which also has no strength-reducing effect on the substrate (3), or at least no longer has any substantially strength-reducing effect on the substrate, the invention envisions a process for producing glass or glass-ceramic articles having a decorative layer in which at least one decorative pigment (13) is mixed with a sol-gel binder (11), and the pigment mixed with the sol-gel binder is cured on the glass or glass-ceramic substrate of the article by annealing, to form a decorative layer having a porous ceramiclike structure.

Abstract: The invention relates to drug delivery systems comprising a water-soluble polymer matrix and a bioactive agent entrained therein, said water soluble polymer matrix containing at least 50 wt. % of polyoxazoline having a molar mass of at least 5 40,000 g/mol. The drug delivery systems of the present invention offer the advantage that the bioactive agent is readily released when the drug delivery system is contacted with water. The drug delivery system can be in the form of a solid dispersion, a mucoadhesive sheet, a tablet, a powder, a capsule.

Abstract: The invention relates to the production and use of a gray hue palette for decorative coatings based on a sol-gel method for glass and glass-ceramic articles, wherein flake-form pigments and solid lubricant are used in specific mass ratios as decorative pigments. The pigmentation provides a high-temperature-stable decorative layer, has good adhesive strength between the substrate and the decorative layer, has good impermeability relative to fluids and gases during use, as well as a high resistance to scratching. The invention further relates to glass or glass-ceramic articles with decorative coatings which are produced, in particular, according to the method of the invention, which are suitable particularly for use as glass-ceramic cooktops due to the named good layer properties of the decorative layer.

Abstract: The invention relates to a method for producing a glass or glass-ceramic article, comprising a decorative layer and a sealing layer. The two layers are produced by means of a sol-gel process and contain, in addition, at least fillers and inorganic pigments, wherein it is possible for the pigmentation of the decorative layer and the sealing layer to be the same or else different. In order to achieve a good adhesive strength and impermeability of the decorative coating, certain composition rules in regard to the quantity and kind of inorganic pigments used must be observed and, surprisingly, are different for the sealing layer according to the invention than for the decorative layer. The invention relates, furthermore, to a glass or glass-ceramic article with decorative coatings, produced particularly according to the method of the invention, said article being suitable especially for use as glass-ceramic cooktops.

Abstract: In order to provide a decorative coating (9) which exhibits improved temperature resistance and strength on glass and glass-ceramic and which also has no strength-reducing effect on the substrate (3), or at least no longer has any substantially strength-reducing effect on the substrate, the invention envisions a process for producing glass or glass-ceramic articles having a decorative layer in which at least one decorative pigment (13) is mixed with a sol-gel binder (11), and the pigment mixed with the sol-gel binder is cured on the glass or glass-ceramic substrate of the article by annealing, to form a decorative layer having a porous ceramiclike structure.

Abstract: A transparent, colorless glass or glass-ceramic panel has a visually dense, high-temperature-stable coating having an organic/inorganic network structure containing filling material particles and a color-imparting pigment. The mechanically stable, visually dense coating has no melt-reaction zone at the surface of the panel, which is coated with the coating, so that it does not impair the panel strength. The inorganic network structure can be made from a SiO2-based sol. The coating is made by introducing the color-imparting pigment and the filling material particles into a reactive organic/inorganic network structure; applying the resulting organic/inorganic network structure containing the pigment and the filling material particles to the panel to coat the panel and then burning-in the organic/inorganic network structure with the pigment and the filling material particles under thermal conditions to form the coating with no melt-reaction zone.

Abstract: A transparent, colorless glass or glass-ceramic panel has a visually dense, high-temperature-stable coating having an organic/inorganic network structure containing filling material particles and a color-imparting pigment. The mechanically stable, visually dense coating has no melt-reaction zone at the surface of the panel, which is coated with the coating, so that it does not impair the panel strength. The inorganic network structure can be made from a SiO2-based sol. The coating is made by introducing the color-imparting pigment and the filling material particles into a reactive organic/inorganic network structure; applying the resulting organic/inorganic network structure containing the pigment and the filling material particles to the panel to coat the panel and then burning-in the organic/inorganic network structure with the pigment and the filling material particles under thermal conditions to form the coating with no melt-reaction zone.