Patents by Inventor Andreas Bachmair

Andreas Bachmair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of generating desired amino-terminal residues in peptides
    Patent number: 5847097
    Abstract: Methods of designing or modifying protein structure at the protein or genetic level to produce specified amino-termini in vivo or in vitro are described. The methods can be used to alter the metabolic stability and other properties of the protein or, alternatively, to artificially generate authentic amino-termini in proteins produced through artificial means. The methods are based upon the introduction of the use of artificial ubiquitin-protein fusions, and the discovery that the in vivo half-life of a protein is a function of the amino-terminal amino acid of the protein.
    Type: Grant
    Filed: December 14, 1995
    Date of Patent: December 8, 1998
    Assignee: Massachusetts Institute of Technology
    Inventors: Andreas Bachmair, Daniel Finley, Alexander Varshavsky
  • Methods of generating desired amino-terminal residues in proteins
    Patent number: 5646017
    Abstract: Methods of designing or modifying protein structure at the protein or genetic level to produce specified amino-termini in vivo or in vitro are described. The methods can be used to alter the metabolic stability and other properties of the protein or, alternatively, to artificially generate authentic amino-termini in proteins produced through artificial means. The methods are based upon the introduction of the use of artificial ubiquitin-protein fusions, and the discovery that the in vivo half-life of a protein is a function of the amino-terminal amino acid of the protein.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 8, 1997
    Assignee: Massachusetts Institute of Technology
    Inventors: Andreas Bachmair, Daniel Finley, Alexander Varshavsky
  • Methods of generating desired amino-terminal residues in proteins
    Patent number: 5496721
    Abstract: Methods of designing or modifying protein structure at the protein or genetic level to produce specified amino-termini in vivo or in vitro are described. The methods can be used to alter the metabolic stability and other properties of the protein or, alternatively, to artificially generate authentic amino-termini in proteins produced through artificial means. The methods are based upon the introduction of the use of artificial ubiquitin-protein fusions, and the discovery that the in vivo half-life of a protein is a function of the amino-terminal amino acid of the protein.
    Type: Grant
    Filed: May 9, 1994
    Date of Patent: March 5, 1996
    Assignee: Massachusetts Institute of Technology
    Inventors: Andreas Bachmair, Daniel Finley, Alexander Varshavsky
  • Methods for in vitro cleavage of ubiquitin fusion proteins
    Patent number: 5196321
    Abstract: Methods of designing or modifying protein structure at the protein or genetic level to produce specified amino-termini in vivo or in vitro are described. The methods can be used to alter the metabolic stability and other properties of the protein or, alternatively, to artificially generate authentic amino-termini in proteins produced through artificial means. The methods are based upon the introduction of the use of artificial ubiquitin-protein fusions, and the discovery that the in vivo half-life of a protein is a function of the amino-terminal amino acid of the protein.
    Type: Grant
    Filed: January 15, 1992
    Date of Patent: March 23, 1993
    Assignee: Massachusetts Institute of Technology
    Inventors: Andreas Bachmair, Daniel Finley, Alexander Varshavsky
  • Method for producing proteins and polypeptides using ubiquitin fusions
    Patent number: 5132213
    Abstract: A method of designing or modifying protein structure at the protein or genetic level to produce specified amino-termini in vivo is described. The method is used to alter the metabolic stability and other properties of the protein or, alternatively, to artificially generate authentic amino-termini in proteins produced through artificial means. The method is based upon the introduction of the use of artificial ubiquitin-protein fusions, and the discovery that the in vivo half-life of a protein is a function of the amino-terminal amino acid of the protein.
    Type: Grant
    Filed: April 7, 1988
    Date of Patent: July 21, 1992
    Assignee: Massachusetts Institute of Technology
    Inventors: Andreas Bachmair, Daniel Finley, Alexander Varshavsky
  • Methods of generating desired amino-terminal residues in proteins
    Patent number: 5093242
    Abstract: A method of designing or modifying protein structure at the protein or genetic level to produce specified amino-termini in vivo are described. The method can be used to alter the metabolic stability and other properties of the protein or, alternatively, to artificially generate authentic amino-termini in proteins produced through artificial means. The method is based upon the introduction of the use of artificial ubiquitin-protein fusions, and the discovery that the in vivo half-life of a protein is a function of the amino-terminal amino acid of the protein.
    Type: Grant
    Filed: May 24, 1989
    Date of Patent: March 3, 1992
    Assignee: Massachusetts Institute of Technology
    Inventors: Andreas Bachmair, Daniel Finley, Alexander Varshavsky