Abstract: The invention is based on a platform for vaccination and/or antibody generation. The invention is based on the display of small molecular immunogenic compounds on the coat of variant surface glycoproteins (VSG) on trypanosomes which results in a highly effective immune response when used as a vaccine or in immunization for antibody production. The herein disclosed antigenic particles are applicable for producing antibodies or can be directly used as vaccines for the treatment of various medical conditions. Most preferably the invention relates to the VSG based vaccines specific for dependency causing substances for the treatment of addiction or avoidance of adverse events during drug abuse. Other applications include methods and uses involving the disclosed compounds and compositions for a treatment or prevention of cancer, infectious disease, contagious neurodegenerative diseases, non-communicable disorders (e.g.

Abstract: A metering device serves as an equipping or retrofitting kit for a device for producing a three-dimensional object by means of solidifying, layer by layer, a building material in powder form at those positions that correspond to the cross-section of the object to be produced in the respective layer. The metering device has a metering element, which metering element is rotatable about an axis, preferably an axis of its own, particularly preferably about an, in particular its own, longitudinal axis and which is suitable for dispensing the building material in powder form in a metered manner. The metering element is designed to dispense locally different amounts of powder along the direction of the axis.

Abstract: A stretching-shaft screening device for separating insects, in particular insect larvae, or worms and residual material, is disclosed, having a screen that has a first screening portion and an adjoining second screening portion, wherein the mesh size in the first screening portion is smaller than the mesh size in the second screening portion. The invention also relates to the use of a stretching-shaft screening device for separating insects, in particular insect larvae, or worms and residual material.

Abstract: A method of manufacturing an object (3) in a build area (22) by means of a successive layer-by-layer solidification of a building material in powder form (18) comprises the steps: a) applying a layer of the building material in powder form (18) having a predetermined thickness d2 onto a layer of the building material already previously applied which has been solidified in a region corresponding to a cross section of the object (3), wherein, for applying the building material (18), a recoater (5, 15) is moved in a direction (B) across the layer already previously applied, and b) selectively solidifying the building material (18) applied in step a) in a region corresponding to a cross section of the object (3), wherein, prior to the application of a layer, for a solidified region having a thickness d1 in the layer applied before, the maximum (MAX) of the product of the extension of this solidified region in movement direction (B) of the recoater (5) and the thickness d1 is determined and during the applicati

Abstract: A method of manufacturing an object comprises applying a layer of building material in powder form having a predetermined thickness onto a layer of the building material already previously applied which has been solidified in a region corresponding to a cross section of the object. A recoater is moved in a direction across the layer already previously applied, and the building material is solidified in a shape corresponding to a cross section of the object. Prior to the application of a layer, for a solidified region having a thickness in the layer applied before, the maximum of the product of the extension of this region in movement direction of the recoater and the thickness is determined and during the application of the layer, at least an additional powder amount proportional to the value of the maximum is additionally provided.

Abstract: The invention is based on a platform for vaccination and/or antibody generation. The invention is based on the display of small molecular immunogenic compounds on the coat of variant surface glycoproteins (VSG) on trypanosomes which results in a highly effective immune response when used as a vaccine or in immunization for antibody production. The herein disclosed antigenic particles are applicable for producing antibodies or can be directly used as vaccines for the treatment of various medical conditions. Most preferably the invention relates to the VSG based vaccines specific for dependency causing substances for the treatment of addiction or avoidance of adverse events during drug abuse. Other applications include methods and uses involving the disclosed compounds and compositions for a treatment or prevention of cancer, infectious disease, contagious neurodegenerative diseases, non-communicable disorders (e.g.

Abstract: A method of manufacturing a three-dimensional object by a layer-by-layer application and selective solidification of a building material by exposure to a radiation. A hollow body is arranged in a process chamber above a build area which hollow body substantially extends from the build area in a direction of an upper side of the wall of the process chamber. Gas is supplied to the process chamber in such a manner and gas is discharged from the process chamber in such a manner that a lower pressure exists in the region of the process chamber lying within the hollow body than in the region of the process chamber lying outside the hollow body.

Abstract: After the manufacturing of an object by layer-wise solidification from a powder, this object is displaced into a container together with the powder surrounding the object, and is closed by a plate, which is positioned below the object during the manufacturing of the object.

Abstract: A metering device serves as an equipping or retrofitting kit for a device for producing a three-dimensional object by means of solidifying, layer by layer, a building material in powder form at those positions that correspond to the cross-section of the object to be produced in the respective layer. The metering device has a metering element, which metering element is rotatable about an axis, preferably an axis of its own, particularly preferably about an, in particular its own, longitudinal axis and which is suitable for dispensing the building material in powder form in a metered manner. The metering element is designed to dispense locally different amounts of powder along the direction of the axis.

Abstract: A method of manufacturing a three-dimensional object by a layer-by-layer application and selective solidification of a building material by exposure to a radiation. A hollow body is arranged in a process chamber above a build area which hollow body substantially extends from the build area in a direction of an upper side of the wall of the process chamber. Gas is supplied to the process chamber in such a manner and gas is discharged from the process chamber in such a manner that a lower pressure exists in the region of the process chamber lying within the hollow body than in the region of the process chamber lying outside the hollow body.

Abstract: A method of manufacturing an object in a build area by successive layer-by-layer solidification of a building material in powder form. The method includes applying a layer of the building material in powder form having a predetermined thickness onto a layer of the building material already previously applied which has been solidified in a region corresponding to a cross section of the object A recoater is moved in a direction across the layer already previously applied, and the building material is solidified in a shape corresponding to a cross section of the object. Prior to the application of a layer, for a solidified region having a thickness d1 in the layer applied before, the maximum of the product of the extension of this region in movement direction of the recoater and the thickness d1 is determined and during the application of the layer, at least an additional powder amount proportional to the value of the maximum is additionally provided.

Abstract: The present invention relates to a device for generatively manufacturing a three-dimensional object (3), comprising: a frame (1) defining a building field (6) at an upper portion (2) thereof; a plate (12) which connects the frame (1) with a housing (100) of the device; a support (5) which is arranged in the frame (1) and vertically movable by a lift mechanics (4) at least below the building field (6); a radiation device (7) which generates an energetic beam (8, 8?) which is focused by a deflection means (9) to arbitrary points in the building field (6), so as to selectively sinter or melt a powdery material (11) which is present in the building field (6); a coater (10) for applying a layer of powdery material (11) onto the support (5) or a previously applied layer of the powdery material (11). A thermal insulation (13) is arranged between the frame (1) and the plate.

Abstract: In a self-propelling road construction machine, particularly a road roller (1), comprising a travel drive, a steering device, a control device (30) for the travel drive and the steering device, and a driver's seat (5) rotatable by at least 180° and including an integrated operating element (8) for the vehicle speed, with the operating element (8) generating the control signals for the travel drive in dependence on the direction of the control movement of the operating element (8) or the direction of force application on the operating element (8), it is provided that, in response to a first switching command, the control device (30) will automatically perform a reversing process comprising deceleration, seat rotation, change of direction of travel, and acceleration to the set vehicle speed in opposite direction to the original direction of travel.

Abstract: The present invention relates to a device for generatively manufacturing a three-dimensional object (3), comprising: a frame (1) defining a building field (6) at an upper portion (2) thereof; a plate (12) which connects the frame (1) with a housing (100) of the device; a support (5) which is arranged in the frame (1) and vertically movable by a lift mechanics (4) at least below the building field (6); a radiation device (7) which generates an energetic beam (8, 8?) which is focused by a deflection means (9) to arbitrary points in the building field (6), so as to selectively sinter or melt a powdery material (11) which is present in the building field (6); a coater (10) for applying a layer of powdery material (11) onto the support (5) or a previously applied layer of the powdery material (11). A thermal insulation (13) is arranged between the frame (1) and the plate.

Abstract: The monitoring of complex or spacious buildings or spaces requires a multiplicity of monitoring devices, for example monitoring cameras, in order to be able to extensively cover such monitoring areas. For this purpose, the invention proposes a terminal 7 having at least one functional device, wherein the functional device is in the form of a sensor and/or actuator device, having a control device 10, wherein the control device 10 is in the form of a digital data processing device, and having at least one network interface 9, wherein the network interface 9 is designed to couple the control device 10 to a network 2, with the result that data can be transmitted from the functional device to the network 2 and/or data can be transmitted from the network 2 to the functional device. The terminal 7 has a client address from a first network 2 as the network, and the terminal 7 has a storage device 11 which stores a server address from a different network 4.

Abstract: The invention relates to a safety reporting network 1 having a local area monitoring network 2 for a monitoring object 3, wherein the at least one local area monitoring network 2 has at least one monitoring camera 7, wherein the monitoring camera 7 is designed to output an event notice E, having a first network 5 and a central safety control device 13, wherein the local area monitoring network 2 is connected to the central safety control device 13 via the first network 5 for the purpose of data interchange, wherein the event notice E is transmitted to the central safety control device 13 via the first network 5, having a second network 18 and at least one agent device 19 that is connected to the central safety control device 13 via the second network 18, wherein the event notice E or an event notice E? processed on the basis of the event notice is transmitted to the agent device 19 as an alarm notice A, wherein the safety reporting network 1 has a plurality of local area monitoring networks 2, wherein the plu

Abstract: The monitoring of complex or spacious buildings or spaces requires a multiplicity of monitoring devices, for example monitoring cameras, in order to be able to extensively cover such monitoring areas. For this purpose, the invention proposes a terminal 7 having at least one functional device, wherein the functional device is in the form of a sensor and/or actuator device, having a control device 10, wherein the control device 10 is in the form of a digital data processing device, and having at least one network interface 9, wherein the network interface 9 is designed to couple the control device 10 to a network 2, with the result that data can be transmitted from the functional device to the network 2 and/or data can be transmitted from the network 2 to the functional device. The terminal 7 has a client address from a first network 2 as the network, and the terminal 7 has a storage device 11 which stores a server address from a different network 4.

Abstract: After the manufacturing of an object by layer-wise solidification from a powder, this object is displaced into a container together with the powder surrounding the object, and is closed by a plate, which is positioned below the object during the manufacturing of the object.

Abstract: In a self-propelling road construction machine, particularly a road roller (1), comprising a travel drive, a steering device, a control device (30) for the travel drive and the steering device, and a driver's seat (5) rotatable by at least 180° and including an integrated operating element (8) for the vehicle speed, with the operating element (8) generating the control signals for the travel drive in dependence on the direction of the control movement of the operating element (8) or the direction of force application on the operating element (8), it is provided that, in response to a first switching command, the control device (30) will automatically perform a reversing process comprising deceleration, seat rotation, change of direction of travel, and acceleration to the set vehicle speed in opposite direction to the original direction of travel.

Abstract: A method is provided for diagnosing the operability of fuel vapor intermediate stores (4), in particular of activated carbon filters, in tank-venting systems with at least one tank (3) and at least one fuel vapor intermediate store (4). In this case an actual change degree of filling of the fuel vapor intermediate store (4) is determined as a consequence of absorption or desorption processes of gaseous hydrocarbons in the fuel vapor intermediate store (4). The actual change in degree of filling is compared with a desired change in degree of filling and, from the comparison, a conclusion about the operability of the fuel vapor intermediate store (4) is drawn.