Abstract: The present invention is directed to 4-methylumbelliferone (hymecromone) or a derivative thereof for use in the treatment of major depressive disorder, mood disorders, anxiety-related disorders and depression associated with diseases or drug treatments including Alzheimer's disease, HIV associated neurocognitive disorders (HAND), psoriasis, chronic fatigue syndrome, Parkinson's disease, Long COVID syndrome and drug treatment regimens with IFN-alpha or vitamin A analogues, promoted by pathogenic extracellular vesicles, wherein 4-methylumbelliferone inhibits hyaluronic acid (HA) synthases and block the incorporation of HA and/or low molecular weight cleavage products into said extracellular vesicles. The present invention is also directed to a method for monitoring the efficacy of the treatment and delivery of therapeutic cargo to cells incorporating pEV by means of HA-binding receptors. The present invention further provides an in vitro screening method for identifying further inhibitors of HA synthases.

Abstract: Methods and system for piece level tracking in a freight context. In one aspect, a freight tracking system includes a freight logistics computing device comprising a processor executing instructions stored in memory. The instructions cause the processer to receive an order for shipping goods in bulk at a goods level, wherein the order is associated with a plurality of pieces, define a rules engine which is configured to enable or disable piece level tracking, track at least one piece of the plurality of pieces at a piece level when piece level tracking is enabled, and expose a record providing piece level information including when the at least one piece contains different information from at least one other piece of the plurality of pieces.

Abstract: The present invention relates to a method for in vitro detection and/or monitoring of a disease in a sample, based on measurement of enzymatic activity of proteases activated and secreted upon disease development, to modified peptides used for the enzymatic detection of the proteases, the use of the peptides, a kit comprising such peptides and the use of ADAM-protease activity as a surrogate marker for disease burden and activity in infectious, inflammatory, and malignant diseases, such as HIV infection and melanoma.

Abstract: The present invention relates to a method for in vitro detection and/or monitoring of a disease in a sample, based on measurement of enzymatic activity of proteases activated and secreted upon disease development, to modified peptides used for the enzymatic detection of the proteases, the use of the peptides, a kit comprising such peptides and the use of ADAM-protease activity as a surrogate marker for disease burden and activity in infectious, inflammatory, and malignant diseases, such as HIV infection and melanoma.

Abstract: A cushion for a vehicle seat has a cushion layer arrangement that is covered by a cushion cover. The cushion layer arrangement includes an air-conducting cushion layer into which air can enter via at least one air inlet and from which the air, after flowing through it, can exit via at least one air outlet which is assigned at least one air outlet opening. At least one air outlet opening is arranged within the cushion cover.

Abstract: The invention relates to an airbag module for motor vehicles comprising a housing for a folded together inflatable air bag and a holder element which can be locked to the housing, with the holder element extending in the locked state with at least one holder section through the side wall of the housing in the region of a lug of the side wall which can be bent aside relative to the side wall.

Abstract: Pharmaceutical compositions containing at least one compound of Formula I, ##STR1## where X is a hydrogen atom or both X's represent a direct link between the two sulphur atoms; Y is hydrogen or C.sub.1 -C.sub.6 alkyl and n represents a number from 1 to 10, or their pharmaceutically acceptable salts including .alpha.-lipoic acid and dihydrolipoic acid. The pharmaceutical compositions are useful for the treatment of diseases caused by retroviruses.

Abstract: A method for the manufacture of a horseshoe is described, which is characterized in that firstly individual hoof dimensions are directly measured on the hoof and taken into account during manufacture in such a way that by an automatic control system a horseshoe is worked from a solid material and is ready for fitting to the hoof without any reworking or adaptation deformation being necessary.