Patents by Inventor Andreas Bertogg

Andreas Bertogg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of condensed imidazolo derivatives
    Patent number: 10556869
    Abstract: The present invention relates to a process for providing the compound of formula I, comprising the step of reacting a compound of formula VII with a base in the presence of an alkaline- or alkaline earth metal salt (MX), wherein LG is a leaving group. The presence of an alkaline- or alkaline earth metal salt was surprisingly found to render said reaction highly reliable in terms of the yield and purity of the compound of formula I obtained. In a further aspect, the present invention relates to the compound of formula I, having less than an amount of 1.50% or less than an amount of 1.25% or less than an amount of 1.00% or less than an amount of 0.75% or less than an amount of 0.50% or less than an amount of 0.25% or less than an amount of 0.10% of the compound of formula VIII.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: February 11, 2020
    Assignee: Novartis AG
    Inventors: Andreas Bertogg, Hanspeter Schilling
  • PROCESS FOR THE PRODUCTION OF CONDENSED IMIDAZOLO DERIVATIVES
    Publication number: 20180002292
    Abstract: The present invention relates to a process for providing the compound of formula I, comprising the step of reacting a compound of formula VII with a base in the presence of an alkaline- or alkaline earth metal salt (MX), wherein LG is a leaving group. The presence of an alkaline- or alkaline earth metal salt was surprisingly found to render said reaction highly reliable in terms of the yield and purity of the compound of formula I obtained. In a further aspect, the present invention relates to the compound of formula I, having less than an amount of 1.50% or less than an amount of 1.25% or less than an amount of 1.00% or less than an amount of 0.75% or less than an amount of 0.50% or less than an amount of 0.25% or less than an amount of 0.10% of the compound of formula VIII.
    Type: Application
    Filed: January 28, 2016
    Publication date: January 4, 2018
    Inventors: Andreas BERTOGG, Hanspeter SCHILLING
  • Demethylation of 14-hydroxy substituted alkaloid derivatives
    Patent number: 8158793
    Abstract: The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5-epoxymorphinane-6-on-derivatives. This is achieved by reacting a starting compound with a compound of general formula R1OOC—N?N—COOR2 in a suitable solvent.
    Type: Grant
    Filed: November 24, 2008
    Date of Patent: April 17, 2012
    Assignee: Siegfried Ltd.
    Inventors: Erik Heinz Lauterbach, Thomas Dinkel, Sabrina Heller, Andreas Bertogg
  • Demethylation of 14-hydroxy substituted alkaloid derivatives
    Publication number: 20090163717
    Abstract: The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5-epoxymorphinane-6-on-derivatives. This is achieved by reacting a starting compound with a compound of general formula R1OOC—N?N—COOR2 in a suitable solvent.
    Type: Application
    Filed: November 24, 2008
    Publication date: June 25, 2009
    Inventors: Erik Heinz Lauterbach, Thomas Dinkel, Sabrina Heller, Andreas Bertogg