Abstract: A handling device (1) for tubular or elongate bowl-shaped workpieces such as pipette tips (4) or cups, said workpieces preferably being transported or being able to be transported on a workpiece carrier (T) during the production of said workpieces until packaging, the workpiece carrier (T) having receiving places (5) for the workpieces, which receiving places are arranged in a grid relative to each other, preferably with the stipulation that faulty workpieces located on the workpiece carrier (T) can be detected, and preferably with the stipulation that a removal station (25) is provided, by means of which the faulty workpieces can be removed from the receiving places (5) of a workpiece carrier (T), receiving places (5) thus being freed up, freed-up receiving places (5) of the workpiece carrier (T) being able to be loaded with faultless workpieces by means of the handling device, the handling device comprising a refill magazine (2), which has magazine places (3) arranged next to each other, each magazine place

Abstract: The present invention provides compounds and pharmaceutical compositions including the compounds for the treatment of a skin disease associated with proteolytic activity of one or more KLK proteases, wherein the compounds are according to formula (I): wherein R is as described herein.

Abstract: The present invention provides compounds and pharmaceutical compositions including the compounds for the treatment of a skin disease associated with proteolytic activity of one or more KLK proteases, wherein the compounds are according to formula (I): wherein R is as described herein.

Abstract: The invention relates to an alloy, in particular a light metal alloy, having an alloy composition with at least three components and a eutectic structure that is obtained by cooling the alloy from a liquid state to a solid state, under the condition that a composition of the alloy lies in a field around a pseudoeutectic point (pE) of a phase diagram of the alloy, so that at least 85 mol % eutectic structure is present in the alloy. The alloy also relates to a method for producing an alloy of this type.

Abstract: The invention relates to a magnesium alloy. To obtain a magnesium alloy which exhibits both a high strength and also a high deformability, a magnesium alloy is provided according to the invention, comprising (in at %) 15.0% to 70.0% lithium, greater than 0.0% aluminum, and magnesium and production-related impurities as a remainder, wherein a ratio of aluminum to magnesium (in at %) is 1:6 to 4:6. The invention also relates to a method for producing the magnesium alloy.

Abstract: A method and a device for separating shirred casing sticks, where a row R1 with a first number of consecutively disposed shined casing sticks in a shined casing stick storage is pushed in a first stroke cycle by a pusher along a sloped plane in the direction of a separation edge and one after the other over the separation edge and, once the last shined casing stick of the row has been pushed over the separation edge, the pusher moves back along the sloped plane and takes a row R2 with a second number of consecutively disposed shined casing sticks and pushes them in a further stroke cycle in the direction towards the separation edge, characterized in that a control device determines the filling level of shined casing sticks in the shined casing stick storage from the number of shined casing sticks pushed over the separation edge.

Abstract: The invention relates to a method for increasing a corrosion resistance of a component formed with a magnesium-based alloy against galvanic corrosion, in particular micro-galvanic corrosion. According to the invention, an increase in a corrosion resistance against galvanic corrosion is achieved in a simple manner in that a surface layer of the component having a predefined thickness, which surface layer is formed with the magnesium-based alloy, is heated in order to configure the surface layer with a homogenized solid solution phase, whereupon the surface layer is cooled such that the surface layer is formed with a supersaturated solid solution phase. The invention furthermore relates to a corrosion-resistant component which is obtainable by a method of this type.

Abstract: The present invention provides compounds and pharmaceutical compositions including the compounds for the treatment of a skin disease associated with proteolytic activity of one or more KLK proteases, wherein the compounds are according to formula (I): wherein R is as described herein.

Abstract: A method and a device for separating shirred casing sticks, where a row R1 with a first number of consecutively disposed shined casing sticks in a shined casing stick storage is pushed in a first stroke cycle by a pusher along a sloped plane in the direction of a separation edge and one after the other over the separation edge and, once the last shined casing stick of the row has been pushed over the separation edge, the pusher moves back along the sloped plane and takes a row R2 with a second number of consecutively disposed shined casing sticks and pushes them in a further stroke cycle in the direction towards the separation edge, characterized in that a control device determines the filling level of shined casing sticks in the shined casing stick storage from the number of shined casing sticks pushed over the separation edge.

Abstract: The present disclosure relates to a method and a device for filling of sausage sleeves with pasty material through a filling tube, wherein the pasty material is fed in the filling tube through an opening on its rear end in the axial direction. At the end of the filling process, the filling tube is moved back out of its filling position in the axial direction onto an axially arranged closing element, wherein the opening is closed.

Abstract: Quantum information processing apparatus and methods are described. The apparatus comprises a device for defining a qubit and a reflectometry circuit for reading out a state of the qubit. The device comprises a semiconductor nanowire extending along a first direction having first and second obtuse or acute edges running along the first direction, gate dielectric overlying the first and second edges of the nanowire and a split gate running across a section of the nanowire in a second, transverse direction, the split gate comprising first and second gates overlying the first and second edges respectively. The reflectometry circuit comprises a resonator coupled to the first or second gate.

Abstract: The present disclosure relates to a method and a device for filling of sausage sleeves with pasty material through a filling tube, wherein the pasty material is fed in the filling tube through an opening on its rear end in the axial direction. At the end of the filling process, the filling tube is moved back out of its filling position in the axial direction onto an axially arranged closing element, wherein the opening is closed.

Abstract: Quantum information processing apparatus and methods are described. The apparatus comprises a device for defining a qubit and a reflectometry circuit for reading out a state of the qubit. The device comprises a semiconductor nanowire extending along a first direction having first and second obtuse or acute edges running along the first direction, gate dielectric overlying the first and second edges of the nanowire and a split gate running across a section of the nanowire in a second, transverse direction, the split gate comprising first and second gates overlying the first and second edges respectively. The reflectometry circuit comprises a resonator coupled to the first or second gate.

Abstract: A computer-implemented method is made available for processing a character string for a graphical representation on a man/machine interface, wherein each character of the character string is represented by a glyph saved in a font library. The glyph assigned to each character provides at least one outline for the character. The method comprises the steps of retrieving at least the outline of each character of the character string from the font library, generating, on the basis of the retrieved outlines, a single path object representing the character string, which comprises at least the outlines of all the characters of the character string, and transferring the path object to a graphics interface for the purpose of graphical representation of the path object. Furthermore, a module for implementing the method is specified.

Abstract: A filling machine for sausages, having a filling tube and a unit for removing a filling material plait exiting the filling tube end during a filling process interruption, where the removing unit includes a separator element by means of which the filling material plait can be removed when a relative movement is executed between the filling tube end and the separator element, the separator element including at least one filling material adhesion surface to which filling material is transferable and adherable, and the adhesion surface has associated therewith a cleaning device.

Abstract: A stuffing tube centering device for concentric alignment of the stuffing tube to a casing stick and a corresponding method, and where two oppositely disposed centering members movable towards each other between which the stuffing tube can be held and centered.

Abstract: A filling machine for sausages, having a filling tube and a unit for removing a filling material plait exiting the filling tube end during a filling process interruption, where the removing unit includes a separator element by means of which the filling material plait can be removed when a relative movement is executed between the filling tube end and the separator element, the separator element including at least one filling material adhesion surface to which filling material is transferable and adherable, and the adhesion surface has associated therewith a cleaning device.

Abstract: A stuffing tube centering device for concentric alignment of the stuffing tube to a casing stick and a corresponding method, and where two oppositely disposed centering members movable towards each other between which the stuffing tube can be held and centered.

Abstract: The present invention relates to a method for identifying and/or obtaining a molecule which is capable of modifying secretion processes comprising the steps of a) contacting an unc-13 molecule or (a) part(s) or (a) fragment(s) thereof with a candidate molecule; b) measuring and/or detecting a response; and c) comparing said response to a standard response as measured in the absence of said candidate molecule. Furthermore, a method for identifying and/or obtaining a isoform-specific modulator of isoform-specific Munc13 activity is disclosed. The invention also provides for pharmaceutical and diagnostic compositions as well as for uses of antagonist or agonists as identified and/or obtained by the inventive method for the preparation of pharmaceutical and diagnostic compositions.