Abstract: The invention relates to a composition containing, as active ingredient, ectoine, hydroxyectoine and/or salts, esters or amides of these compounds for the treatment and/or prophylaxis of diseases of the eye that are associated with a disturbance of the tear film. The disease can be in particular a keratoconjunctivitis sicca. It has been found that, surprisingly, these compounds are capable of preventing a rupture in the outer lipid layer of the tear film, avoiding an undesirably rapid evaporation of the lacrimal fluid.

Abstract: The invention relates to a composition containing as active agent ectoine, hydroxyectoine, glucosylglycerol and/or salts, esters or amides of these compounds for promoting the regeneration of injured body tissue. The invention has special significance for the treatment of chronic wounds or ulcers.

Abstract: A method for increased and permanent production of a natural compound by a microorganism during an exponential growth and during a stationary phase of a culture of the microorganism, the method comprising: enhancing a translation of a target mRNA, wherein the target mRNA comprises a transcript of a target gene, wherein the target gene is encoding the natural compound or a key enzyme involved in a biosynthesis of the natural compound in the microorganism, by replacing a wild type (wt) ribosome binding site (RBS) upstream of the target gene with a synthetic RBS, the synthetic RBS possessing a higher affinity towards a 16S rRNA of a ribosome of the microorganism than the wt RBS; and enhancing a transcription of the target gene by converting an osmotically regulated ?38 promoter upstream of the target gene into a stationary ?38 promoter, wherein the osmotically regulated ?38 promoter comprises a ?35 G-element and a ?10 element which are separated from each other by a spacer sequence, by deleting the ?35 G elem

Abstract: The invention relates to a compatible solute or a solute mixture, as well as to a composition comprising the solute or solute mixture, for use in the prevention or treatment of cosmetic or pathologic efflorescences caused by airborne particles, such as pigmentation accompanying with skin ageing, and de- or hypopigmentation, hyperpigmentation, as well as alterations accompanying with atrophy in the broadest sense.

Abstract: The invention relates to a composition containing N-acetyldiaminobutyric acid, a salt or an ester of N-acetyldiaminobutyric acid for application in a method for the treatment of the human or animal body.

Abstract: The invention relates to a composition containing as active agent ectoine, hydroxyectoine and/or salts, esters or amides of these compounds for use in a method for the treatment and/or prophylaxis of gastroesophageal reflux diseases, inflammation of and damage to the gastric or duodenal mucosa and/or of gastric or duodenal ulcers.

Abstract: The invention relates to a composition containing as active agent ectoine, hydroxyectoine and/or salts, esters or amides of these compounds for the stimulation of sirtuin activity, in particular for the treatment of diseases that are associated with reduced activity of sirtuins. These include in particular various aging phenomena and diseases that occur primarily in old age or are associated with an impaired cell differentiation or cell proliferation.

Abstract: The invention relates to a compatible solute or a solute mixture as well as to a composition comprising at least one solute or one solute mixture for use in the prevention or treatment of barrier malfunctions of epithelial tissues associated with at least one biobased noxa, in particular of diseases comprising at least one barrier malfunction in at least one cell layer of at least one epithelial tissue, wherein at least one solute is selected from compounds of formula I, of formula II, physiologically compatible salts of formula I, formula II, stereoisomeric forms of the compounds of formula I, formula II, and physiologically compatible salts of the stereoisomeric forms, or a mixture of at least two of the afore-mentioned compounds. The at least one compatible solute, solute mixture and/or the compositions are provided in the form of a cosmetic, medical product, medicament, of an additive to one of the afore-mentioned products or as component of an in-vitro diagnostic product (IVD).

Abstract: The invention relates to a compatible solute or a solute mixture, as well as to a composition comprising the solute or solute mixture, for use in the prevention or treatment of cosmetic or pathologic efflorescences caused by airborne particles, such as pigmentation accompanying with skin ageing, and de- or hypopigmentation, hyperpigmentation, as well as alterations accompanying with atrophy in the broadest sense.

Abstract: The invention relates to a composition containing as active agent ectoine, hydroxyectoine, glucosylglycerol and/or salts, esters or amides of these compounds for promoting the regeneration of injured body tissue. The invention has special significance for the treatment of chronic wounds or ulcers.

Abstract: The invention relates to a composition containing, as active ingredient, ectoine, hydroxyectoine and/or salts, esters or amides of these compounds for the treatment and/or prophylaxis of diseases of the eye that are associated with a disturbance of the tear film. The disease can be in particular a keratoconjunctivitis sicca. It has been found that, surprisingly, these compounds are capable of preventing a rupture in the outer lipid layer of the tear film, avoiding an undesirably rapid evaporation of the lacrimal fluid.

Abstract: A method of treatment of a patient suffering from postoperative inflammatory stress and pain caused by mechanical impact exerted on portions of the body of the patient that causes damaged tissue wherein the inflammatory stress and pain of the operation outlast the healing of damaged tissue and which is not related to, or caused by, uncontrolled proteolysis. The treatment comprises administering a tetrahydropyrimidine selected from ectoine and/or hydroxyectoine to the patient.

Abstract: The invention relates to a composition containing as active agent ectoine, hydroxyectoine, glucosylglycerol and/or salts, esters or amides of these compounds for promoting the regeneration of injured body tissue. The invention has special significance for the treatment of chronic wounds or ulcers.

Abstract: The invention relates to a storage solution for the preservation of organs, tissue or organ systems to be transplanted, said solution being based on the known HTK, UW or Celsior solutions. In accordance with the invention it has been determined that ischemia and reperfusion injury could be reduced through the addition of ectoine or hydroxyectoine.

Abstract: The invention relates to a composition containing ectoine, hydroxyectoine and/or a salt, ester or amide of these compounds for the suppression of anti-apoptotic signals to neutrophil granulocytes and other cells taking part in inflammations. The delayed apoptosis of the neutrophils is a main component for various types of inflammation. Through the administration of ectoine restoring the normal rate of apoptosis is accomplished at least partially which is associated with a corresponding improvement of the inflammatory phenomena.

Abstract: Tetrahydropyrimidines of the formula where R is a hydrogen atom or a hydrocarbon radical comprising up to eight carbon atoms, R? is hydrogen, OH or OR? and R? is R or COR, with R having the above described significance for use in the prevention or treatment of post-operative inflammatory stresses and pain.