Abstract: The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.

Abstract: The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.

Abstract: An internal combustion engine is provided, including at least one crankcase, at least one oil pump, at least one oil filter, at least one oil circuit, at least one control valve, and at least one device for separating particulate contaminants from a fluid flow, in particular for separating contaminants from the crankcase of the internal combustion engine, this fluid or oil flow to be purified having at least one containment for receiving the contaminants.

Abstract: Described is an internal combustion engine, in particular including a dual-circuit water cooling system, including a crankcase and at least one inlet and/or outlet rail which is/are situated upstream from the crankcase and receives a coolant communicating with this crankcase, at least one coolant-conducting cylinder head, and at least one outlet and/or inlet rail downstream from the cylinder head receiving a coolant communicating with the cylinder head.