Abstract: The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample.

Abstract: The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample.

Abstract: The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample.

Abstract: Cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample. The cartridge includes one or more nucleic acid sequences, wherein the cartridge has a generic part and one or more separate application-specific parts, which are connectable to the generic part.

Abstract: The present invention provides a universally applicable lysis buffer comprising a chaotropic 5 agent, a reducing agent, and a proteolytic enzyme suitable for processing a wide variety of different sample types, such as different types of bodily samples relevant for the diagnosis of a respiratory disease. Furthermore, the present invention provides the use of a chaotropic agent, a reducing agent, and a proteolytic enzyme for the lysis of a broad spectrum of bodily samples. Moreover, the present invention provides a method for processing bodily samples which is universally applicable to the lysis of a variety of different types of bodily samples. Furthermore, the present invention provides methods for analyzing a bodily sample or for detecting the presence of a pathogen in a bodily sample, preferably, for diagnosing a respiratory disease, such as pneumonia or tuberculosis.

Abstract: The present invention provides a reaction vessel (20) for a PCR device. The reaction vessel (20) comprises a sample vial (32) defining a reaction chamber (33) for performing PCR and a storage vessel (62) defining a storage chamber (63) for optical detection. The reaction chamber (33) is in fluid communication with a liquid supply port (34) for supplying a liquid sample containing at least one target DNA to the reaction chamber (33). The reaction chamber (33) and the storage chamber (63) are in fluid communication via a spacer element (42) and a porous membrane (51) for hybridization of the at least one target DNA within the liquid sample onto specific immobilised hybridization probes. The lower end of the spacer element (42) extends into the reaction chamber (33), but does not reach the bottom thereof. The upper end of the spacer element (42) is located in proximity of the porous membrane (51), which is made from a material having different physical properties in a dry state and a wet state.

Abstract: Cartridge and method for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a one or more nucleic acid sequences, and the cartridge includes a generic part and one or more separate application-specific parts, which are connectable to the generic part.

Abstract: The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample.

Abstract: The present invention provides a reaction vessel (20) for a PCR device. The reaction vessel (20) comprises a sample vial (32) defining a reaction chamber (33) for performing PCR and a storage vessel (62) defining a storage chamber (63) for optical detection. The reaction chamber (33) is in fluid communication with a liquid supply port (34) for supplying a liquid sample containing at least one target DNA to the reaction chamber (33). The reaction chamber (33) and the storage chamber (63) are in fluid communication via a spacer element (42) and a porous membrane (51) for hybridization of the at least one target DNA within the liquid sample onto specific immobilised hybridization probes. The lower end of the spacer element (42) extends into the reaction chamber (33), but does not reach the bottom thereof. The upper end of the spacer element (42) is located in proximity of the porous membrane (51), which is made from a material having different physical properties in a dry state and a wet state.

Abstract: The present invention provides a universally applicable lysis buffer comprising a chaotropic 5 agent, a reducing agent, and a proteolytic enzyme suitable for processing a wide variety o different sample types, such as different types of bodily samples relevant for the diagnosis o a respiratory disease. Furthermore, the present invention provides the use of a chaotropic agent, a reducing agent, and a proteolytic enzyme for the lysis of a broad spectrum of bodily samples. Moreover, the present invention provides a method for processing bodily samples which is universally applicable to the lysis of a variety of different types of bodily samples. Furthermore, the present invention provides methods for analyzing a bodily sample or for detecting the presence of a pathogen in a bodily sample, preferably, for diagnosing a respiratory disease, such as pneumonia or tuberculosis.

Abstract: Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed is a system for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. This system comprising a reusable apparatus, wherein said apparatus is configured to receive a cartridge and to control a process for the detection of the presence, absence and/or amount of a target nucleotide sequence in the sample, being present in said cartridge.

Abstract: A patient presses a finger concurrently against a needle (14) of a collection container (12) and a fingerprint surface (22, 52). In one embodiment, the patient's fingerprint is read electronically by a scanner (24) and correlated with a container serial number (16). In another embodiment, the patient's fingerprint is embossed in a foil layer (52). An analyzer assembly (40, 40? 40?) analyzes the biological sample and reads either the container serial number or scans the fingerprint carrying layer (52) and sends the test results and either the fingerprint or container identification to a patient memory (30). Using the fingerprint information, a processor (32) correlates the test results with a record (60) of a corresponding patient. Alternately or additionally, the analyzer assembly includes a DNA analyzer (70) which measures preselected DNA characteristics (76) of the sample.

Abstract: A biochip has an integrated temperature sensor comprising a micro mechanical actuator (20) having a deformation dependent on temperature, and a detector (30) arranged to output a signal according to a deformation of the actuator. The actuator can be formed of LC material in an elastomeric network. The detector (30) can be optical, magnetic or capacitive. The actuator can be arranged as a layer and the deformation be a curling of the layer.

Abstract: Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the step of introducing said sample fluid into a chamber equipped with a porous substrate, one or more probe molecules being applied to said porous substrate and said probes being able to specifically bind to said one or more target molecules. The method further comprises the step of moving said substrate and said chamber relatively to each other in order to force said sample fluid through the pores of said porous substrate and to capture the one or more target molecules with the one or more probe molecules. Also disclosed is a sensor for the analysis of a sample fluid.

Abstract: Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the steps of applying a non-activated porous organic polymer membrane with probes in the form of an array of probe locations, said probes being able to specifically bind to said one or more target molecules. Furthermore, the method comprises the steps of blocking areas remaining free of probes of said porous organic polymer membrane with one or more blocking substances and forcing the sample fluid repeatedly in one or two directions through the pores of said porous organic polymer membrane. Also disclosed is a sensor for the analysis of a sample fluid.

Abstract: Disclosed is a method for performing a microarray assay on one or more sample fluid(s), said fluids comprising target biological compounds. The method comprises the step of tagging said target biological compounds with labels. The following step comprises contacting said sample fluid(s) with a substrate and detecting the presence of said labels at the surface of said substrate. The method is suitable for the simultaneous analysis, in one microarray, of one or more types of target biological compounds, in one or more sample fluid(s). To this end each of said types of biological compounds is tagged with a different label so that target biological compounds belonging to different sample fluids have different labels. Said different labels are discriminable upon detection at the surface of said substrate. Also disclosed is the use of a polymer substrate in a method for performing a microarray assay.

Abstract: Disclosed is a telemetry system (10) with a receiver unit (50) and a plurality of transmitters (20–40), each adapted for providing a wireless communicating with the receiver unit (50). The receiver unit (50) comprises a plurality of transmitter holding positions (52–56), such as insertion slots, for receiving one of the transmitters (20–40), and means for assigning one of the transmitter holding positions (52–56) to the transmitter (20–40) received in the assigned transmitter holding position (52–56).

Abstract: The present invention relates to a system for point of care diagnosis and/or analysis of body fluids of a patient, comprising:—a cartridge (2),—a diagnosis and/or analysis apparatus (3),—means (6) for measurement of the concentration of at least one specific component of a sample of the body fluids,—connecting means (8, 13) providing communication for electrical and/or Ooptical values between the cartridge (2) and the diagnosis and/or analysis apparatus (3),—wherein said values correlate with at least one of the respective concentrations,—diagnosing and/or analyzing means (14) measuring the respective concentration value via the connecting means (8, 13),—storage means (10) for storing cartridge specific data and/or information,—reading means (15) for reading the data and/or information out of the storage means (10),—wherein the diagnosing and/or analyzing means (14) evaluate the respective concentration values in accordance to the cartridge specific data a

Abstract: Disclosed is a system for measuring a physiological parameter of a patient. A measuring means (12) measures a signal representative for the physiological parameter of the patient, and an operator identification means (10) provides an operator identification signal for identifying an operator performing or helping to perform the measurement. The measured signal is associated with the operator identification signal for identifying the measured signal and thus providing an operator identified measuring signal (14).