Patents by Inventor Andreas Brand

Andreas Brand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6168294
    Abstract: A signal light including a housing is recessed into a traffic surface and projects minimally upwardly from the surface and wherein a light processing assembly is provided to receive light from a light source, intensify the light and direct the light toward a light outlet in a generally linear manner, the arrangement for processing light being mounted to the housing. For this purpose, the light source is designed in such a way that it sends an essentially linearly directed light beam onto the light processing assembly. The light is collected in the light processing assembly in such a way that, when it exits, it is still linearly extending in at least one direction but it has a higher intensity. For this purpose, the light processing assembly includes a cylindrical-convex lens entry surface and a cylindrical concave mirror surface for receiving and directing light.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: January 2, 2001
    Assignee: Ernst Erni
    Inventors: Ernst R. Erni, Andreas Brand
  • Patent number: 6071730
    Abstract: The design of new ribozymes capable of self-catalyzed trans-splicing which are based upon the catalytic core of a Group I intron are described. Using this design, it is possible to construct ribozymes capable of efficiently splicing a new 3' exon sequence into any chosen target RNA sequence in a highly precise manner. A method of cell ablation is also described that provides a toxic product to a host cell in vivo in a targetted, regulated manner utilizing novel trans-splicing ribozymes of the invention. Inactive pro-ribozyme forms are also described.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 6, 2000
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: James Haseloff, Andrea Brand, Norbert Perrimon, Howard M. Goodman
  • Patent number: 6010904
    Abstract: The design of new ribozymes capable of self-catalyzed trans-splicing which are based upon the catalytic core of a Group I intron are described. Using this design, it is possible to construct ribozymes capable of efficiently splicing a new 3' exon sequence into any chosen target RNA sequence in a highly precise manner. A method of cell ablation is also described that provides a toxic product to a host cell in vivo in a targetted, regulated manner utilizing novel trans-splicing ribozymes of the invention. Inactive pro-ribozyme forms are also described.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 4, 2000
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: James Haseloff, Andrea Brand, Norbert Perrimon, Howard M. Goodman
  • Patent number: 5882907
    Abstract: The design of new ribozymes capable of self-catalyzed trans-splicing which are based upon the catalytic core of a Group I intron are described. Using this design, it is possible to construct ribozymes capable of efficiently splicing a new 3' exon sequence into any chosen target RNA sequence in a highly precise manner. A method of cell ablation is also described that provides a toxic product to a host cell in vivo in a targetted, regulated manner utilizing novel trans-splicing ribozymes of the invention. Inactive pro-ribozyme forms are also described.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 16, 1999
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: James Haseloff, Andrea Brand, Norbert Perrimon, Howard M. Goodman
  • Patent number: 5866384
    Abstract: The design of new ribozymes capable of self-catalyzed trans-splicing which are based upon the catalytic core of a Group I intron are described. Using this design, it is possible to construct ribozymes capable of efficiently splicing a new 3' exon sequence into any chosen target RNA sequence in a highly precise manner. A method of cell ablation is also described that provides a toxic product to a host cell in vivo in a targetted, regulated manner utilizing novel trans-splicing ribozymes of the invention. Inactive pro-ribozyme forms are also described.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 2, 1999
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: James Haseloff, Andrea Brand, Norbert Perrimon, Howard M. Goodman
  • Patent number: 5863774
    Abstract: The design of new ribozymes capable of self-catalyzed trans-splicing which are based upon the catalytic core of a Group I intron are described. Using this design, it is possible to construct ribozymes capable of efficiently splicing a new 3' exon sequence into any chosen target RNA sequence in a highly precise manner. A method of cell ablation is also described that provides a toxic product to a host cell in vivo in a targetted, regulated manner utilizing novel trans-splicing ribozymes of the invention. Inactive pro-ribozyme forms are also described.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 26, 1999
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: James Haseloff, Andrea Brand, Norbert Perrimon, Howard M. Goodman
  • Patent number: 5849548
    Abstract: The design of new ribozymes capable of self-catalyzed trans-splicing which are based upon the catalytic core of a Group I intron are described. Using this design, it is possible to construct ribozymes capable of efficiently splicing a new 3' exon sequence into any chosen target RNA sequence in a highly precise manner. A method of cell ablation is also described that provides a toxic product to a host cell in vivo in a targetted, regulated manner utilizing novel trans-splicing ribozymes of the invention. Inactive pro-ribozyme forms are also described.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 15, 1998
    Assignees: The General Hospital Corporation, The President and Fellows of Harvard College
    Inventors: James Haseloff, Andrea Brand, Norbert Perrimon, Howard M. Goodman
  • Patent number: 5641673
    Abstract: The design of new ribozymes capable of self-catalyzed trans-splicing which are base a upon the catalytic core of a Group I intron are described. Using this design, it is possible to construct ribozymes capable of efficiently splicing a new 3' exon sequence into any chosen target RNA sequence in a highly precise manner. A method of cell ablation is also described that provides a toxic product to a host cell in vivo in a targetted, regulated manner utilizing novel trans-splicing ribozymes of the invention. Inactive pro-ribozyme forms are also described.
    Type: Grant
    Filed: December 23, 1993
    Date of Patent: June 24, 1997
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: James Haseloff, Andrea Brand, Norbert Perrimon, Howard M. Goodman
  • Patent number: 4732004
    Abstract: In a process for purifying and deaerating the feed water line in the circulation system of a power-generating plant heated by nuclear power, the following steps are carried out in order to solve acute problems of steam-generator corrosion:(a) when the preheater train is filled, with the steam-generator isolating valve (40) closed, the condensate flows several times via a recirculation line (37, 52, 53) back to the condensate-collecting vessel (6) and to the condensate purification apparatus (9);(b) below the water level (7) in the condensate-collecting vessel (6), a deaerating medium (37,38,39) is introduced into the condensate via spray nozzles, rises in the condensate and forms in the deaerating chamber (44), as result of displacement of the air present in its, a cushion which is conducive to oxygen deaerating;(c) the steam produced during deaerating is precipitated in an additional condenser (48) which is located in the venting line upstream of the vacuum pump (47) and which is subjected to a secondary coo
    Type: Grant
    Filed: July 17, 1984
    Date of Patent: March 22, 1988
    Assignee: BBC Brown, Boveri & Company Limited
    Inventors: Andreas Brand, Helmut Lang
  • Patent number: 4404929
    Abstract: In order to improve upon the prior arrangement of a valve within a liquid distributor head for a mixing pre-heater degasifier it is proposed that a valve containing a valve plate, valve shaft, valve spring and spring plate, is arranged within the mixing pre-heater centrally within a deflection screen or baffle and at the same time the valve is surrounded by a protective housing in order to prevent that, in the event of possible rupture of the valve spring any broken pieces thereof will drop into the mixing pre-heater.
    Type: Grant
    Filed: June 1, 1982
    Date of Patent: September 20, 1983
    Assignee: BBC Brown Boveri & Company Limited
    Inventors: Andreas Brand, Rudolf Datz