Patents by Inventor Andreas Buckmann

Andreas Buckmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4443594
    Abstract: A process for the production of adenine ring system containing co-enzymes bound to a macro-molecular carrier comprising the steps of alkylating an adenine ring system containing co-enzyme in the 1 position with an alkylating agent containing a terminal group capable of reacting with said macro-molecular carrier selected from the group consisting of carboxyl, amine and vinyl, reacting said alkylated co-enzyme with a macro-molecular carrier having groups capable of reacting with said terminal groups, subjecting said alkylated co-enzyme bound to a macro-molecular carrier to a Dimroth rearrangement into the N.sup.6 -form of alkylation, and recovering said adenine ring system containing co-enzyme bound to a macro-molecular carrier.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: April 17, 1984
    Assignee: Gesellschaft fur biotechnologische forschung mbH (GBF)
    Inventor: Andreas Buckmann
  • Patent number: 4326031
    Abstract: Water soluble .alpha.-ketocarboxylic acids are continuously converted in a membrane reactor into the corresponding .alpha.-hydrocarboxylic acids. The conversion takes place in the presence of a substrate specific dehydrogenase and of a nicotinamide-adenine-dinucleotide (NAD.sup.+ /NADH) enlarged in molecular weight through linkage to a water soluble polymer as coenzyme. Simultaneously NADH is regenerated continuously from NAD.sup.+ in presence of a formate dehydrogenase and from formate ion. The membrane must have a mean pore diameter of 1 to 3 nm. As coenzyme there is employed 0.1 to 10 mmol/l of NAD.sup.+ /NADH present bound to a water soluble polymer having an average molecular weight between 500 and 50,000. There is continuously supplied to the reactor a substrate stream which contains 50 to 100% of the maximum amount soluble, but not over 2,000 mmol/l, of the reacting .alpha.-ketocarboxylic acid in the form of a water soluble salt and 100 to 6,000 mmol/l of a formate.
    Type: Grant
    Filed: July 25, 1980
    Date of Patent: April 20, 1982
    Assignee: Degussa AG
    Inventors: Christian Wandrey, Rolf Wichmann, Wolfgang Leuchtenberger, Maria-Regina Kula, Andreas Buckmann
  • Patent number: 4304858
    Abstract: Water soluble .alpha.-ketocarboxylic acids are continuously converted in a membrane reactor into the corresponding aminoacids. The conversion takes place in the presence of a substrate specific dehydrogenase, of ammonium ions and of a nicotinamide-adenine-dinucleotide (NAD.sup.+ /NADH) enlarged in molecular weight through linkage to a water soluble polymer as coenzyme. Simultaneously NADH is regenerated continuously from NAD.sup.+ in presence of a formate dehydrogenase and from formate ion. The membrane must have a mean pore diameter of 1 to 3 nm. As coenzyme there is employed 0.1 to 10 mmol/l of NAD.sup.+ /NADH present bound to a polyoxyethylene having an average molecular weight between 500 and 50,000. There is continuously supplied to the reactor a substrate stream which contains 50 to 100% of the maximum amount soluble, but not over 2,000 mmol/l, of the reacting .alpha.
    Type: Grant
    Filed: July 25, 1980
    Date of Patent: December 8, 1981
    Assignee: Degussa Aktiengesellschaft
    Inventors: Christian Wandrey, Rolf Wichmann, Wolfgang Leuchtenberger, Maria-Regina Kula, Andreas Buckmann