Patents by Inventor Andreas Claas
Andreas Claas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10626441Abstract: Described herein is a method for adding a counter sequence to the individual polynucleotide molecules of an initial nucleic acid sample. After addition of the counter sequence, the sample may be amplified and the number of initial target molecules in the sample can be estimated by counting the number of counter sequences associated with the amplified target molecules.Type: GrantFiled: April 27, 2017Date of Patent: April 21, 2020Assignee: Agilent Technologies, Inc.Inventors: Robert Osborne, James Casbon, Andreas Claas, Gi Mikawa, Esther Musgrave-Brown
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Publication number: 20170226562Abstract: Described herein is a method for adding a counter sequence to the individual polynucleotide molecules of an initial nucleic acid sample. After addition of the counter sequence, the sample may be amplified and the number of initial target molecules in the sample can be estimated by counting the number of counter sequences associated with the amplified target molecules.Type: ApplicationFiled: April 27, 2017Publication date: August 10, 2017Inventors: Robert Osborne, James Casbon, Andreas Claas, Gi Mikawa, Esther Musgrave-Brown
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Patent number: 9670536Abstract: Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications.Type: GrantFiled: May 8, 2014Date of Patent: June 6, 2017Assignee: POPULATION GENETICS TECHNOLOGIES LTD.Inventors: James Casbon, Sydney Brenner, Robert Osborne, Conrad Lichtenstein, Andreas Claas
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Patent number: 9670529Abstract: Described herein is a method for adding a counter sequence to the individual polynucleotide molecules of an initial nucleic acid sample. After addition of the counter sequence, the sample may be amplified and the number of initial target molecules in the sample can be estimated by counting the number of counter sequences associated with the amplified target molecules.Type: GrantFiled: February 26, 2013Date of Patent: June 6, 2017Assignee: POPULATION GENETICS TECHNOLOGIES LTD.Inventors: Robert Osborne, James Casbon, Andreas Claas, Gi Mikawa, Esther Musgrave-Brown
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Patent number: 9567083Abstract: The invention relates to a modular on-board galley, in particular an aircraft galley (11), and a method of assembling such a galley that comprises, as utility zones, a base and at least one attachment element divided into compartments for accommodating drawers and devices, the compartments being designed with mechanical connectors for interconnecting the elements and with inserts or devices as well as electrical and electronic device connectors and device supply lines. Such a modular on-board galley that not only offers a variable structure but also enables the galley to be completely assembled in a simple manner with preassembled space-saving block- and housing-like attachments and superstructures that are nevertheless compact with regard to their dimensions, in particular in an aircraft that is fully equipped with seats, cabinets and on-board toilets, without these installed components having to be removed beforehand, is to be created.Type: GrantFiled: January 25, 2012Date of Patent: February 14, 2017Assignee: SELL GMBHInventors: Steffen Saeltzer, Andreas Claas
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Publication number: 20150197786Abstract: Described herein is a method for adding a counter sequence to the individual polynucleotide molecules of an initial nucleic acid sample. After addition of the counter sequence, the sample may be amplified and the number of initial target molecules in the sample can be estimated by counting the number of counter sequences associated with the amplified target molecules.Type: ApplicationFiled: February 26, 2013Publication date: July 16, 2015Applicant: Population Genetics Technologies Ltd.Inventors: Robert Osborne, James Casbon, Andreas Claas, Gi Mikawa, Esther Musgrave-Brown
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Publication number: 20150031559Abstract: Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications.Type: ApplicationFiled: May 8, 2014Publication date: January 29, 2015Applicant: Population Genetics Technologies LtdInventors: James Casbon, Sydney Brenner, Robert Osborne, Conrad Lichtenstein, Andreas Claas
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Patent number: 8741606Abstract: Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications.Type: GrantFiled: March 29, 2013Date of Patent: June 3, 2014Assignee: Population Genetics Technologies Ltd.Inventors: James Casbon, Sydney Brenner, Robert Osborne, Conrad Lichtenstein, Andreas Claas
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Patent number: 8728766Abstract: Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications.Type: GrantFiled: March 29, 2013Date of Patent: May 20, 2014Assignee: Population Genetics Technologies Ltd.Inventors: James Casbon, Sydney Brenner, Robert Osborne, Conrad Lichtenstein, Andreas Claas
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Patent number: 8722368Abstract: Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications.Type: GrantFiled: March 29, 2013Date of Patent: May 13, 2014Assignee: Population Genetics Technologies Ltd.Inventors: James Casbon, Sydney Brenner, Robert Osborne, Conrad Lichtenstein, Andreas Claas
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Patent number: 8715967Abstract: Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications.Type: GrantFiled: March 29, 2013Date of Patent: May 6, 2014Assignee: Population Genetics Technologies Ltd.Inventors: James Casbon, Sydney Brenner, Robert Osborne, Conrad Lichtenstein, Andreas Claas
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Patent number: 8685678Abstract: Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications.Type: GrantFiled: March 28, 2013Date of Patent: April 1, 2014Assignee: Population Genetics Technologies LtdInventors: James Casbon, Sydney Brenner, Robert Osborne, Conrad Lichtenstein, Andreas Claas
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Publication number: 20140034782Abstract: The invention relates to a modular on-board galley, in particular an aircraft galley (11), and a method of assembling such a galley that comprises, as utility zones, a base and at least one attachment element divided into compartments for accommodating drawers and devices, the compartments being designed with mechanical connectors for interconnecting the elements and with inserts or devices as well as electrical and electronic device connectors and device supply lines. Such a modular on-board galley that not only offers a variable structure but also enables the galley to be completely assembled in a simple manner with preassembled space-saving block- and housing-like attachments and superstructures that are nevertheless compact with regard to their dimensions, in particular in an aircraft that is fully equipped with seats, cabinets and on-board toilets, without these installed components having to be removed beforehand, is to be created.Type: ApplicationFiled: January 25, 2012Publication date: February 6, 2014Inventors: Steffen Saeltzer, Andreas Claas
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Publication number: 20130267424Abstract: Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications.Type: ApplicationFiled: March 29, 2013Publication date: October 10, 2013Inventors: James Casbon, Sydney Brenner, Robert Osborne, Conrad Lichtenstein, Andreas Claas
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Publication number: 20130237458Abstract: Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications.Type: ApplicationFiled: March 29, 2013Publication date: September 12, 2013Applicant: Population Genetics Technologies LtdInventors: James Casbon, Sydney Brenner, Robert Osborne, Conrad Lichtenstein, Andreas Claas
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Patent number: 8481292Abstract: Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications.Type: GrantFiled: September 20, 2011Date of Patent: July 9, 2013Assignee: Population Genetics Technologies Litd.Inventors: James Casbon, Sydney Brenner, Robert Osborne, Conrad Lichtenstein, Andreas Claas