Patents by Inventor Andreas Cornelius

Andreas Cornelius has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Packaging of Immunostimulatory Substances Into Virus-Like Particles: Method of Preparation and Use
    Publication number: 20100098722
    Abstract: The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
    Type: Application
    Filed: March 24, 2009
    Publication date: April 22, 2010
    Inventors: Martin F. BACHMANN, Andreas Cornelius, Vania Manolova, Patrik Maurer, Edwin Meijerink, Karl G. Proba, Katrin Schwarz
  • Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use
    Patent number: 7517520
    Abstract: The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
    Type: Grant
    Filed: March 25, 2004
    Date of Patent: April 14, 2009
    Assignee: Cytos Biotechnology AG
    Inventors: Vania Manolova, Martin F. Bachmann, Andreas Cornelius, Patrik Maurer, Edwin Meijerink, Karl G. Proba, Katrin Schwarz
  • Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use
    Publication number: 20060251677
    Abstract: The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
    Type: Application
    Filed: March 25, 2004
    Publication date: November 9, 2006
    Inventors: Martin Bachmann, Andreas Cornelius, Vania Manolova, Patrik Maurer, Edwin Meijerink, Karl Proba, Katrin Schwarz