Patents by Inventor Andreas Crameri

Andreas Crameri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Unstructured recombinant polymers and uses thereof
    Patent number: 7855279
    Abstract: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: December 21, 2010
    Assignee: Amunix Operating, Inc.
    Inventors: Volker Schellenberger, Willem P. Stemmer, Chia-wei Wang, Michael D. Scholle, Mikhail Popkov, Nathaniel C. Gordon, Andreas Crameri
  • Methods for production of unstructured recombinant polymers and uses thereof
    Patent number: 7846445
    Abstract: The present invention provides methods of using unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities, and the uses thereof. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: December 7, 2010
    Assignee: Amunix Operating, Inc.
    Inventors: Volker Schellenberger, Willem P. Stemmer, Chia-wei Wang, Michael D. Scholle, Mikhail Popkov, Nathaniel C. Gordon, Andreas Crameri
  • METHODS FOR GENERATING POLYNUCLEOTIDES HAVING DESIRED CHARACTERISTICS BY ITERATIVE SELECTION AND RECOMBINATION
    Publication number: 20100286369
    Abstract: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
    Type: Application
    Filed: February 1, 2008
    Publication date: November 11, 2010
    Applicant: Maxygen, Inc.
    Inventors: Willem P.C. Stemmer, Andreas Crameri
  • Methods for Generating Polynucleotides Having Desired Characteristics by Iterative Selection and Recombination
    Publication number: 20100222237
    Abstract: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
    Type: Application
    Filed: September 11, 2009
    Publication date: September 2, 2010
    Applicant: Maxygen, Inc.
    Inventors: Willem P.C. Stemmer, Andreas Crameri
  • Biologically active proteins having increased In Vivo and/or In Vitro stability
    Publication number: 20100189682
    Abstract: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
    Type: Application
    Filed: December 9, 2009
    Publication date: July 29, 2010
    Inventors: Volker Schellenberger, Willem P. Stemmer, Chia-wei Wang, Michael D. Scholle, Mikhail Popkov, Nathaniel C. Gordon, Andreas Crameri
  • OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION
    Publication number: 20100184627
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Application
    Filed: September 11, 2009
    Publication date: July 22, 2010
    Applicant: Maxygen, Inc.
    Inventors: Andreas Crameri, Willem P.C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, John E. Ness, Claes Gustafsson, Phillip A. Patten
  • Genetic package and uses thereof
    Publication number: 20090099031
    Abstract: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
    Type: Application
    Filed: March 6, 2007
    Publication date: April 16, 2009
    Inventors: Willem P. Stemmer, Volker Schellenberger, Chia-wei Wang, Michael D. Scholle, Mikhail Popkov, Nathaniel C. Gordon, Andreas Crameri
  • Integrated system for diversity generation and screening
    Patent number: 7462469
    Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: December 9, 2008
    Assignee: Maxygen, Inc.
    Inventors: Steven H. Bass, S. Christopher Davis, Phillip A. Patten, Matthew Tobin, Jeremy Minshull, Mark Welch, Claes Gustafsson, Brian Carr, Stephane Jenne, Sun Ai Raillard, Andreas Crameri, Willem P. C. Stemmer, Robin Emig, Pascal Longchamp, Stanley Goldman, Lorraine J. Giver, Joseph A. Affholter
  • Methods for production of unstructured recombinant polymers and uses thereof
    Publication number: 20080286808
    Abstract: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
    Type: Application
    Filed: March 6, 2007
    Publication date: November 20, 2008
    Inventors: Volker Schellenberger, Willem P. Stemmer, Chia-wei Wang, Michael D. Scholle, Mikhail Popkov, Nathaniel C. Gordon, Andreas Crameri
  • METHODS FOR GENERATING POLYNUCLEOTIDES HAVING DESIRED CHARACTERISTICS BY ITERATIVE SELECTION AND RECOMBINATION
    Publication number: 20080261833
    Abstract: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
    Type: Application
    Filed: August 22, 2007
    Publication date: October 23, 2008
    Applicant: MAXYGEN, INC.
    Inventors: WILLEM P.C. STEMMER, Andreas Crameri
  • Oligonucleotide mediated nucleic acid recombination
    Publication number: 20080171668
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Application
    Filed: November 30, 2007
    Publication date: July 17, 2008
    Applicant: Maxygen, Inc.
    Inventors: Andreas Crameri, Willem P.C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, Jon E. Ness, Claes Gustafsson, Phillip A. Patten
  • Unstructured recombinant polymers and uses thereof
    Publication number: 20080039341
    Abstract: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
    Type: Application
    Filed: March 6, 2007
    Publication date: February 14, 2008
    Inventors: Volker Schellenberger, Willem Stemmer, Chia-wei Wang, Michael Scholle, Mikhail Popkov, Nathaniel Gordon, Andreas Crameri
  • Integrated Systems and Methods for Diversity Generation and Screening
    Publication number: 20080015116
    Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
    Type: Application
    Filed: February 21, 2007
    Publication date: January 17, 2008
    Applicant: MAXYGEN, INC.
    Inventors: Steven Bass, S. Davis, Phillip Patten, Matthew Tobin, Jeremy Minshull, Mark Welch, Claus Gustafsson, Brian Carr, Stephane Jenne, Sun Raillard, Andreas Crameri, Willem Stemmer, Robin Emig, Pascal Longschamp, Stanley Goldman, Lorraine Giver, Joseph Affholter
  • Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
    Patent number: 7288375
    Abstract: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: October 30, 2007
    Assignee: Maxygen, Inc.
    Inventors: Willem P. C. Stemmer, Andreas Crameri
  • Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
    Publication number: 20070092887
    Abstract: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
    Type: Application
    Filed: April 14, 2006
    Publication date: April 26, 2007
    Applicant: Maxygen, Inc.
    Inventors: Willem Stemmer, Andreas Crameri
  • OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION
    Publication number: 20070065838
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Application
    Filed: March 23, 2006
    Publication date: March 22, 2007
    Applicant: Maxygen, Inc.
    Inventors: Andreas Crameri, Willem Stemmer, Jeremy Minshull, Steven Bass, Mark Welch, John Ness, Claes Gustafsson, Phillip Patten
  • Oligonucleotide mediated nucleic acid recombination
    Publication number: 20070054313
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Application
    Filed: November 13, 2006
    Publication date: March 8, 2007
    Applicant: Maxygen, Inc.
    Inventors: Andreas Crameri, Willem Stemmer, Jeremy Minshull, Steven Bass, Mark Welch, Jon Ness, Claes Gustafsson, Phillip Patten
  • Oligonucleotide mediated nucleic acid recombination
    Publication number: 20060051795
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Application
    Filed: August 15, 2005
    Publication date: March 9, 2006
    Applicant: Maxygen, Inc.
    Inventors: Andreas Crameri, Willem Stemmer, Jeremy Minshull, Steven Bass, Mark Welch, Jon Ness, Claes Gustafsson, Phillip Patten
  • Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
    Publication number: 20050186622
    Abstract: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
    Type: Application
    Filed: March 28, 2005
    Publication date: August 25, 2005
    Applicant: Maxygen, Inc.
    Inventors: Willem Stemmer, Andreas Crameri
  • Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
    Patent number: 6602986
    Abstract: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: August 5, 2003
    Assignee: Maxygen, Inc.
    Inventors: Willem P. C. Stemmer, Andreas Crameri