Abstract: The invention relates to the surprising finding that biomarkers corresponding to ACAA1, AP1M2, CGN, DDR1, EPS8L2, FASTKD1, GMIP, IKBKE, P2RX4, P4HB, PHKG2, PPFIBP2, PPP1R16A, RASSF7, RNF183, SIRT6, TJP3, EFEMP2, SOCS2, and DCN are differentially expressed in control samples as compared to samples from patients having endometrial cancer and are therefore useful for detecting endometrial cancer. In particular these biomarkers having excellent sensitivity, specificity, and/or the ability to separate affected from non affected individuals. Furthermore, the inventors found that the differential expression of these biomarkers in primary endometrial cancer tumor tissue is correlated to their expression level in uterine fluid samples as compared to control values. Thus these biomarkers are robust in that they are found to be differentially expressed in several different types of samples from affected and individuals.

Abstract: The invention relates to the surprising finding that biomarkers corresponding to ACAA1, AP1M2, CGN, DDR1, EPS8L2, FASTKD1, GMIP, IKBKE, P2RX4, P4HB, PHKG2, PPFIBP2, PPP1 R16A, RASSF7, RNF183, SIRT6, TJP3, EFEMP2, S0CS2, and DCN are differentially expressed in control samples as compared to samples from patients having endometrial cancer and are therefore useful for detecting endometrial cancer. In particular these biomarkers having excellent sensitivity, specificity, and/or the ability to separate affected from non affected individuals. Furthermore, the inventors found that the differential expression of these biomarkers in primary endometrial cancer tumor tissue is correlated to their expression level in uterine fluid samples as compared to control values. Thus these biomarkers are robust in that they are found to be differentially expressed in several different types of samples from affected individuals.

Abstract: The invention relates to methods and kits for the diagnosis of prostate cancer (PCa) in a subject, for assessing or monitoring the response to a therapy in a subject having PCa or for monitoring the progression of prostate cancer PCa based on the detection of alteration in the expression levels of at least one gene selected from the group of PC A3, PSMA and PSGR. The invention relates as well to methods for assessing whether a subject has to be subjected to a prostate biopsy, said subject having a serum PSA range within 4-10 ng/mL.

Abstract: The present invention relates to the use of PSGR, a member of the G-protein-coupled olfactory receptor family which is over-expressed in prostate cancer tissue, as a marker suitable for an urine-based diagnostic test for prostate cancer which require only typical prostate manipulation and sample acquisition scenarios avoiding invasive tissue collection.

Abstract: The invention relates to a method and a device (01) for dewatering and drying a mixture made of plastic granulate and water, having at least one mixture intake (02), through which the mixture is supplied to the device (01), having at least one water outlet (08), through which the precipitated water is removed from the device (01), having at least one granulate outlet (13), through which the dried granulate is removed from the device (01), the device (01) having a dewatering line (06), along which the mixture is dewatered, and the device (01) having a drying line (12), along which the dewatered granulate is dried.

Abstract: The invention relates to a method for granulating and crystallizing thermoplastic polymers, the granules being contained in a liquid after granulation of a polymer melt and the granules being nucleated in the liquid once the pressure of the liquid is increased and the temperature of the liquid is increased, and the granules being crystallized in the liquid once the pressure of the liquid is again increased and the temperature of the liquid is again increased. According to the invention, the granules are removed from the liquid once the pressure and the temperature of the liquid containing the granules have been reduced.

Abstract: The invention relates to the surprising finding that biomarkers corresponding to ACAA1, AP1M2, CGN, DDR1, EPS8L2, FASTKD1, GMIP, IKBKE, P2RX4, P4HB, PHKG2, PPFIBP2, PPP1 R16A, RASSF7, RNF183, SIRT6, TJP3, EFEMP2, S0CS2, and DCN are differentially expressed in control samples as compared to samples from patients having endometrial cancer and are therefore useful for detecting endometrial cancer. In particular these biomarkers having excellent sensitivity, specificity, and/or the ability to separate affected from non affected individuals. Furthermore, the inventors found that the differential expression of these biomarkers in primary endometrial cancer tumor tissue is correlated to their expression level in uterine fluid samples as compared to control values. Thus these biomarkers are robust in that they are found to be differentially expressed in several different types of samples from affected individuals.

Abstract: The invention relates to a method for the production of granulate grains of polymers from thermoplastic polyesters or copolyesters from a polyester melt using an extrusion granulator. The polyester melt is fed to nozzles of the extrusion granulator and then, with draw-in rollers, to the granulation device via an extraction section as extrusions exiting from the nozzle, wherein, e.g., an extrusion extraction speed is set by the draw-in rollers. The invention also relates to an improved extrusion granulator according to the invention having a wave device between the nozzles and the extraction channel, and granulate grains produced according to the method according to the invention.

Abstract: The invention relates to a method for granulating and crystallizing thermoplastic polymers, the granules being contained in a liquid after granulation of a polymer melt and the granules being nucleated in the liquid once the pressure of the liquid is increased and the temperature of the liquid is increased, and the granules being crystallized in the liquid once the pressure of the liquid is again increased and the temperature of the liquid is again increased. According to the invention, the granules are removed from the liquid once the pressure and the temperature of the liquid containing the granules have been reduced.

Abstract: The invention relates to a method for the production of granulate grains of polymers from thermoplastic polyesters or copolyesters from a polyester melt using an extrusion granulator. The polyester melt is fed to nozzles of the extrusion granulator and then, with draw-in rollers, to the granulation device via an extraction section as extrusions exiting from the nozzle, wherein, e.g., an extrusion extraction speed is set by the draw-in rollers. The invention also relates to an improved extrusion granulator according to the invention having a wave device between the nozzles and the extraction channel, and granulate grains produced according to the method according to the invention.

Abstract: The invention relates to a method and a device (01) for dewatering and drying a mixture made of plastic granulate and water, having at least one mixture intake (02), through which the mixture is supplied to the device (01), having at least one water outlet (08), through which the precipitated water is removed from the device (01), having at least one granulate outlet (13), through which the dried granulate is removed from the device (01), the device (01) having a dewatering line (06), along which the mixture is dewatered, and the device (01) having a drying line (12), along which the dewatered granulate is dried.

Abstract: A method of producing seat belt webbing is proposed in which the webbing is first woven using at least two synthetic yarns of different colours of which at least one yarn is spun-dyed, and using weaves that are known per se, and that is distinguished in that the webbing is then subjected to treatment in a water-bath containing at least one disperse dye. Seat belt webbing produced in this way and seat belts containing such webbing are also claimed.

Abstract: A method of producing seat belt webbing includes first weaving the webbing using at least two synthetic yarns of different colors of which at least one yarn is spun-dyed, and using weaves that are known, and that is distinguished in that the webbing is then subjected to treatment in a water-bath containing at least one disperse dye. Seat belt webbing produced in this way and seat belts containing such webbing are also included.

Abstract: A method and an apparatus for testing an SDRAM are described. The SDRAM is used as a main memory in the PC, and an additional circuit configuration is accommodated on a plug-in board and has an additional memory in the form of an SRAM and logic circuits. The method according to the invention allows the SDRAM to be tested in a module bank in the running PC to be set deliberately to a test mode. In this case the code for test mode activation is modified by a high-level language program (PASCAL) in accordance with the user requirements, is copied to the additional memory on the plug-in board, and is then called by the high-level language program using MS DOS. After activation of the selected test mode by a code programmed in Assembler, a defined jump is made back to the calling program once again. This allows the use of the test mode provided in the SDRAM in standard PCs and using standard operating systems. This greatly increases the test options for SDRAMs on standard PCs.

Abstract: A brake caliper has a caliper bridge and two legs that are arranged at right angles to the caliper bridge. A housing having a bore for a brake piston is mounted on one leg. The caliper bridge has at least one hollow chamber inside, which is delimited on all sides by supporting walls. Even though the brake caliper exhibits considerable flectional strength it is lightweight.

Abstract: A method and an apparatus for testing an SDRAM are described. The SDRAM is used as a main memory in the PC, and an additional circuit configuration is accommodated on a plug-in board and has an additional memory in the form of an SRAM and logic circuits. The method according to the invention allows the SDRAM to be tested in a module bank in the running PC to be set deliberately to a test mode. In this case the code for test mode activation is modified by a high-level language program (PASCAL) in accordance with the user requirements, is copied to the additional memory on the plug-in board, and is then called by the high-level language program using MS DOS. After activation of the selected test mode by a code programmed in Assembler, a defined jump is made back to the calling program once again. This allows the use of the test mode provided in the SDRAM in standard PCs and using standard operating systems. This greatly increases the test options for SDRAMs on standard PCs.

Abstract: A highly integrated system-on-chip system with a non-volatile memory unit, includes a chip having an integrated MRAM memory unit, and semiconductor layers disposed underneath the MRAM memory unit and functioning merely as carriers for the MRAM memory unit. An integration density of the chip may be increased by using the semiconductor layers for additional integrated circuits.

Abstract: The present invention relates to a disc brake with hydraulically operable brake pads and a mechanical actuating which includes an actuating shaft that is rotatably and sealedly mounted in a bore of a brake housing and acts upon at least one of the brake pads. The present invention focuses on that at least in the area of a shaft duct, a sealing element is provided which is fixed to the actuating shaft so as to rotate along with it and cooperates with at least one associated sealing element and/or mating sealing surfaces in a radial direction. The sealing element bridges a portion of the actuating shaft which is different from the shape of a circle.

Abstract: In a disc brake with automatic adjusting device, a nut (12) is screwed to an axially slidable, unrotatable spindle (11). Nut (12) is connected to a coupling element (13). An auxiliary piston (32) is slidably mounted in a bore (31) of the brake piston (4) and is connected to the nut (12) by an axially lockable snap-in connection (35, 37, 38).

Abstract: In order to obtain a brake caliper for a disk brake which is light and at the same time resistant to bending, the caliper is manufactured from a metal-matrix composite material having embedded ceramic particles. In order not to have to carry out the necessary subsequent machining steps in the hard composite material, it is provided according to the invention that, at least in the area of the brake cylinder and the supply connection, the caliper housing is provided with one or several inserts made of an easy to machine material, preferably an aluminum alloy.