Abstract: An insert element for a vehicle wheel comprises several supporting bodies for supporting the insert element on supporting surfaces of the vehicle wheel. The supporting bodies have a supporting shoulder, which can be brought to bear against a supporting surface of the vehicle wheel, and a fastening extension with an axial hollow channel and with at least one outwardly protruding locking projection, arranged at an axial distance from the supporting shoulder, for engaging behind an installation opening reaching through the supporting surface of the vehicle wheel. The supporting bodies are designed as elastomer components which are elastically deformable in the radial and axial direction and sit with their hollow channel on a supporting core. The supporting cores bear a radially protruding retaining flange and are held on the rear side on the insert element. Each supporting body is held by the retaining flange in a form-fitting manner against being pulled off from the supporting core.

Abstract: A method is provided for producing a population of CD8+ Tc1 and/or Tc2 lymphocytes ex vivo. The method includes stimulating a population of T cells obtained from a subject by contacting the population with an anti-CD3 monoclonal antibody and an antibody that specifically binds to a T cell costimulatory molecule in the presence of a Tc1 or Tc2 supportive environment to form a stimulated population of T cells. The stimulated population of CD8+ T cells is allowed to proliferate in a Tc1 or Tc2 supportive environment. Purified populations of Tc1 and Tc2 cells are disclosed herein, as are methods for their use.