Patents by Inventor Andreas FUNKNER

Andreas FUNKNER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OPTIMIZED NUCLEIC ACID MOLECULES
    Publication number: 20240101608
    Abstract: The present invention provides optimized nucleic acid molecules, methods for optimization of nucleic acid molecules and uses of optimized nucleic acid molecules. A modular design principle is provided that is suitable to generate a nucleic acid, particularly mRNA, which is tailored for a respective application. The nucleic acid molecules of the present invention can be obtained by the versatile combination of multiple modules on nucleic acid level. Such nucleic acid, e.g. mRNA, can be tailored by combining one or more modules, comprising (i) a nucleic acid moiety encoding a polypeptide of interest (e.g. a protein potentially producing a therapeutic outcome) and (ii) at least one further coding or non-coding nucleic acid moiety, e.g.
    Type: Application
    Filed: December 4, 2023
    Publication date: March 28, 2024
    Applicant: CureVac SE
    Inventors: Patrick BAUMHOF, Susanne RAUCH, Aleksandra KOWALCZYK, Johannes LUTZ, Edith JASNY, Benjamin PETSCH, Andreas THESS, Thomas SCHLAKE, Mariola FOTIN-MLECZEK, Regina HEIDENREICH, Sandra LAZZARO, Fatma FUNKNER, Wolfgang GROSSE
  • Method for producing and purifying RNA, comprising at least one step of tangential flow filtration
    Patent number: 11834651
    Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
    Type: Grant
    Filed: May 16, 2023
    Date of Patent: December 5, 2023
    Assignee: CureVac Manufacturing GmbH
    Inventors: Andreas Funkner, Stefanie Dorner, Stefanie Sewing, Johannes Kamm, Norbert Broghammer, Thomas Ketterer, Thorsten Mutzke
  • Method for producing and purifying RNA, comprising at least one step of tangential flow filtration
    Patent number: 11760992
    Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
    Type: Grant
    Filed: August 16, 2022
    Date of Patent: September 19, 2023
    Assignee: CureVac Manufacturing GmbH
    Inventors: Andreas Funkner, Stefanie Dorner, Stefanie Sewing, Johannes Kamm, Norbert Broghammer, Thomas Ketterer, Thorsten Mutzke
  • METHOD FOR PRODUCING AND PURIFYING RNA, COMPRISING AT LEAST ONE STEP OF TANGENTIAL FLOW FILTRATION
    Publication number: 20230287388
    Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
    Type: Application
    Filed: May 16, 2023
    Publication date: September 14, 2023
    Applicant: CureVac Manufacturing GmbH
    Inventors: Andreas FUNKNER, Stefanie DORNER, Stefanie SEWING, Johannes KAMM, Norbert BROGHAMMER, Thomas KETTERER, Thorsten MUTZKE
  • Method for producing and purifying RNA, comprising at least one step of tangential flow filtration
    Patent number: 11667910
    Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
    Type: Grant
    Filed: February 3, 2022
    Date of Patent: June 6, 2023
    Assignee: CureVac Manufacturing GmbH
    Inventors: Andreas Funkner, Stefanie Dorner, Stefanie Sewing, Johannes Kamm, Norbert Broghammer, Thomas Ketterer, Thorsten Mutzke
  • METHOD FOR PRODUCING AND PURIFYING RNA, COMPRISING AT LEAST ONE STEP OF TANGENTIAL FLOW FILTRATION
    Publication number: 20230151352
    Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
    Type: Application
    Filed: August 16, 2022
    Publication date: May 18, 2023
    Applicant: CureVac Manufacturing GmbH
    Inventors: Andreas FUNKNER, Stefanie DORNER, Stefanie SEWING, Johannes KAMM, Norbert BROGHAMMER, Thomas KETTERER, Thorsten MUTZKE
  • METHOD FOR PRODUCING AND PURIFYING RNA, COMPRISING AT LEAST ONE STEP OF TANGENTIAL FLOW FILTRATION
    Publication number: 20220325273
    Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
    Type: Application
    Filed: February 3, 2022
    Publication date: October 13, 2022
    Applicant: CureVac Real Estate GmbH
    Inventors: Andreas FUNKNER, Stefanie DORNER, Stefanie SEWING, Johannes KAMM, Norbert BROGHAMMER, Thomas KETTERER, Thorsten MUTZKE
  • METHOD FOR PURIFYING RNA
    Publication number: 20220290123
    Abstract: The present invention relates to methods for purifying RNA by chromatography under high salt conditions, e.g. by hydrophobic interaction chromatography.
    Type: Application
    Filed: February 9, 2022
    Publication date: September 15, 2022
    Applicant: CureVac AG
    Inventors: Andreas FUNKNER, Stefanie SEWING, Isabel STROBEL, Thorsten MUTZKE
  • METHOD OF RNA IN VITRO TRANSCRIPTION USING A BUFFER CONTAINING A DICARBOXYLIC ACID OR TRICARBOXYLIC ACID OR A SALT THEREOF
    Publication number: 20220119795
    Abstract: The present invention relates to a buffer system comprising a dicarboxylic acid or tricarboxylic acid or a salt thereof for synthesizing RNA molecules as well as a method of RNA in vitro transcription using this buffer system. The present invention also provides the use of this buffer system in RNA in vitro transcription and in the reduction or prevention of precipitates during RNA in vitro transcription.
    Type: Application
    Filed: January 3, 2022
    Publication date: April 21, 2022
    Applicant: CureVac AG
    Inventors: Benyamin YAZDAN PANAH, Aniela WOCHNER, Tilmann ROOS, Andreas FUNKNER, Martin KUNZE
  • Method for purifying RNA
    Patent number: 11279923
    Abstract: The present invention relates to methods for purifying RNA by chromatography under high salt conditions, e.g. by hydrophobic interaction chromatography.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: March 22, 2022
    Assignee: CureVac AG
    Inventors: Andreas Funkner, Stefanie Sewing, Isabel Strobel, Thorsten Mutzke
  • Method for producing and purifying RNA, comprising at least one step of tangential flow filtration
    Patent number: 11274293
    Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: March 15, 2022
    Assignee: CureVac Real Estate GmbH
    Inventors: Andreas Funkner, Stefanie Dorner, Stefanie Sewing, Johannes Kamm, Norbert Broghammer, Thomas Ketterer, Thorsten Mutzke
  • Method of RNA in vitro transcription using a buffer containing a dicarboxylic acid or tricarboxylic acid or a salt thereof
    Patent number: 11248223
    Abstract: The present invention relates to a buffer system comprising a dicarboxylic acid or tricarboxylic acid or a salt thereof for synthesizing RNA molecules as well as a method of RNA in vitro transcription using this buffer system. The present invention also provides the use of this buffer system in RNA in vitro transcription and in the reduction or prevention of precipitates during RNA in vitro transcription.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: February 15, 2022
    Assignee: CureVac AG
    Inventors: Benyamin Yazdan Panah, Aniela Wochner, Tilmann Roos, Andreas Funkner, Martin Kunze
  • METHOD FOR PRODUCING AND PURIFYING RNA, COMPRISING AT LEAST ONE STEP OF TANGENTIAL FLOW FILTRATION
    Publication number: 20210040473
    Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
    Type: Application
    Filed: July 21, 2020
    Publication date: February 11, 2021
    Applicant: CureVac Real Estate GmbH
    Inventors: Andreas FUNKNER, Stefanie DORNER, Stefanie SEWING, Johannes KAMM, Norbert BROGHAMMER, Thomas KETTERER, Thorsten MUTZKE
  • METHOD FOR PURIFYING RNA
    Publication number: 20200318097
    Abstract: The present invention relates to methods for purifying RNA by chromatography under high salt conditions, e.g. by hydrophobic interaction chromatography.
    Type: Application
    Filed: November 28, 2017
    Publication date: October 8, 2020
    Inventors: Andreas FUNKNER, Stefanie SEWING, Isabel STROBEL, Thorsten MUTZKE
  • Method for producing and purifying RNA, comprising at least one step of tangential flow filtration
    Patent number: 10760070
    Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
    Type: Grant
    Filed: May 30, 2016
    Date of Patent: September 1, 2020
    Assignee: CureVac Real Estate GmbH
    Inventors: Andreas Funkner, Stefanie Dorner, Stefanie Sewing, Johannes Kamm, Norbert Broghammer, Thomas Ketterer, Thorsten Mutzke
  • METHOD OF RNA IN VITRO TRANSCRIPTION USING A BUFFER CONTAINING A DICARBOXYLIC ACID OR TRICARBOXYLIC ACID OR A SALT THEREOF
    Publication number: 20190010485
    Abstract: The present invention relates to a buffer system comprising a dicarboxylic acid or tricarboxylic acid or a salt thereof for synthesizing RNA molecules as well as a method of RNA in vitro transcription using this buffer system. The present invention also provides the use of this buffer system in RNA in vitro transcription and in the reduction or prevention of precipitates during RNA in vitro transcription.
    Type: Application
    Filed: December 23, 2016
    Publication date: January 10, 2019
    Inventors: Benyamin YAZDAN PANAH, Aniela WOCHNER, Tilmann ROOS, Andreas FUNKNER, Martin KUNZE
  • A METHOD FOR PRODUCING AND PURIFYING RNA, COMPRISING AT LEAST ONE STEP OF TANGENTIAL FLOW FILTRATION
    Publication number: 20180298372
    Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
    Type: Application
    Filed: May 30, 2016
    Publication date: October 18, 2018
    Inventors: Andreas FUNKNER, Stefanie DORNER, Stefanie SEWING, Johannes KAMM, Norbert BROGHAMMER, Thomas KETTERER, Thorsten MUTZKE