Patents by Inventor Andreas Geipel
Andreas Geipel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230227907Abstract: The technology provided herein relates to multiplex methods and kits for detecting different analytes in a sample in parallel by sequential signal-encoding of said analytes, as well as in vitro methods for screening, identifying and/or testing a substance and/or drug and in vitro methods for diagnosis of a disease, and an optical multiplexing system.Type: ApplicationFiled: June 18, 2021Publication date: July 20, 2023Applicant: Resolve BioSciences GmbHInventors: Andreas Geipel, Frank Reinecke, Christian Korfhage
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Publication number: 20220235402Abstract: The present invention is directed to a method of sequential signal-encoding of analytes in a sample, a use of a set of decoding oligonucleotides to sequentially signal-encode analytes in a sample, and to a kit for sequentially signal-encoding of analytes in a sample.Type: ApplicationFiled: June 18, 2020Publication date: July 28, 2022Applicant: RESOLVE BIOSCIENCES GMBHInventors: Andreas GEIPEL, Frank REINECKE, Christian KORFHAGE, Nadine JAGEMANN, Vanessa MOELLERING
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Publication number: 20220205028Abstract: The technology provided herein relates to multiplex methods and kits for detecting different analytes and different subgroups/variations of an analyte in a sample, for example in parallel by sequential signal-encoding of said analytes, as well as in vitro methods for screening, identifying and/or testing a substance and/or drug and in vitro methods for diagnosis of a disease, and an optical multiplexing system.Type: ApplicationFiled: December 17, 2021Publication date: June 30, 2022Applicant: Resolve Biosciences GMBHInventors: Andreas GEIPEL, Christian KORFHAGE, Frank REINECKE
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Patent number: 10556057Abstract: Micro-fluidic chambers for use in a liquid medicament delivery system, include a bottom substrate and a top cover, the top cover being spaced from the bottom substrate so as to define a height of the chamber, wherein, one or more walls or fillings are positioned in the chamber, the walls or fillings defining a fluid channel there between such that the fluid channel extends from an inlet conduit to an inlet of the chamber to an outlet conduit connected to an outlet of the chamber, wherein, each of the walls or fillings has a height less than the height of the chamber so as to define a fluid gap between a top surface of each wall or filling and the top cover; and wherein, the dimensions of the walls or fillings and the chamber are such that the fluid gap will be filled with liquid by capillary forces via the fluid channel when liquid is introduced into the fluid chamber.Type: GrantFiled: February 14, 2017Date of Patent: February 11, 2020Assignee: Roche Diabetes Care, IncInventors: Andreas Geipel, Christoph Huwiler, Florian Kühni
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Patent number: 10525211Abstract: An infusion pump device and method for filling a fluidic system of the infusion pump with liquid medicament prior to infusion operation is presented. A control unit causes the infusion pump to: (a) bring a pump to an initial state; (b) switch a valve to a first state connecting a secondary reservoir to a first conduit and a primary reservoir; (c) retrieve medicament from the primary reservoir; (d) switch the valve to a second state connecting the secondary reservoir to a second downstream conduit; (e) expel the secondary reservoir contents into the second downstream conduit; (f) switch the valve to the first state; (g) retrieve the primary reservoir medicament; (h) switch the valve to the second state; and (i) expel the secondary reservoir contents into the second downstream conduit by shifting a piston to the initial position.Type: GrantFiled: October 9, 2013Date of Patent: January 7, 2020Assignee: Roche Diabetes Care, Inc.Inventors: Andreas Geipel, Joerg Dogwiler, Ulrich Haueter, Simon Scheurer, Rudolf Zihlmann, David Teutsch, Florian Kuehni, Reto Schaltegger
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Patent number: 10398853Abstract: Bubble traps for removing bubbles from a stream of liquid and flexible containers comprising such bubble traps are disclosed. The bubble trap includes a containment chamber fluidly coupled to an outlet conduit. At least one grate is disposed between the containment chamber and the outlet conduit. The at least one grate includes a plurality of grate inlets formed in a grate wall and fluidly coupled to the outlet conduit with a plurality of grate conduits such that the containment chamber is fluidly coupled to the outlet conduit. The grate traps bubbles entrained in the stream of liquid flowing from the containment chamber to the outlet conduit in the containment chamber when the bubbles are greater than or equal to a diameter of the grate inlets.Type: GrantFiled: December 12, 2016Date of Patent: September 3, 2019Assignee: Roche Diagnostics International AGInventors: Christoph Huwiler, Florian Kuhni, Andreas Geipel
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Patent number: 10022496Abstract: A sensor device for use in a medical fluid delivery system, or an infusion pump device, comprises a fluidic chamber with a deformable cover closing at least an area of the chamber and an optical detection system comprising at least one light emitter for emitting one or more incident light beams and a sensor unit for monitoring one or more reflected light beams is presented. In a pressurized state of the fluidic chamber, the deformable cover is deformed such that it forms an inflexion point area within the deformed cover. The one or more incident light beams emitted by the light emitter are directed on the cover such that the one or more incident light beams are reflected essentially in the inflexion point area.Type: GrantFiled: January 28, 2016Date of Patent: July 17, 2018Assignee: Roche Diabetes Care, Inc.Inventors: Andreas Geipel, Pascal Grossenbacher, Philipp Michel, Ulrich Haueter
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Patent number: 9724267Abstract: A container for storing a medical or pharmaceutical liquid comprising a storage compartment for storing the liquid comprising, an inlet opening for filling the storage compartment and an outlet opening for discharging liquid out of the storage compartment is presented. A hydrophilic membrane layer is arranged within the storage compartment which is gas-tight in a wet condition and which at least covers the outlet opening and contacts the liquid stored within the storage compartment. A dosing assembly and a device for automated release of a medical or pharmaceutical liquid comprising and/or capable of using at least one container are also disclosed.Type: GrantFiled: May 15, 2013Date of Patent: August 8, 2017Assignee: Roche Diagnostics International AGInventors: Martin Wyss, Rudolf Zihlmann, Gerald Studer, Andreas Geipel, Davide Crotta
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Publication number: 20170209643Abstract: Micro-fluidic chambers for use in a liquid medicament delivery system, include a bottom substrate and a top cover, the top cover being spaced from the bottom substrate so as to define a height of the chamber, wherein, one or more walls or fillings are positioned in the chamber, the walls or fillings defining a fluid channel there between such that the fluid channel extends from an inlet conduit to an inlet of the chamber to an outlet conduit connected to an outlet of the chamber, wherein, each of the walls or fillings has a height less than the height of the chamber so as to define a fluid gap between a top surface of each wall or filling and the top cover; and wherein, the dimensions of the walls or fillings and the chamber are such that the fluid gap will be filled with liquid by capillary forces via the fluid channel when liquid is introduced into the fluid chamberType: ApplicationFiled: February 14, 2017Publication date: July 27, 2017Applicant: Roche Diagnostics International AGInventors: Andreas Geipel, Christoph Huwiler, Florian Kühni
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Publication number: 20170087309Abstract: Bubble traps for removing bubbles from a stream of liquid and flexible containers comprising such bubble traps are disclosed. The bubble trap includes a containment chamber fluidly coupled to an outlet conduit. At least one grate is disposed between the containment chamber and the outlet conduit. The at least one grate includes a plurality of grate inlets formed in a grate wall and fluidly coupled to the outlet conduit with a plurality of grate conduits such that the containment chamber is fluidly coupled to the outlet conduit. The grate traps bubbles entrained in the stream of liquid flowing from the containment chamber to the outlet conduit in the containment chamber when the bubbles are greater than or equal to a diameter of the grate inlets.Type: ApplicationFiled: December 12, 2016Publication date: March 30, 2017Inventors: Christoph Huwiler, Florian Kuhni, Andreas Geipel
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Patent number: 9603998Abstract: Micro-fluidic chambers for use in a liquid medicament delivery system, include a bottom substrate and a top cover, the top cover being spaced from the bottom substrate so as to define a height of the chamber, wherein, one or more walls or fillings are positioned in the chamber, the walls or fillings defining a fluid channel there between such that the fluid channel extends from an inlet of the chamber to an outlet of the chamber, wherein, each of the walls or fillings has a height less than the height of the chamber so as to define a fluid gap between a top surface of each wall or filling and the top cover; and wherein, the dimensions of the walls or fillings and the chamber are such that the fluid gap will be filled with liquid by capillary forces via the fluid channel when liquid is introduced into the fluid chamber.Type: GrantFiled: September 8, 2010Date of Patent: March 28, 2017Assignee: Roche Diagnostics International AGInventors: Andreas Geipel, Christoph Huwiler, Florian Kühni
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Patent number: 9555197Abstract: Bubble traps for removing bubbles from a stream of liquid and flexible containers comprising such bubble traps are disclosed. The bubble trap includes a containment chamber fluidly coupled to an outlet conduit. At least one grate is disposed between the containment chamber and the outlet conduit. The at least one grate includes a plurality of grate inlets formed in a grate wall and fluidly coupled to the outlet conduit with a plurality of grate conduits such that the containment chamber is fluidly coupled to the outlet conduit. The grate traps bubbles entrained in the stream of liquid flowing from the containment chamber to the outlet conduit in the containment chamber when the bubbles are greater than or equal to a diameter of the grate inlets.Type: GrantFiled: May 9, 2014Date of Patent: January 31, 2017Assignee: Roche Diagnostics International AGInventors: Christoph Huwiler, Florian Kuhni, Andreas Geipel
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Patent number: 9446193Abstract: A dosing unit for an ambulatory infusion pump device is presented. The dosing unit comprises a cylinder pump with a cylinder and a piston arranged in the cylinder. The piston has a shaft with a first threaded segment interacting with a threaded portion of the cylinder and can be displaced along a longitudinal axis of the cylinder by rotating the piston in regard to the cylinder around the axis. Furthermore, the piston allows for the relative or absolute determination of the longitudinal and/or rotational displacement of the piston in regard to the cylinder. In one embodiment, the piston shaft comprises a second segment provided with optically detectable markings that allow the monitoring of the longitudinal and/or rotational displacement of the piston in regard to the cylinder.Type: GrantFiled: October 9, 2013Date of Patent: September 20, 2016Assignee: Roche Diagnostics International AGInventors: Andreas Geipel, Joerg Dogwiler, Ulrich Haueter, Simon Scheurer, Rudolf Zihlmann, David Teutsch, Florian Kuehni, Reto Schaltegger
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Patent number: 9402951Abstract: An infusion pump device comprising a primary liquid medicament reservoir, a pump with a secondary reservoir to retrieve medicament from the primary reservoir and to subsequently dose the medicament from the secondary reservoir in adjustable volumes (Vdose,i) to a downstream conduit and a control unit to control the operation of the infusion pump device is presented. For metering the volumes (Vdose,i), the control unit causes the infusion pump device to: (a) determine a maximum refill level (VC,max) for the secondary reservoir, based on external parameters, wherein the maximum refill level does not exceed the maximum capacity of the secondary reservoir; (b) fill the secondary reservoir with medicament from the primary reservoir to the maximum refill level (VC,max); (c) meter and convey the medicament volumes to the downstream conduit; (d) if the secondary reservoir becomes empty, refill the secondary reservoir as in step (b) and continue with step (c).Type: GrantFiled: October 9, 2013Date of Patent: August 2, 2016Assignee: Roche Diagnostics International AGInventors: Andreas Geipel, Joerg Dogwiler, Ulrich Haueter, Simon Scheurer, Rudolf Zihlmann, David Teutsch, Florian Kuehni, Reto Schaltegger
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Publication number: 20160144111Abstract: A sensor device for use in a medical fluid delivery system, or an infusion pump device, comprises a fluidic chamber with a deformable cover closing at least an area of the chamber and an optical detection system comprising at least one light emitter for emitting one or more incident light beams and a sensor unit for monitoring one or more reflected light beams is presented. In a pressurized state of the fluidic chamber, the deformable cover is deformed such that it forms an inflexion point area within the deformed cover. The one or more incident light beams emitted by the light emitter are directed on the cover such that the one or more incident light beams are reflected essentially in the inflexion point area.Type: ApplicationFiled: January 28, 2016Publication date: May 26, 2016Inventors: Andreas Geipel, Pascal Grossenbacher, Philipp Michel, Ulrich Haueter
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Patent number: 9283319Abstract: Cannula assemblies with pressure sensors made of stacked coplanar layers and ambulatory infusion systems comprising the same are disclosed. The cannula assemblies include a hub and an infusion cannula. The hub includes a pressure sensor and a fluid channel fluidly coupled to the infusion cannula. The pressure sensor is formed from a stack of coplanar layers including a top layer, a base layer an electrode layer and a counter electrode layer. The fluid channel is positioned between the top layer and the base layer. The electrode layer is positioned between the top layer and the base layer and coupled to the fluid channel. The counter-electrode layer is positioned between the top layer and the electrode layer. A spacer layer having a through cut-out defining an electrode cavity is disposed between the top layer and the base layer such that the electrode layer extends across the electrode cavity.Type: GrantFiled: October 19, 2012Date of Patent: March 15, 2016Assignee: ROCHE DIAGNOSTICS INTERNATIONAL AGInventors: Andreas Geipel, Florian Kuhni, Christoph Huwiler, Ulrich Haueter
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Patent number: 9248230Abstract: A sensor device for use in a medical fluid delivery system, or an infusion pump device, comprises a fluidic chamber with a deformable cover closing at least an area of the chamber and an optical detection system comprising at least one light emitter for emitting one or more incident light beams and a sensor unit for monitoring one or more reflected light beams is presented. In a pressurized state of the fluidic chamber, the deformable cover is deformed such that it forms an inflexion point area within the deformed cover. The one or more incident light beams emitted by the light emitter are directed on the cover such that the one or more incident light beams are reflected essentially in the inflexion point area.Type: GrantFiled: September 13, 2013Date of Patent: February 2, 2016Assignee: Roche Diagnostics International AGInventors: Andreas Geipel, Pascal Grossenbacher, Philipp Michel, Ulrich Haueter
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Patent number: 8943894Abstract: A device for detecting pressure and/or temperature changes in a fluid-channel and method thereof are disclosed. The device includes a main duct with an inlet and an outlet, a branch ductwork with a first branch end branching off the main duct downwards the inlet and with a second branch end discharging into the main duct upwards the outlet, and at least one dead-end channel with a first end that branches off the branch ductwork and a second closed end. The dead-end channel is adapted to trap a gas bubble within the dead-end channel when the device is primed or filled with a liquid fluid, wherein the gas bubble changes its size or position if a change in pressure or temperature occurs in the device.Type: GrantFiled: February 4, 2013Date of Patent: February 3, 2015Assignee: Roche Diagnostics International AGInventor: Andreas Geipel
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Publication number: 20140378943Abstract: Methods and devices for drug infusion and for storing a drug container. The methods and devices can include ambulatory infusion systems and dosing units. The dosing units can have and an inlet port for attachment to an external liquid drug container, an outlet port, a pump kernel, and a control valve.Type: ApplicationFiled: June 20, 2014Publication date: December 25, 2014Inventor: Andreas Geipel
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Publication number: 20140243782Abstract: Bubble traps for removing bubbles from a stream of liquid and flexible containers comprising such bubble traps are disclosed. The bubble trap includes a containment chamber fluidly coupled to an outlet conduit. At least one grate is disposed between the containment chamber and the outlet conduit. The at least one grate includes a plurality of grate inlets formed in a grate wall and fluidly coupled to the outlet conduit with a plurality of grate conduits such that the containment chamber is fluidly coupled to the outlet conduit. The grate traps bubbles entrained in the stream of liquid flowing from the containment chamber to the outlet conduit in the containment chamber when the bubbles are greater than or equal to a diameter of the grate inlets.Type: ApplicationFiled: May 9, 2014Publication date: August 28, 2014Applicant: Roche Diagnostics International AGInventors: Christoph Huwiler, Florian Kuhni, Andreas Geipel