Abstract: The present invention relates to delayed release pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.

Abstract: The present invention relates to delayed release pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.

Abstract: A device is provided comprising an expansion machine for generating mechanical energy by expanding vapor of a working medium; a generator connected to a shaft of the expansion machine and used for generating electric energy from mechanical energy of the expansion machine; wherein the expansion machine and the generator form a structural unit with an exhaust vapor chamber between the expansion machine and the generator, and wherein, when the expansion machine is in operation, working medium expanded into the exhaust vapor chamber contacts the generator; and means for feeding, in particular injecting, a liquid working medium into the exhaust vapor chamber. Also provided is an ORC device comprising the device and a method for operating the device.

Abstract: Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula I: wherein R is —OH or —O—CH3. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula I. Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula I optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula I.

Abstract: Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula I: wherein R is —OH or —O—CH3. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula I. Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula I optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula I.

Abstract: Compounds of formula: are described herein. The compounds selectively complex copper and are therefore useful both abiotically for measuring and detecting small amounts of copper and, in biological systems, for treating diseases associated with inappropriate copper levels, such as Wilson's disease and gastric cancer.

Abstract: A device is provided comprising an expansion machine for generating mechanical energy by expanding vapor of a working medium; a generator connected to a shaft of the expansion machine and used for generating electric energy from mechanical energy of the expansion machine; wherein the expansion machine and the generator form a structural unit with an exhaust vapor chamber between the expansion machine and the generator, and wherein, when the expansion machine is in operation, working medium expanded into the exhaust vapor chamber contacts the generator; and means for feeding, in particular injecting, a liquid working medium into the exhaust vapor chamber. Also provided is an ORC device comprising the device and a method for operating the device.

Abstract: The invention relates to a device comprising: an expansion machine for generating mechanical energy by expanding vapor of a working medium; a generator connected to a shaft of the expansion machine and used for generating electric energy from mechanical energy of the expansion machine; wherein the expansion machine and the generator form a structural unit with an exhaust vapor chamber between the expansion machine and the generator, and wherein, when the expansion machine is in operation, working medium expanded into the exhaust vapor chamber contacts the generator; and means for feeding, in particular injecting, a liquid working medium into the exhaust vapor chamber. The invention also relates to an ORC device comprising the device according to the present invention and to a method for operating the device according to the present invention.

Abstract: Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula I: wherein R is —OH or —O—CH3. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula I. Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula I optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula I.

Abstract: The present invention is directed to stable linaclotide compositions and methods of treating gastrointestinal disorders in patients in need thereof by providing the stable linaclotide compositions.

Abstract: The present invention relates to a method for controlling a pump, in particular a centrifugal pump, during pumping of a liquid, comprising the following steps: fixing a setpoint value of a flow rate of the pump; measuring an inlet pressure of the liquid upstream of the pump and an outlet pressure of the liquid downstream of the pump; determining a setpoint value of a rotational speed of the pump from a performance map of the pump, wherein the fixed setpoint value of the flow rate and a difference between the outlet pressure and the inlet pressure are incorporated into the performance map as input values; and setting the rotational speed of the pump to the setpoint value of the rotational speed. Furthermore, the invention relates to a corresponding device for controlling a pump.

Abstract: The invention relates to a method for detecting a leak in a thermodynamic cycle device with a condenser for condensing vaporous working medium, comprising the following steps: determining sub-cooling of the working medium in the condenser, wherein sub-cooling is determined as a difference between a condensation temperature in the condenser and a temperature of a liquid working medium exiting the condenser; detecting a leak in the event that the sub-cooling determined differs from a setpoint value for the sub-cooling or in the event that a filling quantity of the working medium in the thermodynamic cycle device, being determined from the determined sub-cooling, differs from a setpoint value for the filling quantity. The invention further relates to a corresponding computer program product and to a corresponding device.

Abstract: The invention relates to a method for regulating a condenser in a thermal cycle apparatus, in particular in an ORC apparatus, wherein the thermal cycle apparatus comprises a feed pump for conveying liquid working medium with an increase in pressure to an evaporator, the evaporator for evaporating and optionally additionally superheating the working medium with a supply of heat, an expansion machine for generating mechanical energy by expansion of the evaporated working medium, a generator for at least partially converting the mechanical energy into electrical energy, and the condenser for condensing the expanded working medium, and wherein the method comprises the following steps: determining a rotational speed of the generator or of the expansion machine; determining, without the use of a temperature sensor, a temperature of cooling air supplied from the condenser; determining from the determined generator or expansion machine rotational speed and the determined cooling air temperature, a condensation setpoi

Abstract: The invention relates to a thermodynamic cycle apparatus, comprising: a working medium; an evaporator for evaporating the working medium; an expansion machine; a condenser, and a pump, wherein the geometrical arrangement of the evaporator is selected such that the condensed working medium can flow from the condenser to the evaporator by force of gravity and the working medium can circulate in a closed circuit via the evaporator and the condenser wherein a predetermined head height of the liquid working medium can be provided at the pump. The invention additionally relates to a method of starting the thermodynamic cycle apparatus the method comprising the following steps: applying heat to the evaporator and evaporating the working medium in the evaporator, wherein the working medium is caused to flow to the condenser; condensing the working medium in the condenser; starting the pump when a predetermined head height of the working medium at the pump is reached or exceeded.

Abstract: The invention relates to a thermodynamic circuit process device comprising a working medium having a lubricant additive; an expansion machine (5) for converting enthalpy in the working medium into mechanical energy; a multi-stage pressure-increasing apparatus (1) for the step-by-step pressurization of the working medium; a means (4) for branching a part of the working medium between two stages of the multi-stage pressure-increasing apparatus (1); and a means (4) for feeding the branched off part of the working medium to one or a plurality of bearing points of the expansion machine. The invention further relates to a corresponding method for lubricating an expansion machine in a thermodynamic circuit process device.

Abstract: The present invention is directed to stable linaclotide compositions and methods of treating gastrointestinal disorders in patients in need thereof by providing the stable linaclotide compositions.

Abstract: The invention relates to a method for detecting a leak in a thermodynamic cycle device with a condenser for condensing vaporous working medium, comprising the following steps: determining sub-cooling of the working medium in the condenser, wherein sub-cooling is determined as a difference between a condensation temperature in the condenser and a temperature of a liquid working medium exiting the condenser; detecting a leak in the event that the sub-cooling determined differs from a setpoint value for the sub-cooling or in the event that a filling quantity of the working medium in the thermodynamic cycle device, being determined from the determined sub-cooling, differs from a setpoint value for the filling quantity. The invention further relates to a corresponding computer program product and to a corresponding device.

Abstract: The invention relates to a method for regulating a condenser in a thermal cycle apparatus, in particular in an ORC apparatus, wherein the thermal cycle apparatus comprises a feed pump for conveying liquid working medium with an increase in pressure to an evaporator, the evaporator for evaporating and optionally additionally superheating the working medium with a supply of heat, an expansion machine for generating mechanical energy by expansion of the evaporated working medium, a generator for at least partially converting the mechanical energy into electrical energy, and the condenser for condensing the expanded working medium, and wherein the method comprises the following steps: determining a rotational speed of the generator or of the expansion machine; determining, without the use of a temperature sensor, a temperature of cooling air supplied from the condenser; determining from the determined generator or expansion machine rotational speed and the determined cooling air temperature, a condensation setpoi

Abstract: The present invention is directed to stable linaclotide compositions and methods of treating gastrointestinal disorders in patients in need thereof by providing the stable linaclotide compositions.

Abstract: The invention relates to a device comprising: an expansion machine for generating mechanical energy by expanding vapor of a working medium; a generator connected to a shaft of the expansion machine and used for generating electric energy from mechanical energy of the expansion machine; wherein the expansion machine and the generator form a structural unit with an exhaust vapor chamber between the expansion machine and the generator, and wherein, when the expansion machine is in operation, working medium expanded into the exhaust vapor chamber contacts the generator; and means for feeding, in particular injecting, a liquid working medium into the exhaust vapor chamber. The invention also relates to an ORC device comprising the device according to the present invention and to a method for operating the device according to the present invention.