Patents by Inventor Andreas Gschwind

Andreas Gschwind has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130078247
    Abstract: Bispecific binding molecules binding to both DII4 and Ang2, preferably in the form of immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing the same and their use in the treatment of diseases that are associated with DII4- and/or Ang2-mediated effects on angiogenesis are disclosed. Further, nucleic acids encoding bispecific binding molecules, host cells and methods for preparing same are also described.
    Type: Application
    Filed: March 29, 2012
    Publication date: March 28, 2013
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Andreas GSCHWIND, Rene Georg OTT, Joachim BOUCNEAU, Marie-Ange BUYSE, Erik DEPLA
  • Publication number: 20130078248
    Abstract: Bispecific binding molecules binding to both VEGF and Ang2, preferably in the form of immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing the same and their use in the treatment of diseases that are associated with VEGF- and/or Ang2-mediated effects on angiogenesis are disclosed. Further, nucleic acids encoding bispecific binding molecules, host cells and methods for preparing same are also described.
    Type: Application
    Filed: March 29, 2012
    Publication date: March 28, 2013
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Andreas GSCHWIND, Rene Georg OTT, Joachim BOUCNEAU, Marie-Ange BUYSE, Erik DEPLA
  • Publication number: 20120225081
    Abstract: VEGF-binding molecules, preferably VEGF-binding immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF-mediated effects on angiogenesis. Nucleic acids encoding VEGF-binding molecules, host cells and methods for preparing same.
    Type: Application
    Filed: September 1, 2011
    Publication date: September 6, 2012
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Andreas GSCHWIND, Eric BORGES, Joachim BOUCNEAU, Evelyn DE TAVERNIER, Joost KOLKMAN, Pascal MERCHIERS
  • Publication number: 20110195494
    Abstract: DII4-binding molecules, preferably DII4-binding immunoglobulin single variable domains like VHHs and VHs, pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with DII4-mediated effects on angiogenesis. Bispecific DII4-binding molecules that also bind to VEGF-A. Nucleic acids encoding DII4-binding molecules, host cells and methods for preparing same.
    Type: Application
    Filed: September 30, 2010
    Publication date: August 11, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Eric BORGES, Andreas GSCHWIND, Joachim BOUCNEAU, Evelyn DE TAVERNIER, Joost KOLKMAN, Pascal MERCHIERS, Diane VAN HOORICK
  • Publication number: 20110172398
    Abstract: Bispecific binding molecules, in particular immunoglobulin single variable domains such as VHHs and domain antibodies, comprising a VEGF-binding component and a Dll4-binding component in one molecule. Pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF- and Dll4-mediated effects on angiogenesis. Nucleic acids encoding the bispecific binding molecules, host cells and methods for preparing same.
    Type: Application
    Filed: September 30, 2010
    Publication date: July 14, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Eric BORGES, Andreas GSCHWIND, Joachim BOUCNEAU, Evelyn DE TAVERNIER, Joost KOLKMAN, Pascal MERCHIERS, Diane VAN HOORICK
  • Publication number: 20090292007
    Abstract: The present invention relates to the modulation of transactivation of receptor tyrosine kinases by G protein or G protein-coupled receptor (GPCR) mediated signal transduction in a cell or an organism comprising inhibiting the activity of the metalloprotease TACE/ADAM17 and/or the activity of the receptor tyrosine kinase ligand amphiregulin.
    Type: Application
    Filed: March 9, 2009
    Publication date: November 26, 2009
    Applicant: Max-Planck-Gesellschaft zur Foerderung Der Wissenschaften e.V.
    Inventors: Axel Ullrich, Andreas Gschwind, Stefan Hart
  • Patent number: 7524495
    Abstract: The present invention relates to the modulation of transactivation of receptor tyrosine kinases by G protein or G protein-coupled receptor (GPCR) mediated signal transduction in a cell or an organism comprising inhibiting the activity of the metalloprotease TACE/ADAM17 and/or the activity of the receptor tyrosine kinase ligand amphiregulin.
    Type: Grant
    Filed: February 20, 2004
    Date of Patent: April 28, 2009
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Axel Ullrich, Andreas Gschwind, Stefan Hart
  • Publication number: 20060246448
    Abstract: The present invention relates to the modulation of transactivation of receptor tyrosine kinases by G protein or G protein-coupled receptor (GPCR) mediated signal transduction in a cell or an organism comprising inhibiting the activity of the metalloprotease TACE/ADAM17 and/or the activity of the receptor tyrosine kinase ligand amphiregulin.
    Type: Application
    Filed: February 20, 2004
    Publication date: November 2, 2006
    Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Axel Ullrich, Andreas Gschwind, Stefan Hart
  • Publication number: 20050176633
    Abstract: The present invention relates to the use of a compound which is capable of inhibiting activation of a growth factor receptor of the EGFR-family for the prevention or treatment of processes associated with increased G-protein mediated signal transduction.
    Type: Application
    Filed: March 7, 2003
    Publication date: August 11, 2005
    Inventors: Axel Ullrich, Beatrix Schaefer, Oliver Fischer, Andreas Gschwind, Michael Leserer