Abstract: A plurality of modules are simultaneously positioned at locations that correspond to different angiosomes. Each of these modules has a front surface shaped and dimensioned for contacting a person's skin, a plurality of different-wavelength light sources aimed in a forward direction, and a plurality of light detectors aimed to detect light arriving from in front of the front surface. Each module is supported by a support structure (e.g., a strap or a clip) that is shaped and dimensioned to hold the front surface adjacent to the person's skin at a respective position. Perfusion in each of the angiosomes is monitored using these modules, and the surgeon can rely on this information to guide his or her intervention.

Abstract: A plurality of modules are simultaneously positioned at locations that correspond to different angiosomes. Each of these modules has a front surface shaped and dimensioned for contacting a person's skin, a plurality of different-wavelength light sources aimed in a forward direction, and a plurality of light detectors aimed to detect light arriving from in front of the front surface. Each module is supported by a support structure (e.g., a strap or a clip) that is shaped and dimensioned to hold the front surface adjacent to the person's skin at a respective position. Perfusion in each of the angiosomes is monitored using these modules, and the surgeon can rely on this information to guide his or her intervention.

Abstract: Systemic lupus erythematosus (SLE) can be diagnosed by affixing a plurality of light sources and a plurality of light detectors against the subject's body near a joint, and sequentially transmitting light from each of the plurality of light sources into the subject's body. Signals are acquired from each of the plurality of light detectors. The rise time of the acquired signals that occurs in response to an inflation of a pressure cuff is determined, and an indication of whether the joint is affected by SLE is made based on the determined rise time. In some embodiments, a plateau time of the acquired signals is also acquired, and the indication of whether the joint is affected by SLE is made based on the determined rise time and the determined plateau time.

Abstract: The disclosed subject matter includes optical tomographic systems for acquiring and displaying dynamic data representing changes in a target tissue sample to external provocation. For example, the disclosed devices, methods and systems may be used for quantifying dynamic vascular changes caused by imposed blood pressure changes for diagnosing peripheral artery disease.

Abstract: A probe and connected system provide ultrasound imaging and optical tomographic imaging of the prostate. A transrectal component carries ultrasound and optical sources and detectors movably connected to a reference element called a probe carrier that provide a reference frame to coregister anatomical and optical tomographic image data.

Abstract: The disclosed subject matter includes optical tomographic systems for acquiring and displaying dynamic data representing changes in a target tissue sample to external provocation. For example, the disclosed devices, methods and systems may be used for quantifying dynamic vascular changes caused by imposed blood pressure changes for diagnosing peripheral artery disease.

Abstract: An imaging interface for diffuse optical tomography of breast includes a plurality of concentric rings. Each concentric ring can include a plurality of optical input/output apertures arranged on a radially inner surface thereof. The rings can have different inner and outer diameters from each other and can be arranged in a stacked configuration. The rings can translate independently of each other along a central axis of the stack. During imaging the breast is inserted into an inner region of the stacked rings. The rings can be translated such that the optical input/output apertures are brought into touch contact (i.e., non-compressing contact) with the surface of the breast, so as to accommodate different size breasts. The rings may be translated such that the spacing between adjacent rings is increased for large breasts and reduced for smaller breasts. Rings may be removed or additional rings added to further accommodate additional breast sizes.

Abstract: An optical imaging device and system can be used to visualize and/or provide a quantitative measure of changes in patient vasculature, for example, to monitor responsiveness of a tumor to a particular chemotherapy treatment. A plurality of detectors (e.g., two) are spaced from a plurality of substantially monochromatic light sources (e.g., four) on an interrogation face of the handheld device. Wavelengths of light in the near-infrared range are used to measure the content of hemoglobin, water, and lipid of the tissue that the interrogation face comes in contact with. The light can be modulated so that the effect of ambient light is not minimized or at least reduced. The detected signal is amplified, filtered, and digitized within the device by appropriate electronics. In embodiments, handheld device can include a wireless communication module, such as a Bluetooth device, for wireless transmission of data to/from the remote processor or computer.

Abstract: A plurality of modules are simultaneously positioned at locations that correspond to different angiosomes. Each of these modules has a front surface shaped and dimensioned for contacting a person's skin, a plurality of different-wavelength light sources aimed in a forward direction, and a plurality of light detectors aimed to detect light arriving from in front of the front surface. Each module is supported by a support structure (e.g., a strap or a clip) that is shaped and dimensioned to hold the front surface adjacent to the person's skin at a respective position. Perfusion in each of the angiosomes is monitored using these modules, and the surgeon can rely on this information to guide his or her intervention.

Abstract: A multispectral bioluminescence optical tomography algorithm makes use of a partial differential equation (PDE) constrained approach. A sequential quadratic programming (SQP) method is demonstrated that allows for solving both forward and inverse problems at once by updating the forward and inverse variables simultaneously at each step of the optimization iterations. Light propagation in biological tissue is modeled by using the equation of radiative transfer (ERT) and performance of the ERT-based PDE-constrained approach is modeled through numerical and experimental studies.

Abstract: A multispectral bioluminescence optical tomography algorithm makes use of a partial differential equation (PDE) constrained approach. A sequential quadratic programming (SQP) method is demonstrated that allows for solving both forward and inverse problems at once by updating the forward and inverse variables simultaneously at each step of the optimization iterations. Light propagation in biological tissue is modeled by using the equation of radiative transfer (ERT) and performance of the ERT-based PDE-constrained approach is modeled through numerical and experimental studies.

Abstract: The disclosed subject matter includes optical tomographic systems for acquiring and displaying dynamic data representing changes in a target tissue sample to external provocation. For example, the disclosed devices, methods and systems may be used for quantifying dynamic vascular changes caused by imposed blood pressure changes for diagnosing peripheral artery disease.

Abstract: An optical imaging device and system can be used to visualize and/or provide a quantitative measure of changes in patient vasculature, for example, to monitor responsiveness of a tumor to a particular chemotherapy treatment. A plurality of detectors (e.g., two) are spaced from a plurality of substantially monochromatic light sources (e.g., four) on an interrogation face of the handheld device. Wavelengths of light in the near-infrared range are used to measure the content of hemoglobin, water, and lipid of the tissue that the interrogation face comes in contact with. The light can be modulated so that the effect of ambient light is not minimized or at least reduced. The detected signal is amplified, filtered, and digitized within the device by appropriate electronics. In embodiments, handheld device can include a wireless communication module, such as a Bluetooth device, for wireless transmission of data to/from the remote processor or computer.

Abstract: The disclosed subject matter includes optical tomographic systems for acquiring and displaying dynamic data representing changes in a target tissue sample to external provocation. For example, the disclosed devices, methods and systems may be used for quantifying dynamic vascular changes caused by imposed blood pressure changes for diagnosing peripheral artery disease.

Abstract: The disclosed subject matter includes optical tomographic systems for acquiring and displaying dynamic data representing changes in a target tissue sample to external provocation. For example, the disclosed devices, methods and systems may be used for quantifying dynamic vascular changes caused by imposed blood pressure changes for diagnosing peripheral artery disease.

Abstract: Systems, methods, and devices for image reconstruction using combined PDE-constrained and simplified spherical harmonics (SPN) algorithm are presented herein. SPN equations can be used as the forward model in diffuse optical tomography (DOT) and employed in a PDE-constrained reduced space sequential quadratic programming (rSQP) optimization method to reconstruct spatially distributed optical properties, such as absorption, scattering, fat, oxygenated hemoglobin, de-oxygenated hemoglobin, fluorescent concentration, quantum yield, etc. The SPN algorithm with the PDE-constrained rSQP optimization method allows for DOT imaging that uses significantly less computational resources (e.g., time and random-access memory (RAM)) than methods employing the equation of radiative transfer (ERT). The techniques disclosed herein allow for more expeditious image processing as well as the potential for clinical diagnosis using DOT imaging.

Abstract: Devices, methods, and systems for providing optical imaging to detect and characterize anatomical and/or physiological indicators, such as, rheumatoid arthritis, and devices, methods and systems for computer aided detection and diagnosis of tomographic images. Embodiments for optimizing machine classification of tissue samples are described. Embodiments for using machine classification techniques to classify indicators present in optical tomographic images are described.

Abstract: Systems, methods, and devices for image reconstruction using combined PDE-constrained and simplified spherical harmonics (SPN) algorithm are presented herein. SPN equations can be used as the forward model in diffuse optical tomography (DOT) and employed in a PDE-constrained reduced space sequential quadratic programming (rSQP) optimization method to reconstruct spatially distributed optical properties, such as absorption, scattering, fat, oxygenated hemoglobin, de-oxygenated hemoglobin, fluorescent concentration, quantum yield, etc. The SPN algorithm with the PDE-constrained rSQP optimization method allows for DOT imaging that uses significantly less computational resources (e.g., time and random-access memory (RAM)) than methods employing the equation of radiative transfer (ERT). The techniques disclosed herein allow for more expeditious image processing as well as the potential for clinical diagnosis using DOT imaging.

Abstract: A methods for imaging tissue using diffuse optical tomography with digital detection includes directing at the tissue a plurality of amplitude modulated optical signals from a plurality of optical signal sources illuminating the tissue at a plurality of locations; detecting a resulting plurality of attenuated optical signals exiting the tissue to obtain a plurality of analog signals containing diffuse optical tomographic information; converting the analog signals into digital signals; recovering the tomographic information from the digital signals using a digital signal processor-based detection module that performs digital detection, wherein the detection module includes a master digital signal processing subsystem and at least one slave digital signal processing subsystem that processes at least a portion of the digital signals and the master digital signal processing subsystem controls the at least one slave digital signal processing subsystem; and transmitting the recovered tomographic information in digi

Abstract: Joint imaging devices methods and systems provide multiple sources and detectors around small accessible joints, such as fingers, to permit optical tomographic image acquisition and diagnosis of medical conditions such as rheumatoid arthritis. In embodiments, transducers permit convenient arrangement of sources and detectors and the rapid acquisition of anatomical surface geometry.