Patents by Inventor Andreas Haupt

Andreas Haupt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
    Patent number: 5965537
    Abstract: The present invention relates to novel peptides useful as anti-cancer agents. The compounds of the invention are of Formula I,A-B-D-E-F-G (I)A, B, D, and E are .alpha.-amino acid residues. In one embodiment, F is an azacycloalkanecarboxylic acid residue. In this embodiment, G is a monovalent radical, for example, a hydrogen atom, an alkyl group, an aryl group, or a heteroaryl group. In another embodiment, F is an azacycloalkyl group and G is a heteroaryl group connected to F by a carbon-carbon bond.In another embodiment, the invention includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.
    Type: Grant
    Filed: March 10, 1997
    Date of Patent: October 12, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Kurt Ritter, Wilhelm Amberg, Teresa Barlozzari, Andreas Haupt, Bernd Janssen, Andreas Kling
  • Preparation of active peptides
    Patent number: 5965700
    Abstract: A process for preparing pentapeptides of the formula I ##STR1## where A and R.sup.1 -R.sup.3 have the stated meanings, comprises assembling the pentapeptide stepwise starting from a prolinamide of the formula II ##STR2## where R.sup.1 and R.sup.2 have the abovementioned meanings, and eliminating the group --NR.sup.1 R.sup.2 by hydrolysis where appropriate the peptide obtained in this way.
    Type: Grant
    Filed: January 13, 1998
    Date of Patent: October 12, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Wilhelm Amberg, Harald Bernard, Ernst Buschmann, Andreas Haupt, Bernd Janssen, Ulrich Karl, Andreas Kling, Stefan Muller, Kurt Ritter, Thomas Zierke
  • Tetrapeptides as antitumor agents
    Patent number: 5939527
    Abstract: The present invention provides anti-tumor peptides of Formula I,A--B--NR.sup.3 --CHD--CH(OCH.sub.3)--CH.sub.2 CO--E--K (I),and the acid salts thereof. A is an amino acid residue selected from the group consisting of N-methyl-D-prolyl, N-methyl-D-homoprolyl and N,N-dimethyl-2-ethylphenylglycyl, or an amino acid residue of the formula R.sup.1 R.sup.2 N--CHX--CO, wherein R.sup.1 is a-methyl group or an ethyl group, R.sup.2 is a hydrogen atom, a methyl group or an ethyl group, and X is an alkyl group. B is an amino acid residue selected from the group consisting of valyl, isoleucyl, leucyl, and 2-t-butylglycyl. R.sup.3 is a hydrogen atom or a methyl group. D is a normal or branched C.sub.2 -C.sub.5 -alkyl group. E is an amino acid residue selected from the group consisting of prolyl, homoprolyl, 5-methylprolyl, and phenylalanyl, or E is a residue derived from an amino acid comprising a pyrrolidine group. K is an alkoxy group or an amino group.
    Type: Grant
    Filed: July 30, 1996
    Date of Patent: August 17, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Teresa Barlozzari, Andreas Haupt, Bernd Janssen, Christian Griesinger, Daniel Belik, Michael Boretzky
  • Compounds useful for the synthesis of dolastatin analogs
    Patent number: 5886147
    Abstract: Compounds of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.
    Type: Grant
    Filed: November 6, 1996
    Date of Patent: March 23, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Wilhelm Amberg, Harald Bernard, Ernst Buschmann, Andreas Haupt, Lothar Janitschke, Bernd Janssen, Ulrich Karl, Andreas Kling, Stefan Muller, Bernd de Potzolli, Kurt Ritter, Marco Thyes, Thomas Zierke
  • Active peptide and its preparation
    Patent number: 5864012
    Abstract: The compound Me.sub.2 Val--Val--MeVal--Pro--Pro--NHBzl.multidot.HCl is described. It is prepared from Z--Val--Val--MeVal--Pro--OR.sup.1 where Z and R.sup.1 have the meanings stated in the description. The compound shows antineoplastic activity.
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: January 26, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Wilhelm Amberg, Harald Bernard, Ernst Buschmann, Andreas Haupt, Lothar Janitschke, Bernd Janssen, Ulrich Karl, Andreas Kling, Stefan Muller, Bernd de Potzolli, Kurt Ritter, Marco Thyes, Thomas Zierke
  • Antitumor peptides
    Patent number: 5831002
    Abstract: Novel compounds of the formulaR.sup.1 R.sup.2 N--CHX-CO-A-B-D-(E).sub.s -(F).sub.t -(G).sub.U -KIin which R.sup.1, R.sup.2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 3, 1998
    Assignee: BASF Aktiengesellschaft
    Inventors: Andreas Haupt, Franz Emling, Cynthia Romerdahl
  • Oligopeptides, the preparation and use thereof
    Patent number: 5807984
    Abstract: Novel peptides of the formulaA--B--D--E--F--L,wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.
    Type: Grant
    Filed: November 9, 1995
    Date of Patent: September 15, 1998
    Assignee: BASF Aktienegesellschaft
    Inventors: Andreas Kling, Bernd Janssen, Wilhelm Amberg, Andreas Haupt, Kurt Ritter, Ernst Buschmann, Harald Bernard, Stefan Muller, Thomas Zierke, Teresa Barlozzari, Monika de Arruda, Simon Robinson
  • Pentapeptides as antitumor agents
    Patent number: 5741892
    Abstract: The present invention provides anti-tumor peptides of Formula I,A-B-N (CH.sub.3)-CHD-CH(OCH.sub.3)-CH.sub.2 CO-Pro-Pro-K (I),and the acid salts thereof. A is an amino acid residue of the formula (CH.sub.3).sub.2 N--CHX--CO, wherein X is a normal or branched alkyl group. B is an amino acid residue selected from the group consisting of valyl, isoleucyl, leucyl, and 2-t-butylglycyl. D is a normal or branched C.sub.3 -C.sub.4 -alkyl group. K is a t-butoxy group or a substituted amino group.An additional embodiment of the present invention is a method for treating a malignancy in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound or compounds of Formula I in a pharmaceutically acceptable composition.
    Type: Grant
    Filed: July 30, 1996
    Date of Patent: April 21, 1998
    Assignee: Basf Aktiengesellschaft
    Inventors: Teresa Barlozzari, Andreas Haupt, Bernd Janssen, Christian Griesinger, Daniel Belik, Michael Boretzky, George R. Pettit
  • Peptides, their preparation and use
    Patent number: 5504189
    Abstract: Antitumor peptides of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meanings stated in the description, and the preparation thereof.
    Type: Grant
    Filed: December 16, 1993
    Date of Patent: April 2, 1996
    Assignee: BASF Aktiengesellschaft
    Inventors: Franz Emling, Andreas Haupt, Michael Kluge, Matthias Kroner, Gerhard Haas, Ulrich Schmidt, Helmut Griesser, Bernd Riedl
  • Peptides, the preparation and use thereof
    Patent number: 5502032
    Abstract: Novel peptides of the formula ##STR1## in which R.sup.1, R.sup.2, X, A, R.sup.3, B, D, E, R.sup.7, M, Q, a, b and d have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
    Type: Grant
    Filed: January 5, 1994
    Date of Patent: March 26, 1996
    Assignee: BASF Aktiengesellschaft
    Inventors: Andreas Haupt, Bernd Janssen, Kurt Ritter, Dagmar Klinge, Gerhard Keilhauer, Cynthia Romerdahl, Teresa Barlozzari, Xiao-dong Qian