Patents by Inventor Andreas Heinze
Andreas Heinze has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11661595Abstract: Disclosed is a device for applying an electric field to a suspension of cells, comprising at least one chamber which comprises at least one internal space (40) for holding the suspension, the internal space (40) comprising at least two segments (41, 42), wherein each segment (41, 42) comprises at least one electrode (43, 44) and wherein neighboring electrodes (43, 44) are separated from each other by at least one gap (47) which is at least partially filled with an insulating material (46), and wherein the edges of the electrodes (43, 44) facing each other within the internal space (40) are rounded. Rounding the electrodes' edges facing a neighboring electrode results in a significant reduction of field gradients and thus even of the risk of arcing. Also disclosed is a method in which voltage is applied to at least one active electrode (43, 44) while the electrodes (43, 44, 45) or electrode segments next and/or opposite to the active electrode (43, 44) are set to ground potential.Type: GrantFiled: March 17, 2020Date of Patent: May 30, 2023Assignee: Lonza Cologne GmbHInventors: Ludger Altrogge, Timo Gleissner, Andreas Heinze, Sven Hermsmeier
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Patent number: 11352615Abstract: The invention relates to a device (1) for applying an electric field to a suspension of cells, cell derivatives, organelles, sub-cellular particles and/or vesicles, comprising at least one chamber (6) which comprises at least two electrodes (4), and at least one separating element (13) which is movable within the chamber (6) between two terminal points (14, 15) and, if it is in a position between the terminal points (14, 15), separates at least one first compartment (26) of the chamber (6) from at least one second compartment (27) of the chamber (6).Type: GrantFiled: November 9, 2018Date of Patent: June 7, 2022Assignee: Lonza Cologne GmbHInventors: Ludger Altrogge, Timo Gleissner, Andreas Heinze, Sven Hermsmeier
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Publication number: 20210324367Abstract: Disclosed is a method for subjecting adherent cells to at least one electric field, in which the electric field is generated by applying a voltage to at least two active electrodes 63, wherein at least three electrodes 63, 64 are provided, and wherein at least two electrodes 63, 64 are active electrodes 63 when the voltage is applied in order to generate a first electric field, and in which at least one second electric field is generated, wherein at least one of the two previously active electrodes 63 is a potential-free electrode 64 when the voltage is applied. Also disclosed is a device 58 comprising at least three electrodes 63, 64, which are connected to at least one voltage source by means of at least one switching device 59, 60, 61, 62, wherein at least five electrodes 63, 64 are connected to the at least one voltage source by means of four switching devices 59, 60, 61, 62, wherein at least two electrodes 63, 64 are connected to the voltage source by means of a common switching device 59, 60, 61, 62.Type: ApplicationFiled: May 5, 2021Publication date: October 21, 2021Applicant: Lonza Cologne GmbHInventors: Thomas Koblizek, Andreas HEINZE, Timo GLEISSNER, Herbert Mueller-Hartmann, Andreas WIRTH
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Patent number: 11021698Abstract: Disclosed is a method for subjecting adherent cells to at least one electric field, in which the electric field is generated by applying a voltage to at least two active electrodes 63, wherein at least three electrodes 63, 64 are provided, and wherein at least two electrodes 63, 64 are active electrodes 63 when the voltage is applied in order to generate a first electric field, and in which at least one second electric field is generated, wherein at least one of the two previously active electrodes 63 is a potential-free electrode 64 when the voltage is applied. Also disclosed is a device 58 comprising at least three electrodes 63, 64, which are connected to at least one voltage source by means of at least one switching device 59, 60, 61, 62, wherein at least five electrodes 63, 64 are connected to the at least one voltage source by means of four switching devices 59, 60, 61, 62, wherein at least two electrodes 63, 64 are connected to the voltage source by means of a common switching device 59, 60, 61, 62.Type: GrantFiled: May 11, 2017Date of Patent: June 1, 2021Assignee: LONZA COLOGNE GMBHInventors: Thomas Koblizek, Andreas Heinze, Timo Gleissner, Herbert Mueller-Hartmann, Andreas Wirth
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Publication number: 20200325466Abstract: Disclosed is a device for applying an electric field to a suspension of cells, comprising at least one chamber which comprises at least one internal space (40) for holding the suspension, the internal space (40) comprising at least two segments (41, 42), wherein each segment (41, 42) comprises at least one electrode (43, 44) and wherein neighboring electrodes (43, 44) are separated from each other by at least one gap (47) which is at least partially filled with an insulating material (46), and wherein the edges of the electrodes (43, 44) facing each other within the internal space (40) are rounded. Rounding the electrodes' edges facing a neighboring electrode results in a significant reduction of field gradients and thus even of the risk of arcing. Also disclosed is a method in which voltage is applied to at least one active electrode (43, 44) while the electrodes (43, 44, 45) or electrode segments next and/or opposite to the active electrode (43, 44) are set to ground potential.Type: ApplicationFiled: March 17, 2020Publication date: October 15, 2020Applicant: Lonza Cologne GmbHInventors: Ludger ALTROGGE, Timo GLEISSNER, Andreas HEINZE, Sven HERMSMEIER
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Patent number: 10633646Abstract: The invention relates to a device for applying an electric field to a suspension of cells, comprising at least one chamber which comprises at least one internal space (40) for holding the suspension, the internal space (40) comprising at least two segments (41, 42), wherein each segment (41, 42) comprises at least one electrode (43, 44) and wherein neighboring electrodes (43, 44) are separated from each other by at least one gap (47) which is at least partially filled with an insulating material (46), and wherein the edges of the electrodes (43, 44) facing each other within the internal space (40) are rounded. Rounding the electrodes' edges facing a neighboring electrode results in a significant reduction of field gradients and thus even of the risk of arcing. The invention further concerns a method, wherein voltage is applied to at least one active electrode (43, 44) while the electrodes (43, 44, 45) or electrode segments next and/or opposite to the active electrode (43, 44) are set to ground potential.Type: GrantFiled: April 28, 2015Date of Patent: April 28, 2020Assignee: LONZA COLOGNE GMBHInventors: Ludger Altrogge, Timo Gleissner, Andreas Heinze, Sven Hermsmeier
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Publication number: 20190390344Abstract: The present invention relates to a process module comprising at least one evacuable process chamber located in the process module and at least one support device being horizontally moveable through the process module in at least one substrate transport direction for accommodating respectively at least one flat substrate which is to be processed in the process chamber. It is the object of the present invention to provide a process module of the above-mentioned type, which allows a consistent and high-quality processing of all substrates at high production speed and at the lowest device costs possible. Said object is solved by a process module of the above mentioned type in which the at least one process chamber is physically closeable with respect to the process module by means of the support device, the position of which is changeable in at least one closing direction transverse to the substrate transport direction, wherein the at least one support device forms a bottom of the at least one process chamber.Type: ApplicationFiled: June 5, 2019Publication date: December 26, 2019Inventors: JOACHIM MAI, DANNY MUELLER, SEBASTIAN RASCHKE, ANDREAS HEINZE
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Patent number: 10336996Abstract: The invention relates to a device (1) for applying an electric field to a suspension of cells, cell derivatives, organelles, sub-cellular particles and/or vesicles, comprising at least one chamber (6) which comprises at least two electrodes (4), and at least one separating element (13) which is movable within the chamber (6) between two terminal points (14, 15) and, if it is in a position between the terminal points (14, 15), separates at least one first compartment (26) of the chamber (6) from at least one second compartment (27) of the chamber (6).Type: GrantFiled: April 28, 2015Date of Patent: July 2, 2019Assignee: LONZA COLOGNE GMBHInventors: Ludger Altrogge, Timo Gleissner, Andreas Heinze, Sven Hermsmeier
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Publication number: 20190144844Abstract: The invention relates to a device (1) for applying an electric field to a suspension of cells, cell derivatives, organelles, sub-cellular particles and/or vesicles, comprising at least one chamber (6) which comprises at least two electrodes (4), and at least one separating element (13) which is movable within the chamber (6) between two terminal points (14, 15) and, if it is in a position between the terminal points (14, 15), separates at least one first compartment (26) of the chamber (6) from at least one second compartment (27) of the chamber (6).Type: ApplicationFiled: November 9, 2018Publication date: May 16, 2019Applicant: Lonza Cologne GmbHInventors: Ludger ALTROGGE, Timo GLEISSNER, Andreas HEINZE, Sven HERMSMEIER
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Publication number: 20190001330Abstract: The present invention is directed to methods, compositions and devices useful for the detection and/or quantification of a microbial contaminant, including an endotoxin. In embodiments, cartridges are provided that include dried compositions that are useful in absorbance-based assays and in combination with portable readers/devices.Type: ApplicationFiled: June 27, 2018Publication date: January 3, 2019Inventors: Gerald SANDO, Candice STUMBAUGH, Cindy HUNT, Andreas HEINZE, Andy DURNAN, Paul LEWIS, James BAKER, Will HARRIS
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Publication number: 20170306317Abstract: Disclosed is a method for subjecting adherent cells to at least one electric field, in which the electric field is generated by applying a voltage to at least two active electrodes 63, wherein at least three electrodes 63, 64 are provided, and wherein at least two electrodes 63, 64 are active electrodes 63 when the voltage is applied in order to generate a first electric field, and in which at least one second electric field is generated, wherein at least one of the two previously active electrodes 63 is a potential-free electrode 64 when the voltage is applied. Also disclosed is a device 58 comprising at least three electrodes 63, 64, which are connected to at least one voltage source by means of at least one switching device 59, 60, 61, 62, wherein at least five electrodes 63, 64 are connected to the at least one voltage source by means of four switching devices 59, 60, 61, 62, wherein at least two electrodes 63, 64 are connected to the voltage source by means of a common switching device 59, 60, 61, 62.Type: ApplicationFiled: May 11, 2017Publication date: October 26, 2017Inventors: Thomas Koblizek, Andreas Heinze, Timo Gleissner, Herbert Mueller-Hartmann, Andreas WIRTH
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Publication number: 20170233715Abstract: The invention relates to a device (1) for applying an electric field to a suspension of cells, cell derivatives, organelles, sub-cellular particles and/or vesicles, comprising at least one chamber (6) which comprises at least two electrodes (4), and at least one separating element (13) which is movable within the chamber (6) between two terminal points (14, 15) and, if it is in a position between the terminal points (14, 15), separates at least one first compartment (26) of the chamber (6) from at least one second compartment (27) of the chamber (6).Type: ApplicationFiled: April 28, 2015Publication date: August 17, 2017Inventors: Ludger Altrogge, Timo Gleissner, Andreas Heinze, Sven Hermsmeier
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Publication number: 20170233716Abstract: The invention relates to a device for applying an electric field to a suspension of cells, comprising at least one chamber which comprises at least one internal space (40) for holding the suspension, the internal space (40) comprising at least two segments (41, 42), wherein each segment (41, 42) comprises at least one electrode (43, 44) and wherein neighboring electrodes (43, 44) are separated from each other by at least one gap (47) which is at least partially filled with an insulating material (46), and wherein the edges of the electrodes (43, 44) facing each other within the internal space (40) are rounded. Rounding the electrodes' edges facing a neighboring electrode results in a significant reduction of field gradients and thus even of the risk of arcing. The invention further concerns a method, wherein voltage is applied to at least one active electrode (43, 44) while the electrodes (43, 44, 45) or electrode segments next and/or opposite to the active electrode (43, 44) are set to ground potential.Type: ApplicationFiled: April 28, 2015Publication date: August 17, 2017Inventors: Ludger Altrogge, Timo Gleissner, Andreas Heinze, Sven Hermsmeier
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Patent number: 9701954Abstract: The invention relates to a method for subjecting adherent cells to at least one electric field, in which the electric field is generated by applying a voltage to at least two active electrodes 63, wherein at least three electrodes 63, 64 are provided, and wherein at least two electrodes 63, 64 are active electrodes 63 when the voltage is applied in order to generate a first electric field, and in which at least one second electric field is generated, wherein at least one of the two previously active electrodes 63 is a potential-free electrode 64 when the voltage is applied.Type: GrantFiled: June 21, 2011Date of Patent: July 11, 2017Assignee: LONZA COLOGNE GMBHInventors: Thomas Koblizek, Andreas Heinze, Timo Gleissner, Herbert Mueller-Hartmann, Andreas Wirth
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Patent number: 9284525Abstract: The invention relates to a method for the application of at least one voltage pulse to at least two containers fitted with electrodes, by means of which at least one voltage pulse is applied to at least one container, while at least one other container is subjected to a preparation or a post-processing. According to the invention the method comprises mutual exchange of the respective positions of the container to which a voltage pulse has already been applied and the further container. Furthermore, the invention relates to a device (1) for making electrical contact with at least one container fitted with electrodes, with at least one receptacle (3, 7) upon which at least one container can be set, and with at least one contact appliance (8) for making contact with the electrodes of the container.Type: GrantFiled: January 20, 2010Date of Patent: March 15, 2016Assignee: LONZA COLOGNE GMBHInventors: Ludger Altrogge, Timo Gleissner, Andreas Heinze, Herbert Müller-Hartmann, Andreas Wirth
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Patent number: 9249384Abstract: The invention relates to a method for applying at least one electrical voltage pulse to at least one reaction space by at least partially discharging at least one charge storing unit for storing electrical charges. According to the invention the method comprises applying at least one voltage pulse to a reaction space by at least partially discharging a second charge storing unit and simultaneously charging or partially discharging a first charge storing. Furthermore, the invention relates to a device 1 for applying at least one electrical voltage pulse to at least one reaction space, comprising at least two charge storing units (10, 11) for storing electrical charges and at least one power supply unit (12) for charging the charge storing units (10, 11) and/or at least one discharge device for partially discharging the charge storing units (10, 11). According to the invention it is provided that at least two of the charge storing units (10, 11) form a common storage module which can be discharged at any time.Type: GrantFiled: January 20, 2010Date of Patent: February 2, 2016Assignee: LONZA COLOGNE GMBHInventors: Ludger Altrogge, Timo Gleissner, Andreas Heinze, Herbert Müller-Hartmann, Andreas Wirth
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Patent number: 9080139Abstract: The invention relates to a container (1) with at least three reaction spaces (2) which in each case have at least one electrode pair for applying an electric voltage for generating an electric field within the reaction space (2) and which are arranged geometrically in at least one row and/or electrically connected in at least one row, wherein at least one electrode (3, 4) of a reaction space (2) is a common electrode (3, 4) with at least one other reaction space (2). According to the invention n+x electrodes (3, 4, 5) are provided, wherein n is the number of reaction spaces (2), with n?3 and x is the number of rows, with x?1.Type: GrantFiled: January 20, 2010Date of Patent: July 14, 2015Assignee: LONZA COLOGNE GMBHInventors: Ludger Altrogge, Timo Gleissner, Andreas Heinze, Herbert Mueller-Hartmann, Andreas Wirth
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Publication number: 20150152555Abstract: A process module includes at least one evacuable process chamber in the process module and at least one support device horizontally moveable through the process module in at least one substrate transport direction for respectively accommodating at least one flat substrate to be processed in the process chamber. The process module allows consistent and high-quality processing of all substrates at high production speed and at the lowest device costs possible. In the process module the at least one process chamber is physically closeable with respect to the process module by the support device, the position of which is changeable in at least one closing direction transverse to the substrate transport direction and the at least one support device forms a bottom of the at least one process chamber.Type: ApplicationFiled: January 17, 2013Publication date: June 4, 2015Inventors: Joachim Mai, Danny Mueller, Sebastian Raschke, Andreas Heinze
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Publication number: 20130230895Abstract: The invention relates to a method for subjecting adherent cells to at least one electric field, in which the electric field is generated by applying a voltage to at least two active electrodes 63, wherein at least three electrodes 63, 64 are provided, and wherein at least two electrodes 63, 64 are active electrodes 63 when the voltage is applied in order to generate a first electric field, and in which at least one second electric field is generated, wherein at least one of the two previously active electrodes 63 is a potential-free electrode 64 when the voltage is applied.Type: ApplicationFiled: June 21, 2011Publication date: September 5, 2013Applicant: LONZA COLOGNE GMBHInventors: Thomas Koblizek, Andreas Heinze, Timo Gleissner, Herbert Mueller-Hartmann, Andreas Wirth
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Publication number: 20120087841Abstract: The invention relates to a container (1) with at least three reaction spaces (2) which in each case have at least one electrode pair for applying an electric voltage for generating an electric field within the reaction space (2) and which are arranged geometrically in at least one row and/or electrically connected in at least one row, wherein at least one electrode (3, 4) of a reaction space (2) is a common electrode (3, 4) with at least one other reaction space (2). According to the invention n+x electrodes (3, 4, 5) are provided, wherein n is the number of reaction spaces (2), with n?3 and x is the number of rows, with x?1.Type: ApplicationFiled: January 20, 2010Publication date: April 12, 2012Applicant: LONZA COLOGNE GMBHInventors: Ludger Altrogge, Timo Gleissner, Andreas Heinze, Herbert Mueller-Hartmann, Andreas Wirth