Patents by Inventor Andreas K. Nussler

Andreas K. Nussler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inducible nitric oxide synthase for treatment of disease
    Publication number: 20020061862
    Abstract: The invention provides a pharmaceutical composition comprising as an active ingredient a pharmaceutical agent comprising a DNA sequence that codes for a protein which possesses the biological activity of inducible nitrogen monoxide synthase (iNOS) and eukaryotic regulation elements, wherein the eukaryotic regulation elements result in the expression of said DNA sequence in eukaryotic cells, and a pharmaceutically acceptable carrier. The pharmaceutical agent can be complexed to liposomes.
    Type: Application
    Filed: November 13, 2001
    Publication date: May 23, 2002
    Applicant: University of Pittsburgh of the Commonwealth System of Higher Education
    Inventors: Timothy R. Billiar, Edith Tzeng, David Geller, Richard L. Simmons, Larry L. Shears, Andreas K. Nussler
  • Isolated human inducible nitric oxide synthase
    Patent number: 5882908
    Abstract: A human tissue inducible nitric oxide synthase cDNA clone is disclosed. A process for preparing this cDNA clone coding for human tissue inducible nitric oxide synthase and for expressing the human tissue inducible nitric oxide synthase protein are provided.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 16, 1999
    Assignee: University of Pittsburgh of the Commonwealth System of Higher Education
    Inventors: Timothy R.. Billiar, Andreas K. Nussler, David A. Geller, Richard L. Simmons
  • Inducible nitric oxide synthase gene for treatment of disease
    Patent number: 5658565
    Abstract: The present invention discloses a full-length human hepatocyte iNOS cDNA clone and various gene therapy applications utilizing an iNOS DNA sequence. In preferred embodiments of the disclosed invention, iNOS-directed gene therapy involves specific targeting of a DNA sequence encoding a protein or protein fragment with iNOS biological activity for treating vascular diseases and disorders, antitumor applications and in response to certain microbial infections.
    Type: Grant
    Filed: June 24, 1994
    Date of Patent: August 19, 1997
    Assignee: University of Pittsburgh of the Commonwealth System of Higher Education
    Inventors: Timothy R. Billiar, Edith Tzeng, Andreas K. Nussler, David A. Geller, Richard L. Simmons
  • cDNA clone for human inducible nitric oxide synthase and process for preparing same
    Patent number: 5468630
    Abstract: A human tissue inducible nitric oxide synthase cDNA clone is disclosed. A process for preparing this cDNA clone coding for human tissue inducible nitric oxide synthase and for expressing the human tissue inducible nitric oxide synthase protein are provided.
    Type: Grant
    Filed: September 28, 1994
    Date of Patent: November 21, 1995
    Assignee: University of Pittsburg of the Commonwealth System of Higher Education
    Inventors: Timothy R. Billiar, Andreas K. Nussler, David A. Geller, Richard L. Simmons