Abstract: The present invention relates to a method for transfection of cells using at least one protein capable of forming nucleoprotein filaments, wherein the protein is initially modified with at least one functional component which influences one or more steps of the transfection, the nucleic acid to be transfected is then loaded with the modified protein, whereby the nucleic acid and the protein form a filament-like complex, and this complex is finally added to the cells to be transfected. The invention further relates to a transfection agent consisting of nucleoprotein filaments (NPF), with at least one nucleoprotein filament-forming protein being modified with at least one functional component for the transfection. Furthermore, the present invention relates to the use of the transfection agent according to the invention for producing a drug for gene therapeutic treatment of humans and animals.

Abstract: Systems and methods for monitoring a network. Proxy loghosts, each one collecting log files that are generated by resources in a portion of a secure network, generate events in response to the log files collected. A central loghost in communication with the proxy loghosts receives the events from the proxy loghosts, analyzes the events, and determines the necessity of generating an alert and an associated alarm to notify a security manager of a possible intrusion incident, or other anomaly, in the network.