Patents by Inventor Andreas Kordikowski
Andreas Kordikowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120058160Abstract: Embodiments of the invention relate to particles of active substances, methods for preparing the particles, formulations containing the particles, and metered dose inhalers containing such particles or formulations. In one embodiment, a composition of an aerosol formulation is provided and contains a particulate active substance of non-micronized, solid particles having a mass median aerodynamic diameter of less than 10 ?m suspended in a hydrofluorocarbon fluid vehicle at a concentration within a range from about 0.2% w/v to about 5% w/v. The aerosol formulation exhibits a flocculation volume of about 85% or greater about 1 minute after mixing the particulate active substance and the hydrofluorocarbon fluid vehicle. The particulate active substance contains an alkaloid ergotamine, pharmaceutically acceptable salts thereof, analogues thereof, or derivatives thereof.Type: ApplicationFiled: November 11, 2011Publication date: March 8, 2012Inventors: Andreas Kordikowski, Stephen Ernest Walker, Peter York
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Patent number: 8080236Abstract: Embodiments of the invention relate to particles of active substances, methods for preparing the particles, formulations containing the particles, and metered dose inhalers containing the particles or formulations. In one embodiment, an inhaler contains an aerosol formulation containing a particulate active substance of non-micronized, solid particles having a mass median aerodynamic diameter of less than 10 ?m. The particles may be suspended in a nonsolvent hydrofluorocarbon fluid vehicle (e.g., HFA 134a or 227ea) at a concentration within a range from about 0.2% w/v to about 5% w/v. The formulation exhibits a flocculation volume of about 85% or greater about 1 minute after mixing the particulate active substance and the vehicle. The particulate active substance may contain salmeterol xinafoate, budesonide, salbutamol sulfate, dihydroergotamine mesylate, risperidone-(9-hydroxy)-palmitate, bromocriptine mesylate, or derivatives thereof. In some examples, the active substance is dihydroergotamine mesylate.Type: GrantFiled: June 12, 2009Date of Patent: December 20, 2011Assignee: Nektar Therapeutics UK, LtdInventors: Andreas Kordikowski, Stephen Ernest Walker, Peter York
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Publication number: 20090291050Abstract: Embodiments of the invention relate to particles of active substances, methods for preparing the particles, formulations containing the particles, and metered dose inhalers containing the particles or formulations. In one embodiment, an inhaler contains an aerosol formulation containing a particulate active substance of non-micronized, solid particles having a mass median aerodynamic diameter of less than 10 ?m. The particles may be suspended in a nonsolvent hydrofluorocarbon fluid vehicle (e.g., HFA 134a or 227ea) at a concentration within a range from about 0.2% w/v to about 5% w/v. The formulation exhibits a flocculation volume of about 85% or greater about 1 minute after mixing the particulate active substance and the vehicle. The particulate active substance may contain salmeterol xinafoate, budesonide, salbutamol sulfate, dihydroergotamine mesylate, risperidone-(9-hydroxy)-palmitate, bromocriptine mesylate, or derivatives thereof. In some examples, the active substance is dihydroergotamine mesylate.Type: ApplicationFiled: June 12, 2009Publication date: November 26, 2009Inventors: Andreas Kordikowski, Stephen Ernest Walker, Peter York
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Patent number: 7582284Abstract: The present invention relates to active substances in particulate form, to methods for preparing them, to formulations containing them and to uses of such substances and formulations. A preferred embodiment is directed to particulate suspensions having improved flocculation behavior in a suspension vehicle, such as a hydrofluoroalkane propellant used in metered dose inhalers.Type: GrantFiled: April 14, 2003Date of Patent: September 1, 2009Assignee: Nektar TherapeuticsInventors: Andreas Kordikowski, Stephen Ernest Walker, Peter York
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Publication number: 20060280823Abstract: Method for preparing a target substance in particulate form, comprising introducing into a particle formation vessel, through separate first and second fluid inlets respectively, (a) a “target solution/suspension” of the substance in a fluid vehicle and (b) a compressed fluid anti-solvent, and allowing the anti-solvent to extract the vehicle so as to form particles of the substance, wherein the anti-solvent fluid has a sonic, near-sonic or supersonic velocity as it enters the vessel, and wherein the anti-solvent and the target solution/suspension enter the vessel at different locations and meet downstream (in the direction of anti-solvent flow) of the second fluid inlet. Also provided is apparatus for use in such a method.Type: ApplicationFiled: May 3, 2006Publication date: December 14, 2006Inventors: Srinivas Palakodaty, Andreas Kordikowski, Darren Gilbert
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Publication number: 20060279011Abstract: Method for preparing a target substance in particulate form, comprising introducing into a particle formation vessel, through separate first and second fluid inlets respectively, (a) a “target solution/suspension” of the substance in a fluid vehicle and (b) a compressed fluid anti-solvent, and allowing the anti-solvent to extract the vehicle so as to form particles of the substance, wherein the anti-solvent fluid has a sonic, near-sonic or supersonic velocity as it enters the vessel, and wherein the anti-solvent and the target solution/suspension enter the vessel at different locations and meet downstream (in the direction of anti-solvent flow) of the second fluid inlet. Also provided is apparatus for use in such a method.Type: ApplicationFiled: May 3, 2006Publication date: December 14, 2006Inventors: Srinivas Palakodaty, Andreas Kordikowski, Darren Gilbert
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Patent number: 7087197Abstract: Method for preparing a target substance in particulate form, comprising introducing into a particle formation vessel, through separate first and second fluid inlets respectively, (a) a “target solution/suspension” of the substance in a fluid vehicle and (b) a compressed fluid anti-solvent, and allowing the anti-solvent to extract the vehicle so as to form particles of the substance, wherein the anti-solvent fluid has a sonic, near-sonic or supersonic velocity as it enters the vessel, and wherein the anti-solvent and the target solution/suspension enter the vessel at different locations and meet downstream (in the direction of anti-solvent flow) of the second fluid inlet. Also provided is apparatus for use in such a method.Type: GrantFiled: July 17, 2002Date of Patent: August 8, 2006Assignee: Nektar TherapeuticsInventors: Srinivas Palakodaty, Andreas Kordikowski, Darren Gilbert
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Publication number: 20060160871Abstract: One or more embodiments of the invention provide various novel formulations, and tablet dosage forms, comprising losartan that are non-crystalline, stable, and/or otherwise improvements over known losartan formulations. One or more embodiments of the invention further provide methods for preparing the formulation, methods for preparing the tablet dosage form, and to methods of administering the tablet dosage and/or formulation comprising losartan. The losartan-containing formulations may be administered to a user to treat hypertension, and related conditions.Type: ApplicationFiled: December 6, 2005Publication date: July 20, 2006Applicant: Nektar TherapeuticsInventors: Srinivas Palakodaty, Jiang Zhang, Andreas Kordikowski, Linda Daintree, Sarma Duddu, Alan Kugler, Herm Snyder, David Lechuga-Ballesteros, Nagesh Palepu, Michael Eldon
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Publication number: 20050085409Abstract: Method for preparing a target substance in particulate form, by introducing into a particle formation vessel, through separate first and second fluid inlets respectively, (a) a solution or suspension of the target substance in a fluid vehicle (the “target solution/suspension”) and (b) a compressed fluid anti-solvent for the substance, and allowing the anti-solvent to extract the vehicle from the target solution/suspension so as to form particles of the target substance, wherein the target solution/suspension enters the vessel downstream of the point of entry of the anti-solvent and at a point which lies on or close to the main axis of anti-solvent flow, and wherein the anti-solvent has a sub-sonic velocity as it enters the particle formation vessel.Type: ApplicationFiled: January 7, 2004Publication date: April 21, 2005Inventors: Andreas Kordikowski, Darren Gilbert
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Publication number: 20040028646Abstract: A polyalkylene glycol (PAG)—preferably a polyethylene glycol—or a derivative or conjugate thereof, in particulate form, having a residual solvent content of 200 ppm or less and a volume mean particle diameter of 25 &mgr;m or less. Also methods for forming particulate products containing PAGs or derivatives or conjugates thereof, in particular by carrying out a GAS process—preferably a Nektar™ SCF process—on a solution or suspension of a target substance but using as the anti-solvent fluid a compressed fluid which at the point of its contact with the solution or suspension is at a temperature of 25° C. or below.Type: ApplicationFiled: July 17, 2003Publication date: February 12, 2004Inventors: Remy Gross, Andreas Kordikowski, Raymond Sloan
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Publication number: 20030223939Abstract: The present invention relates to active substances in particulate form, to methods for preparing them, to formulations containing them and to uses of such substances and formulations. A preferred embodiment is directed to particulate suspensions having improved flocculation behaviour in a suspension vehicle, such as a hydrofluoroalkane propellant used in metered dose inhalers.Type: ApplicationFiled: April 14, 2003Publication date: December 4, 2003Inventors: Andreas Kordikowski, Stephen Ernest Walker, Peter York
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Publication number: 20030109421Abstract: Method for preparing a target substance in particulate form, comprising introducing into a particle formation vessel, through separate first and second fluid inlets respectively, (a) a “target solution/suspension” of the substance in a fluid vehicle and (b) a compressed fluid anti-solvent, and allowing the anti-solvent to extract the vehicle so as to form particles of the substance, wherein the anti-solvent fluid has a sonic, near-sonic or supersonic velocity as it enters the vessel, and wherein the anti-solvent and the target solution/suspension enter the vessel at different locations and meet downstream (in the direction of anti-solvent flow) of the second fluid inlet. Also provided is apparatus for use in such a method.Type: ApplicationFiled: July 17, 2002Publication date: June 12, 2003Inventors: Srinivas Palakodaty, Andreas Kordikowski, Darren Gilbert