Abstract: Systems and methods for adjusting operating parameters of at least one pipelined software asset. Within a pipelined environment, an agent software asset is inserted immediately preceding a software asset whose operating parameters are to be adjusted. The agent software asset receives data and/or data sets from a user and such data and data sets are inserted/used by the software asset. The agent software asset also allows for a reporting of the output of other software assets to thereby provide users with intermediate outputs from the pipelined environment.

Abstract: A gas metering valve for an internal combustion engine. The gas metering valve includes a housing in which a gas chamber is formed, which includes an inlet opening and an outlet opening. A movable valve element is situated in the gas chamber, which is movable by an electrical actuator against the force of a return spring and which cooperates with a valve seat for opening and closing the inlet opening. A blocking valve is situated between the valve element and the outlet opening, which opens in the flow direction to the outlet opening and blocks in the opposite flow direction.

Abstract: Systems and methods for adjusting operating parameters of at least one pipelined software asset. Within a pipelined environment, an agent software asset is inserted immediately preceding a software asset whose operating parameters are to be adjusted. The agent software asset receives data and/or data sets from a user and such data and data sets are inserted/used by the software asset. The agent software asset also allows for a reporting of the output of other software assets to thereby provide users with intermediate outputs from the pipelined environment.

Abstract: Systems and methods for managing software resources such as machine learning/artificial intelligence models. The system includes a number of components that provide versioning services to both software resources and to data sets. A data storage component also addresses storage/retrieval functions for the system. A user interface element is also present to provide users with both a GUI and a command line interface. An assessment element assesses user selected software assets for project inclusion, with the assessment being based on good software development principles and practices. Once a project of selected software assets has passed the assessment stage, the software assets are pipelined for execution by an execution unit. The outputs of the execution unit are sent to a data output module automatically populates predetermined and preconfigured templates with the outputs to produce reports. The outputs may be final outputs or they may be intermediate results produced by the software assets.

Abstract: A gas metering valve for an internal combustion engine. The gas metering valve includes a housing in which a gas chamber is formed, which includes an inlet opening and an outlet opening. A movable valve element is situated in the gas chamber, which is movable by an electrical actuator against the force of a return spring and which cooperates with a valve seat for opening and closing the inlet opening. A blocking valve is situated between the valve element and the outlet opening, which opens in the flow direction to the outlet opening and blocks in the opposite flow direction.

Abstract: A system operating in a plurality of modes to provide an integrated analysis of molecular data, imaging data, and clinical data associated with a patient includes a multi-scale model, a molecular model, and a linking component. The multi-scale model is configured to generate one or more estimated multi-scale parameters based on the clinical data and the imaging data when the system operates in a first mode, and generate a model of organ functionality based on one or more inferred multi-scale parameters when the system operates in a second mode. The molecular model is configured to generate one or more first molecular findings based on a molecular network analysis of the molecular data, wherein the molecular model is constrained by the estimated parameters when the system operates in the first mode.

Abstract: A system operating in a plurality of modes to provide an integrated analysis of molecular data, imaging data, and clinical data associated with a patient includes a multi-scale model, a molecular model, and a linking component. The multi-scale model is configured to generate one or more estimated multi-scale parameters based on the clinical data and the imaging data when the system operates in a first mode, and generate a model of organ functionality based on one or more inferred multi-scale parameters when the system operates in a second mode. The molecular model is configured to generate one or more first molecular findings based on a molecular network analysis of the molecular data, wherein the molecular model is constrained by the estimated parameters when the system operates in the first mode.

Abstract: The use of carbohydrate-based surfactant compounds having the general formula (I): wherein Y1 and Y2, which may be the same or different, are carbohydrate groups; R1 and R2, which may be the same or different, are selected from: a) hydrogen; b) C(1-24) alkyl group; c) C(1-24) alkyl carboxy group; or d) a carbon chain of 2 to 24 carbon atoms having one or more carbon/carbon double bonds, and n is from 1 to 10; for facilitating the transfer of DNA or RNA polynucleotides, or analogs thereof, into a eukaryotic or prokaryotic cell in vivo or in vitro. New carbohydrate-based surfactant compounds are also disclosed.

Abstract: Spermine:peptide-based surfactant compounds are disclosed. The compounds are based on a spermine backbone with peptide groups and optionally hydrocarbyl groups linked thereto. Uses of the spermine:peptide-based surfactant compounds and methods for their production are also disclosed.

Abstract: Spermine:peptide-based surfactant compounds are disclosed. The compounds are based on a spermine backbone with peptide groups and optionally hydrocarbyl groups linked thereto. Uses of the spermine:peptide-based surfactant compounds and methods for their production are also disclosed.

Abstract: New peptide-based gemini compounds comprising two linked chains: 1

Abstract: New peptide-based Gemini compounds comprising two linked chains (a) each having: (1) a positively charged hydrophilic head, Q1 or Q2 formed from one or more amino acids and/or amines, (2) a central portion, P1 or P2, having a polypeptide backbone, and (3) a hydrophobic tail, R1 or R2, the central sections of each chain being linked together by bridge Y through residues in P1 and P2, are disclosed. Methods for their preparation and uses are also disclosed. Such uses include transfection of polynucleotides into cells in vivo.

Abstract: The invention provides compositions and novel cDNAs that co-express with cell differentiation gene transcripts induced by retinoic acid. The invention also provides expression vectors, host cells, proteins encoded by the cDNAs and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis and treatment of and disorders associated with cell and tissue development and differentiation.