Abstract: A device for the simultaneous filling of microtiter plate wells via centrifugal forces. In an implementation, the device includes a planar attachment for a microtiter plate having one or more liquid reservoirs for filling one well each of the microtiter plate per liquid reservoir. Each liquid reservoir has an upper filling opening for receiving a filling liquid, one or more lower filling nozzles for dispensing the filling liquid into the well of the microtiter plate, and a reservoir wall which connects the filling opening and the filling nozzle to one another. The filling nozzle is arranged off-center to the axis of symmetry of the microtiter plate well and off-center to the axis of symmetry of the filling opening of the filling device in a subregion of the reservoir wall.

Abstract: The invention relates to a method for finding inhibitors of the peptidyl-prolyl cis-trans isomerase FKBP1A or antibodies, proteins or molecules having a specific affinity to FKBP1A. The invention also relates to FKBP1A-specific siRNA, inhibitors of the expression of FKBP1A, inhibitors of the enzymatic activity of FKBP1A, and inhibitors of the interaction(s) of FKBP1A with interaction partner(s), in each case for the treatment of diseases, in particular cancers or neurodegenerative diseases. The invention further relates to the use of FKBP1A as a prognostic or diagnostic marker for cancers. The cancers are preferably mammary carcinoma, in particular triple-negative mammary carcinoma, in this case very particularly the mesenchymal stem-like sub-type.

Abstract: The invention relates to new cancer treatment strategies based on the inhibition of acid lipase. In addition, the invention relates to methods for discovering new active substances suitable for cancer therapy.

Abstract: The present invention comprises a test for the identification of an agent, which induces (re-)differentiation in a tumour cell based on the novel combined application of the two markers lactate as the end-product of the katabolic anaerobic glycolysis and neutral lipids as the end-product of the anabolic neutral lipid synthesis. The cell-based system is further characterized by a novel liquid handling procedure, which allows valid high throughput screening even over a longer time period of at least seven days, and a new viability test.

Abstract: The invention relates to a circuit arrangement (1) comprising an electrical and/or electronic circuit unit (10), which comprises a circuit carrier (14), on which at least one electrical and/or electronic component (12) is arranged, and at least one connection region (5) with at least one contact unit (14.2) for electrically contact-connecting the electrical and/or electronic circuit unit (10) to other electrical and/or electronic structural units, wherein at least one region of the circuit unit (10) is arranged in a housing unit (20) sealed relative to the surroundings. According to the invention, the housing unit (20) comprises a protective compound which surrounds the at least one region of the circuit unit (10) in a sealing fashion and surrounds the at least one connection region (5) in such a way that the at least one contact unit (14.2) is embedded at least at its side areas into the protective compound (22).

Abstract: A circuit board cooler employs a closed fluid delivery system to transfer heat from electronic components to a cooling fluid. One or more channels embedded within the circuit board carry cooling fluid to the components where the fluid absorbs heat from the component, then away from the component to deposit the excess thermal energy in a thermal sink, such as a heat exchanger. The cooling system may employ conductive thermal transfer elements, such as “thermal vias”, to enhance heat transfer from electronic components to the cooling fluid.