Abstract: The present invention provides DNA polymerases and their use in various applications. The present invention also relates to uses and methods utilizing the DNA polymerase of the present invention for discriminating between matched and mismatched primers or detecting SNP or methylated cytosine. The present invention also relates to kits comprising such DNA polymerases.

Abstract: A vestibular electrode is described that is for implantation into a vestibular semi-circular canal. An intra-labyrinthine electrode carrier with a C-shaped cross-section has an inner concave surface and an outer convex surface, and is configured to fit through an electrode opening in an outer surface of the bony labyrinth into the perilymph fluid without breaking the membranous labyrinth so as to fit the inner concave surface of the electrode carrier adjacent to the membranous labyrinth and the outer convex surface adjacent to the bony labyrinth. There are one or more electrode contacts on a surface of the electrode carrier that are configured for electrical interaction with adjacent neural tissue.

Abstract: A brake system for a land vehicle includes at least one wheel brake; a pump configured to pump hydraulic fluid from the inlet side of the pump to the outlet side of the pump; at least one intermediate store for receiving hydraulic fluid; a hydraulic connection between the intermediate store and the inlet side of the pump; at least one first valve arrangement for blocking a hydraulic connection between the outlet side of the pump and the at least one wheel brake; at least one second valve arrangement for blocking a hydraulic connection between the at least one wheel brake and the inlet side of the pump; and at least one third valve arrangement for blocking a hydraulic connection between the outlet side of the pump and the intermediate store.

Abstract: The present invention relates to DNA polymerases displaying increased substrate scope such as improved reverse transcriptase and DNA polymerase activities, as well as improved activities for incorporating and extending modified nucleotides. In particular, the present invention relates to DNA polymerases derived from wild-type Thermus aquaticus (Taq) polymerase, comprising the mutations S515R, I638F, and M747K with regard to the wild-type amino acid sequence. The present invention further relates to nucleic acids coding for the DNA polymerases of the present invention, vectors containing said nucleic acids, host cells containing said vectors or nucleic acids, methods for the generation of DNA molecules using said DNA polymerases, kits containing said DNA polymerases, and uses thereof.

Abstract: The invention relates to a hydraulic braking system for a land vehicle, having at least one wheel brake; a master brake cylinder, which is designed to displace hydraulic fluid into the at least one wheel brake upon actuation of the braking system by the driver; a pump, which is designed to displace hydraulic fluid into the at least one wheel brake; a plurality of valve arrangements; a control unit, which is designed to actuate the pump and the plurality of valve arrangements; and a temporary store, which is connected hydraulically to the at least one wheel brake and to an input of the pump. The temporary store comprises a restoring element and is designed to accommodate a hydraulic fluid reserve volume during a rest state of the braking system, and to make the accommodated hydraulic fluid reserve volume available to the pump for displacement into the at least one wheel brake during an actuation state.

Abstract: A vehicle brake system comprises an electronic control unit (ECU) for controlling a vehicle brake arrangement, and an electric machine operating as a motor and a generator. The ECU controls valves and the electric machine so that, when a brake pedal is actuated, hydraulic fluid is supplied to a wheel brake from a master cylinder to generate a brake pressure. After a corresponding brake pressure is attained, the supply of hydraulic fluid is disabled, wherein the brake pressure effected by the hydraulic fluid is gradually dissipated, and, correspondingly, the electric machine is operated increasingly as a generator. Upon an increase of driver braking demand, hydraulic fluid is additionally supplied from the master cylinder to the wheel brake, and with decreasing vehicle speed, the electric machine is operated decreasingly as a generator, and, correspondingly, hydraulic fluid is supplied to the wheel brake from an intermediate accumulator and/or from the master cylinder.

Abstract: The present invention provides DNA polymerases and their use in various applications. The present invention also relates to uses and methods utilizing the DNA polymerase of the present invention for discriminating between matched and mismatched primers or detecting SNP or methylated cytosine. The present invention also relates to kits comprising such DNA polymerases.

Abstract: A vestibular stimulation electrode lead is described for conducting electrical stimulation signals generated by an implanted vestibular stimulation module. An extra-vestibular lead branch carries the stimulation signals from the stimulation module to a vestibular entry location. A stopper collar is bent away at a first discrete angle from a distal end of the extra-vestibular lead branch to penetrate into a vestibular structure at the entry location. An intra-vestibular electrode array is bent away at a second discrete angle from the stopper collar and has an outer surface with one or more electrode contacts for delivering the stimulation signals to vestibular neural tissue at a target location within the vestibular structure. The first and second discrete angles form a geometry of the stopper collar and intra-vestibular electrode array that limits insertion of the intra-vestibular electrode array beyond the target location within the vestibular structure.

Abstract: The invention relates to a hydraulic braking system for a land vehicle, having at least one wheel brake; a master brake cylinder, which is designed to displace hydraulic fluid into the at least one wheel brake upon actuation of the braking system by the driver; a pump, which is designed to displace hydraulic fluid into the at least one wheel brake; a plurality of valve arrangements; a control unit, which is designed to actuate the pump and the plurality of valve arrangements; and a temporary store, which is connected hydraulically to the at least one wheel brake and to an input of the pump. The temporary store comprises a restoring element and is designed to accommodate a hydraulic fluid reserve volume during a rest state of the braking system, and to make the accommodated hydraulic fluid reserve volume available to the pump for displacement into the at least one wheel brake during an actuation state.

Abstract: A brake system for a land vehicle includes at least one wheel brake; a pump configured to pump hydraulic fluid from the inlet side of the pump to the outlet side of the pump; at least one intermediate store for receiving hydraulic fluid; a hydraulic connection between the intermediate store and the inlet side of the pump; at least one first valve arrangement for blocking a hydraulic connection between the outlet side of the pump and the at least one wheel brake; at least one second valve arrangement for blocking a hydraulic connection between the at least one wheel brake and the inlet side of the pump; and at least one third valve arrangement for blocking a hydraulic connection between the outlet side of the pump and the intermediate store.

Abstract: A hydraulic brake system for a land vehicle includes a brake pedal; a wheel brake; and a master brake cylinder connected to the brake pedal by a brake booster and a pump. The outlet of the pump is connected to the wheel brake by a supply line and the inlet is connected to the wheel brake by a return line. The pump moves hydraulic fluid to the wheel brake. A temporary store is connected to the inlet of the pump and the wheel brake by the return line. A pressure reduction valve, arranged in the return line of the wheel brake, has a throttling effect in the open state. A control unit compensates for the difference between a total braking torque specified by the brake pedal and a generating braking torque provided by an electric machine by setting the hydraulic braking torque during a regenerative braking process of the vehicle.

Abstract: The present invention relates to DNA polymerases displaying increased substrate scope such as improved reverse transcriptase and DNA polymerase activities, as well as improved activities for incorporating and extending modified nucleotides. In particular, the present invention relates to DNA polymerases derived from wild-type Thermus aquaticus (Taq) polymerase, comprising the mutations S515R, I638F, and M747K with regard to the wild-type amino acid sequence. The present invention further relates to nucleic acids coding for the DNA polymerases of the present invention, vectors containing said nucleic acids, host cells containing said vectors or nucleic acids, methods for the generation of DNA molecules using said DNA polymerases, kits containing said DNA polymerases, and uses thereof.

Abstract: An implantable fenestration electrode delivers electrical stimulation signals for treatment of Meniere's disease. An electrode lead contains one or more signal wires for carrying a stimulation signal. An electrode tip at a terminal end of the electrode lead is configured for placement within a fenestration opening in an outer surface of a bony labyrinth of a patient with Meniere's disease without penetrating or impairing intra-labyrinthine membranes or neural tissue, and is adapted to deliver the stimulation signal via intra-labyrinthine fluid to the intra-labyrinthine neural tissue.

Abstract: The invention describes a vehicle brake system having a vehicle brake arrangement (10), an electronic control unit (ECU) for controlling a vehicle brake arrangement (10), and an electric machine which can be operated as a motor and as a generator. The electronic control unit (ECU) is designed to control valves (30, 32, 34, 36, 38, 40) of the vehicle brake arrangement (10) and the electric machine in such a way that, when a brake pedal (12) is actuated, hydraulic fluid is supplied to a wheel brake (24a; 24b) from a master cylinder (16) via a feed line (20) in order to generate a brake pressure at the wheel brake (24a; 24b).

Abstract: A vestibular stimulation electrode lead is described for conducting electrical stimulation signals generated by an implanted vestibular stimulation module. An extra-vestibular lead branch carries the stimulation signals from the stimulation module to a vestibular entry location. A stopper collar is bent away at a first discrete angle from a distal end of the extra-vestibular lead branch to penetrate into a vestibular structure at the entry location. An intra-vestibular electrode array is bent away at a second discrete angle from the stopper collar and has an outer surface with one or more electrode contacts for delivering the stimulation signals to vestibular neural tissue at a target location within the vestibular structure. The first and second discrete angles form a geometry of the stopper collar and intra-vestibular electrode array that limits insertion of the intra-vestibular electrode array beyond the target location within the vestibular structure.

Abstract: The present invention relates to DNA polymerases with a special mutation which have an enhanced mismatch discrimination, the preparation and use thereof. The thermostable DNA polymerases with this mutation are particularly suitable for diagnostic and molecular-biological methods, e.g., allele-specific PCR.

Abstract: The invention relates to a hydraulic brake system and a method for controlling a hydraulic brake system for a land vehicle having a predetermined holding capacity for hydraulic fluid and at least one wheel brake. The invention is characterized by detecting if a current holding capacity of the brake system has increased in relation to the predetermined holding capacity and, if so, by feeding hydraulic fluid to the at least one wheel brake in a controlled manner and an amount corresponding at least to the increase in capacity.

Abstract: A device and a method for reducing unwanted or undesireable excitations at a steering wheel include a sensor system with which unwanted excitation at a steering wheel and/or steering gear can be sensed. A closed-loop control unit is configured to generate an additional steering torque on the basis of the sensed unwanted excitation. A servomotor applies the additional steering torque to the steering gear.

Abstract: A method of managing a plurality of records, in which each record comprises a plurality of fields, involves determining a match signature for each record by evaluating a deterministic cluster definition against each record. The deterministic cluster definition comprises a logical association of the fields and defines at least one data cluster of the records. The data clusters are then identified by populating a match table with the match signatures. Each match signature is unique within the match table. Each record is associated with a respective one of the match signatures that are populated in the match table.

Abstract: The invention relates to a hydraulic brake system and a method for controlling a hydraulic brake system for a land vehicle having a predetermined holding capacity for hydraulic fluid and at least one wheel brake. The invention is characterized by detecting if a current holding capacity of the brake system has increased in relation to the predetermined holding capacity and, if so, by feeding hydraulic fluid to the at least one wheel brake in a controlled manner and an amount corresponding at least to the increase in capacity.