Abstract: A method and system for managing a treatment for a subject diagnosed with neovascular age-related macular degeneration (nAMD). Spectral domain optical coherence tomography (SD-OCT) imaging data of a retina of the subject is received. Retinal feature data is extracted for a plurality of retinal features using the SD-OCT imaging data, the plurality of retinal features being associated with at least one of a set of retinal fluids or a set of retinal layers. Input data formed using the retinal feature data for the plurality of retinal features is sent into a first machine learning model. A treatment level for an anti-vascular endothelial growth factor (anti-VEGF) treatment to be administered to the subject is predicted, via the first machine learning model, based on the input data.

Abstract: A method for identifying a type of choroidal neovascularization in a retina of a human eye is disclosed, the method comprising receiving, in a processor, optical coherence tomography data of the eye; generating, in the processor, volume segments of the eye using the optical coherence tomography data and a neural network; and identifying, in the processor, the type of choroidal neovascularization in the eye, using the volume segments, the type of choroidal neovascularization comprising one or more of the following: classic choroidal neovascularization and occult choroidal neovascularization.

Abstract: Methods and systems disclosed herein relate generally to systems and methods for predicting a future visual acuity of a subject by using machine-learning models. An image of at least part of a retina of a subject can be processed by one or more first machine-learning models to detect a set of retina-related segments. Segment-specific metrics that characterize a retina-related segment of the set of retina-related segments can be generated. The segment-specific metrics can be processed by using a second machine-learning model to generate a result corresponding to a prediction corresponding to a future visual acuity of the subject.

Abstract: Embodiments described herein provide methods and systems for predicting a subject response to a therapeutic. The methods and systems generally operate by using a machine learning (ML) component trained using time-series responses and image features to generate time-series responses of a subject to a therapeutic that has been administered to the subject.

Abstract: The invention relates to a belt retractor for winding up and unwinding a safety belt, with at least one force transmission element which is held by a first part of the belt retractor and which can be connected to a second part of the belt retractor, the force transmission element being held in a recess of the first part in such a way that it can be pressed axially into the recess of the first part, with the result that the connection to the second part is broken.

Abstract: The invention is concerned, inter alia, with a belt retractor (10) for a seat belt, with a belt reel (20) for winding up and unwinding the seat belt, and a lockable locking flange (40) which is connected to the belt reel and, prior to a locking action, is rotated together with the belt reel and, after a locking action, is blocked in its rotational movement. According to the invention, it is provided that the locking flange and the belt reel are secured against relative axial displacement.

Abstract: The invention relates to a belt retractor for winding up and unwinding a safety belt, with at least one force transmission element which is held by a first part of the belt retractor and which can be connected to a second part of the belt retractor, the force transmission element being held in a recess of the first part in such a way that it can be pressed axially into the recess of the first part, with the result that the connection to the second part is broken.

Abstract: The invention is concerned, inter alia, with a belt retractor (10) for a seat belt, with a belt reel (20) for winding up and unwinding the seat belt, and a lockable locking flange (40) which is connected to the belt reel and, prior to a locking action, is rotated together with the belt reel and, after a locking action, is blocked in its rotational movement. According to the invention, it is provided that the locking flange and the belt reel are secured against relative axial displacement.

Abstract: A belt force limiter which limits the belt force through the twisting of a torsion bar. The belt force limiter includes a flange, a reel for winding and unwinding the belt, as well as the torsion bar. Additionally, a shear pin or a deformable pin may be provided for locking the flange and the reel together, so that the relative turning of the flange and reel is prevented or impeded until the tensile force acting on the belt exceeds a preset level momentarily or over a preset period of time. Thus the force limitation is delayed or graduated. Furthermore, in a method for reducing the danger of injury to a vehicle's occupant by means of a restraining system the belt force is allowed to increase to an elevated level of force and then the belt force diminishes again before the belt force limitation begins.

Abstract: A belt force limiter which limits the belt force through the twisting of a torsion bar. The belt force limiter includes a flange, a reel for winding and unwinding the belt, as well as the torsion bar. Additionally, a shear pin or a deformable pin may be provided for locking the flange and the reel together, so that the relative turning of the flange and reel is prevented or impeded until the tensile force acting on the belt exceeds a preset level momentarily or over a preset period of time. Thus the force limitation is delayed or graduated. Furthermore, in a method for reducing the danger of injury to a vehicle's occupant by means of a restraining system the belt force is allowed to increase to an elevated level of force and then the belt force diminishes again before the belt force limitation begins.

Abstract: A belt force limiter which limits the belt force through the twisting of a torsion bar. The belt force limiter includes a flange, a reel for winding and unwinding the belt, as well as the torsion bar. Additionally, a shear pin or a deformable pin may be provided for locking the flange and the reel together, so that the relative turning of the flange and reel is prevented or impeded until the tensile force acting on the belt exceeds a preset level momentarily or over a preset period of time. Thus the force limitation is delayed or graduated. Furthermore, in a method for reducing the danger of injury to a vehicle's occupant by means of a restraining system the belt force is allowed to increase to an elevated level of force and then the belt force diminishes again before the belt force limitation begins.