Patents by Inventor Andreas MUELLER-HERMANN

Andreas MUELLER-HERMANN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220098641
    Abstract: It is disclosed a method for the detection of an amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by means of strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Amplification is detected by a detection system.
    Type: Application
    Filed: June 22, 2021
    Publication date: March 31, 2022
    Inventors: Christian Grunwald, Dmitry Cherkasov, Norbert Basler, Claus Becker, Hans-Joerg Hess, Andreas Mueller-Hermann
  • Publication number: 20220073967
    Abstract: A method for amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Amplification of a particular target sequence takes place more efficiently in case of perfect match complemetary base pair formation between the activator oligonucleotide and the corresponding target sequence.
    Type: Application
    Filed: October 28, 2021
    Publication date: March 10, 2022
    Inventors: Dmitry CHERKASOV, Norbert Basler, Claus Becker, Hans-Joerg Hess, Andreas Mueller-Hermann
  • Patent number: 11203780
    Abstract: A method for amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Amplification of a particular target sequence takes place more efficiently in case of perfect match complementary base pair formation between the activator oligonucleotide and the corresponding target sequence.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: December 21, 2021
    Inventors: Dmitry Cherkasov, Norbert Basler, Claus Becker, Hans-Joerg Hess, Andreas Mueller-Hermann
  • Patent number: 11072825
    Abstract: It is disclosed a method for the detection of an amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by means of strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Amplification is detected by a detection system.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: July 27, 2021
    Inventors: Christian Grunwald, Dmitry Cherkasov, Norbert Basler, Claus Becker, Hans-Joerg Hess, Andreas Mueller-Hermann
  • Publication number: 20210189479
    Abstract: A method is disclosed for detecting an amplification of nucleic acids in which use is essentially made of the fact that a predefined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target-sequence-specific activator oligonucleotide. The target-sequence-specific activator oligonucleotide brings about the separation of de-novo synthesized complementary primer elongation products by means of strand displacement, so that a new primer oligonucleotide can attach to the respective strand of the template. The complex thus formed, of a primer oligonucleotide and a template strand, can initiate a new primer elongation reaction. The primer elongation products thus formed, in turn, act again as templates, the result being an exponentially proceeding amplification reaction. In the method, a selective amplification is effected in that, for the first, second primer and activator oligonucleotide, variants are used which differ from the target sequence by at least one nucleotide.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 24, 2021
    Inventors: Christian Grunwald, Dmitry Cherkasov, Norbert BASLER, Claus BECKER, Hans-Joerg HESS, Andreas MUELLER-HERMANN
  • Publication number: 20210024978
    Abstract: It is disclosed a method for the detection of an amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by means of strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Amplification is detected by a detection system.
    Type: Application
    Filed: February 25, 2019
    Publication date: January 28, 2021
    Applicant: AGCT GmbH
    Inventors: Christian GRUNWALD, Dmitry CHERKASOV, Norbert BASLER, Claus BECKER, Hans-Joerg HESS, Andreas MÜLLER-HERMANN
  • Publication number: 20200239933
    Abstract: A method for amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Amplification of a particular target sequence takes place more efficiently in case of perfect match complemetary base pair formation between the activator oligonucleotide and the corresponding target sequence.
    Type: Application
    Filed: February 20, 2020
    Publication date: July 30, 2020
    Inventors: Dmitry CHERKASOV, Norbert BASLER, Claus BECKER, Hans-Joerg HESS, Andreas MUELLER-HERMANN
  • Patent number: 10612082
    Abstract: A method for amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: April 7, 2020
    Assignee: AGCT GmbH
    Inventors: Dmitry Cherkasov, Norbert Basler, Claus Becker, Hans-Joerg Hess, Andreas Mueller-Hermann
  • Publication number: 20190185914
    Abstract: It is disclosed a method for amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by means of strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Here, the activator oligonucleotide itself does not function as a template and preferably is inert over a primer extension reaction.
    Type: Application
    Filed: August 21, 2017
    Publication date: June 20, 2019
    Inventors: Dmitry CHERKASOV, Norbert BASLER, Claus BECKER, Hans-Joerg HESS, Andreas MUELLER-HERMANN
  • Publication number: 20150086981
    Abstract: The invention relates to a novel method for the enzymatic marking of nucleic acid chains (target sequences) with nucleotide conjugates. Under reaction conditions, said nucleotide conjugates are able to bind to a target sequence, and can be incorporated into the complementary growing strand by way of a polymerase. The nucleotide conjugates can be used for sequencing nucleic acid chains.
    Type: Application
    Filed: May 4, 2012
    Publication date: March 26, 2015
    Applicant: GENOVOXX GMBH
    Inventors: Dmitry Cherkasov, Claus Becker, Norbert Basler, Andreas Müller-Hermann, Petra Van Husen