Abstract: Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.

Abstract: Methods for inducing anti-phosphorylated Tau antibodies without inducing a severe adverse event in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist and a Tau phosphopeptide presented on the surface of the liposome.

Abstract: Methods for inducing a sustained immune response against phosphorylated Tau in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist, a helper T-cell epitope, a lipidated CpG oligonucleotide, and a Tau phosphopeptide presented on the surface of the liposome to thereby obtain the sustained immune response.

Abstract: Methods for inducing an immune response against tau protein in a subject suffering from a neurodegenerative disease, disorder or condition, such as Alzheimer's Disease, are described. The methods include administering a liposomal priming composition containing tau peptides, preferably phosphorylated tau peptides, and a conjugate boosting composition containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier.

Abstract: Methods for inducing anti-phosphorylated Tau antibodies without inducing a severe adverse event in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist and a Tau phosphopeptide presented on the surface of the liposome.

Abstract: Methods for inducing an immune response against tau protein in a subject suffering from a neurodegenerative disease, disorder or condition, such as Alzheimer's Disease, are described. The methods include administering a liposomal priming composition containing tau peptides, preferably phosphorylated tau peptides, and a conjugate boosting composition containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier.

Abstract: The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.

Abstract: A liposomal vaccine composition comprising: a. A ?-amyloid (A?)-derived peptide antigen displayed on the surface of the liposome that comprises, consists essentially of or consists of amino acids 1-15 of A?, b. An adjuvant comprising monophosphoryl lipid A (MPLA) is used for inducing an anti-A? immune response in a human subject without inducing a serious adverse event. The ?-amyloid (A?)-derived peptide antigen (SEQ ID NO: 1) is administered in an amount of 300-2000 ?g, preferably around 1000 ?g. The MPLA is administered in an amount of 15-600 ?g, preferably around 175 ?g. The liposomal vaccine composition is administered intramuscularly or subcutaneously.

Abstract: The invention provides anti-Tau antibodies and methods of using the same.

Abstract: The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.

Abstract: Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.

Abstract: The invention provides anti-Tau antibodies and methods of using the same.

Abstract: Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.

Abstract: The invention provides anti-Tau antibodies and methods of using the same.

Abstract: An electrical connector includes a housing which can be electrically connected on a connection side to an electrical connection part. On a contact side, one or more contacts are provided to electrically contact one or more counter-contacts of a printed circuit board. At least one latching peg assembly including two functional elements passes through an opening of the printed circuit board and can be moved by an actuation element from a non-expanded released position into an expanded latched position in which its diameter on the side of the opening which faces away from the housing is greater than the diameter of the opening of the printed circuit board. One of the functional elements is arranged on the actuation device and another element is arranged on a component of the connector which is movable relative to the actuation device.

Abstract: Methods for inducing an immune response against tau protein in a subject suffering from a neurodegenerative disease, disorder or condition, such as Alzheimer's Disease, are described. The methods include administering a liposomal priming composition containing tau peptides, preferably phosphorylated tau peptides, and a conjugate boosting composition containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier.

Abstract: A stirring tool for a stirrer for stirring a mixture comprises a connecting element for connecting the stirring tool to a stirring drive, drivable about a rotational axis, of the stirrer, a carrier ring, a plurality of stirring spokes disposed between the connecting element and the carrier ring, and at least one stirring boss which projects radially on the carrier ring. Two adjacent stirring spokes are arranged mutually offset in the direction of the rotational axis.

Abstract: Methods for inducing anti-phosphorylated Tau antibodies without inducing a severe adverse event in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist and a Tau phosphopeptide presented on the surface of the liposome.

Abstract: The present invention relates an electrical connector (1) for connecting one or more electrical connectors to a board, in particular to a printed circuit board, which comprises at least the following features: a housing (15) which can be electrically connected on a connection side (131) of the electrical connector (1) to an electrical connection part (2) and which comprises, on a contact side (141) of the electrical connector (1), at least one or more contacts (4), in order to electrically contact one or more counter-contacts (31) of the printed circuit board (3), at least one latching peg arrangement (5) which, in the mounted state on the printed circuit board (3), passes through an opening (32) of the printed circuit board (3) and which can be moved from a non-expanded position—a release position—into an expanded position—a latching position—, in which its diameter on the side of the opening (32), which faces away from the housing (15), is greater than the diameter of the opening (32) of the printed circuit

Abstract: A stirring tool for a stirrer for stirring a mixture comprises a connecting element for connecting the stirring tool to a stirring drive, drivable about a rotational axis, of the stirrer, a carrier ring, a plurality of stirring spokes disposed between the connecting element and the carrier ring, and at least one stirring boss which projects radially on the carrier ring. Two adjacent stirring spokes are arranged mutually offset in the direction of the rotational axis.