Abstract: An apparatus for the intermittent application of a liquid to pasty medium onto an application surface, comprising an application valve which can be switched between an open and a closed state and is intended for dispensing the medium onto the application surface, a volumetric delivery pump for metering a volume of the medium to be passed on to the application valve, and a drive for operating the volumetric delivery pump is, inter alia, described and illustrated. The characteristic feature consists in that the apparatus has an electronic controller which, in each case cyclically, activates the drive and the application valve in dependence on each other.

Abstract: A device for spraying adhesive onto a substrate or workpiece, for example, an automotive workpiece, includes at least one spray nozzle for discharging the adhesive having at least two adhesive inlets and at least two regions of adhesive outlets. One of the regions of adhesive outlets which can be supplied separately with a width of less than 25 mm is connected to precisely one of the adhesive inlets.

Abstract: A nozzle arrangement for applying fluids to a substrate has a main body which is able to be connected to a mounting region of a distributor and which has an end-side side surface. At least one first outlet nozzle for the fluid to be applied to the substrate is provided in or on the end-side side surface of the main body. A first fluid channel system is formed in the main body, via which the at least one first outlet nozzle is connected in terms of flow to a first fluid connector, which is provided in the main body of the nozzle arrangement. The nozzle arrangement is a monolithic component produced by an additive production method.

Abstract: A nozzle arrangement applies fluids, in particular thermoplastic adhesives, to a substrate. The nozzle arrangement and the substrate move relative to one another in a first direction. The nozzle arrangement has a main body which is exchangeably connected to a mounting region of a distributor and which has an end-side side surface extending in a second direction running at least substantially perpendicular to the first direction. The end-side side surface of the main body can have mutually adjacently arranged first outlet nozzles for the fluid to be applied formed in a first row extending along the second direction and mutually adjacently arranged second outlet nozzles for a second fluid formed in a second row extending along the second direction and that is parallel to the first row.

Abstract: A flow detector for monitoring an adhesive flow in an adhesive applicator includes a sensor device arranged in the adhesive flow. The sensor device is formed as a capacitive sensor.

Abstract: Through the use of different ceramic heat insulation coatings (7, 13) on turbine blades, it is possible to produce or restore different configurations of gas turbines, which are then optimized for a respective baseload operation application or peak load operation application. Differences in the sprayed-on heat insulation coatings (7, 13) can be generated by means of a different material composition of the powder, for example zirconium oxide, by means of a different number of layers (10), by means of different coating thicknesses and/or by means of different porosities.

Abstract: A method for protecting an adhesive delivery apparatus (10) having an adhesive outlet opening (16) through which adhesive can be extracted from the adhesive delivery apparatus (10), in particular toward a surface (13) which is to be wetted with the adhesive, which comprises feeding of an air moisture protection gas (41) into the region of the adhesive outlet opening (16), is described and represented.

Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a BCMA-binding moiety comprising (i) the variable domains of humanized antibody J22.9-ISY, and (ii) a heavy chain constant region comprising a D265C mutation; and (c) a protease-cleavable linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate, particularly for use in the treatment of multiple myeloma.

Abstract: The use of different ceramic layers allows different configurations of gas turbines to be produced each of which is optimized for a respective use of base load operation or peak load operation.

Abstract: A method for monitoring a condenser pressure protection curve with a polygon function of a turbine using an SPS safety monitoring system, includes reading a first measurement value and a second measurement value, standardizing the second measurement value to a value scale of the first measurement value using a standardizing module of the SPS safety monitoring system, comparing the first measurement value with the standardized second measurement value using a comparison module of the SPS safety monitoring system, and generating an output signal in response to the standardized second measurement value exceeding the first measurement value.

Abstract: A device (10) for applying a fluid to a moving substrate (36) includes a nozzle head (15a, 15b, 15c, 15d) with an inlet opening (26, 26c) and an outlet opening (29a, 29b, 29c, 29d). The device further includes a supply station (11) with a fastening surface (17) with a mouth region (20a) of a fluid duct. The nozzle head is arranged so as to be pivotable relative to the fastening surface about a pivot axis (38a). The inlet opening (26, 26c) and the mouth region (20a) of the fluid duct are arranged in alignment along the pivot axis (38a).

Abstract: The invention relates, inter alia, to a device (10) for applying a plurality of threads (17) of a fluid, such as adhesive or lotion, to a moving web-like substrate (11), having a plurality of outlet openings (15a, 15b, 15c, 15d, 15e) for the threads of fluid (17, 17a, 17b, 17c), wherein each outlet opening is disposed between a pair of flow openings (16a, 16b, 16c, 16d, 16e), through which a flow fluid (21), in particular compressed air, flows in order to achieve thread oscillation. The special feature consists, inter alia, in that the outlet openings are disposed along a curved path (22, 22?).

Abstract: A fluid application device having an applicator head, a slot die assembly and a securing mechanism for securing the slot die assembly to the applicator head is provided. The slot die assembly includes a die extruder comprising one or more fluid input ports configured to receive a fluid from the applicator head, a shim positioned adjacent to the die extruder, and a plate positioned adjacent to the shim on a side of the shim opposite from the die extruder. The securing mechanism includes a securing component at one of the applicator head and the slot die assembly and a corresponding securing component at the other of the applicator head and slot die assembly.

Abstract: A nozzle assembly for applying a fluid on a substrate includes a plurality of plates, a first fluid conduit having a first inlet configured and a first discharge orifice configured to discharge a first fluid generally in a first direction, and a second fluid conduit having a second inlet, a second discharge orifice configured to discharge a second fluid generally in a second direction intersecting the first direction and a third discharge orifice. The second fluid acts on the first fluid at the first discharge orifice. A method of applying the fluid on the substrate includes continuously feeding the substrate by the nozzle assembly, discharging, in the first direction, the first fluid from the first discharge orifice onto the substrate, discharging, in the second direction, the second fluid from the second discharge orifice, and discharging, generally in the first direction, the second fluid from the third orifice.

Abstract: A method for testing an overspeed protection apparatus of a single-shaft system that includes: a) operating the system at nominal speed and under electrical load, wherein the load is selected to be low enough that, after dropping the load, the speed of the system rises such that the speed remains below steam turbine threshold speed lower than gas turbine threshold speed, such that first overspeed protection is triggered when the speed of the steam turbine reaches the steam turbine threshold speed, and second overspeed protection is triggered when the speed of the gas turbine reaches the gas turbine threshold speed; b) dropping the load; c) increasing the mass flow of the steam introduced into the steam turbine and/or of the fuel introduced into the gas turbine such that the speed of the steam turbine reaches the steam turbine threshold speed; d) testing whether the first overspeed protection is triggered.

Abstract: A device (10) for applying a fluid to a moving substrate (36) includes a nozzle head (15a, 15b, 15c, 15d) with an inlet opening (26, 26c) and an outlet opening (29a, 29b, 29c, 29d). The device further includes a supply station (11) with a fastening surface (17) with a mouth region (20a) of a fluid duct. The nozzle head is arranged so as to be pivotable relative to the fastening surface about a pivot axis (38a). The inlet opening (26, 26c) and the mouth region (20a) of the fluid duct are arranged in alignment along the pivot axis (38a).

Abstract: The invention relates to conjugates comprising amatoxins and antibodies, in particular amatoxins linked to antibodies comprising specific cysteine residues.

Abstract: A flow detector for monitoring an adhesive flow in an adhesive applicator includes a sensor device arranged in the adhesive flow. The sensor device is formed as a capacitive sensor.

Abstract: The invention relates to applying a liquid to pasty hot-melt adhesive to a substrate (44), comprising a template (29), having at least one cavity (38) for the hot-melt adhesive, and also comprising an adhesive-transfer infeed (33), which is assigned to the template (29) and through which the adhesive can be introduced into the cavity (38). The special feature consists in that the apparatus (10) further comprises a transporting-fluid-supply opening (35), assigned to the template (29), and a device for displacing (13, 15), in particular pivoting, the template (29) between a first position, in which the cavity (38) is assigned to the adhesive-transfer infeed (33), and a second position, in which the cavity (38) is assigned to the transporting-fluid-supply opening (35), and therefore the adhesive, in the second position, can be discharged from the cavity (38) by a transporting fluid flowing through the transporting-fluid-supply opening (35).

Abstract: A fluid application device having an applicator head, a slot die assembly and a securing mechanism for securing the slot die assembly to the applicator head is provided. The slot die assembly includes a die extruder comprising one or more fluid input ports configured to receive a fluid from the applicator head, a shim positioned adjacent to the die extruder, and a plate positioned adjacent to the shim on a side of the shim opposite from the die extruder. The securing mechanism includes a securing component at one of the applicator head and the slot die assembly and a corresponding securing component at the other of the applicator head and slot die assembly.