Abstract: Methods are provided for efficient training of convoluted neural networks using computer-assisted microscope image acquisition and pre-classification of training images for biological objects of interest. The methods combine use of an automated scanning platform, on-the-fly image analysis parallel to the scanning process, and a user interface for review of the pre-classification performed by the software.

Abstract: The current invention relates to a method of identifying changes in biopolymers, especially in chromosomal DNA, using two or more different sets of labeled detector molecules, as well as to a diagnostic kit for detecting these changes.

Abstract: The current invention relates to a method of identifying changes in biopolymers, especially in chromosomal DNA, using two or more different sets of labelled detector molecules, as well as to a diagnostic kit for detecting these changes.

Abstract: The present invention is relative to a method for the purposeful application of at least one reagent onto immobilized biological material as well as to a diagnostic kit containing small-area, local covers on which at least one reagent is fixed for contact hybridization.

Abstract: A method is provided for comparing the relative copy number of nucleic sequences of two or more nucleic acid sequence collectives which includes hybridizing differentially labeled i) nucleic acid sequence collectives; ii) a reference nucleic acid sequence collective; and iii) a calibration nucleic acid sequence collective. The method includes determining quotient values for the reference nucleic acid sequence and the calibration nucleic acid sequence and using correction curve calculations to determine a final relative copy number of the nucleic acid sequences of the nucleic acid sequence collective.

Abstract: The present invention is relative to a method for the purposeful application of at least one reagent onto immobilized biological material as well as to a diagnostic kit containing small-area, local covers on which at least one reagent is fixed for contact hybridization.

Abstract: An apparatus for the observation and treatment of the eye with a laser, having an illumination light source, whose light is focussed on the part of the eye to be observed and which preferably contains a laser, a scanning device, which generates a scanning movement of the light of the illumination light source on the background of the eye, a detector device, which receives the reflected light, an evaluation and synchronization unit, which generates from the time-sequential signal output of the detector device a visual representation of the portions of the eye to be treated and shows the visual representation, on a monitor, and a treatment laser device, whose light can be reflected on the part of the eye to be treated. The apparatus provides that a visual representation in which the location or locations to be treated are marked, can be superimposed on the visual representation of the eye at least on the monitor, and a control unit aligns the laser to the marked location.

Abstract: Disclosed is an apparatus for aligning a focused beam of light and, in particular, a laser beam onto a surface using optical elements which image, respectively shape, deflect and align the beam of light.The present invention is distinguished by a deflecting optical element having, in addition, a focusing effect.

Abstract: Disclosed is an apparatus for examining objects having an illumination light source, the light of which can be focussed on the part of the object to be examined, a scanning device, which generates a scanning movement of the light beam from the illumination light source over the section to be examined and which is provided with beam-deflecting and beam-imaging optical elements, a sensor device, which receives the light reflected from said section to be examined, and an evaluation and synchronization unit, which produces an image of said section to be examined from the time-sequential output signal from said sensor device. The invented apparatus is distinguished by the fact that the optical axis of the examination and/or illumination beam can be shifted in a plane of said pupils in order to generate a stereoscopic image, and that the images produced with varying positions of the optical axes can be overlapped in order to produce a stereo image.

Abstract: An apparatus for producing an image of an object and, in particular, for examining the eye, having an illumination light source, the light of which can be focussed onto the section of the object to be examined, a scanning device, which generates a scanning movement of the source of the illumination light over the section to be examined and which is provided with beam-deflecting and image-forming optical elements, a detector device, which receives the light reflected from the section to be examined, and an evaluation and sychronization unit, which produces an image of the selected structures of the object from the time-sequential output signal from the detector device at least two image forming optical elements, which can be interchanged in order to alter the horizontal deflection angle, or image magnification in the horizontal direction, are provided in the beam path between the beam-deflecting elements.

Abstract: An instrument for the examination and/or treatment of the eye having an examination device designed for the examination of the fundus oculi and having a contact eyeglass, which is provided with a lens which can be placed on the eye, the eye-facing surface of the lens being adapted to the curve of the cornea. The lens which is placed on the eye has no spherical power at least in the region of the optical axis.

Abstract: An apparatus for producing images of an object and, in particular, for observing the rear portions of the eye by an illumination device, the light of which is focused on the object to be imaged and which preferably is provided with at least one laser. A scanning device, which produces a scanning motion of the light from the illumination device on the object to be imaged. A detector device has at least one detector which receives the light reflected from the object to be imaged an assessement and synchronization unit produces the image from the time-sequential output signal from the detector device.It is possible to gain essential ground-laying information about the object to be imaged, e.g. the fundus of the eye, by special types of illumination and/or the analysis of the scattered back light according to the most varied criteria.