Abstract: Provided herein are methods of using the antibodies that bind to RGMc to treat and diagnose iron-related disorders.

Abstract: Methods and devices for coding and identifying plate-type workpieces are provided. The methods include: coding a workpiece by producing a code with a local modification in a material structure of a base material of the workpiece within a coding region, reading out the code by performing an eddy-current measurement of a local distribution of an electrical conductivity and/or a permeability of the base material by an eddy-current sensor along a reading-out section in a reading region at least partially including the coding region, a signal calibrated to a distance of the eddy-current sensor from a surface of the reading region being determined for reading out the code, storing the read-out code in a storage device, repeating the reading out of the code by repeatedly performing the eddy-current measurement, and identifying the workpiece by comparing the stored read-out code in the storage device and the repeated read-out code.

Abstract: The invention relates to a process for producing a foam molded part, wherein a foamable material S comprising a thermoplastic polymer matrix M and at least one foaming agent F is foamed by foam injection molding. The polymer matrix M is preferably based on at least one thermoplastic styrene copolymer, such as ABS and ASA, and wherein the at least one foaming agent F is selected from chemical foaming agents, releasing carbon dioxide, and physical foaming agents, being carbon dioxide or nitrogen.

Abstract: Optical arrangements for processing a workpiece include a fiber laser arrangement for emitting laser radiation, a fiber arrangement directly coupled to the fiber laser arrangement and configured to guide the laser radiation in a direction to the workpiece to be processed, the fiber arrangement including a transport fiber having a fiber core and at least one fiber cladding surrounding the fiber core, and at least one coupling device for coupling a portion of the laser radiation guided in the fiber arrangement into at least one fiber cladding of the transport fiber. The coupling device has a spectral bandwidth of at least the same magnitude as a spectral bandwidth of the laser radiation. The fiber laser arrangement is configured to change a beam profile of the guided laser radiation to shift the spectral bandwidth of the laser radiation relative to the spectral bandwidth of the coupling device.

Abstract: A method for encoding a plate-like workpiece comprising: defining an encoding area; applying a magnetic layer to the surface of the workpiece; fusing parts of the magnetic layer to the surface of the workpiece by acting on the workpiece with radiation within the encoding area; cooling the workpiece; removing the non-fused parts of the magnetic layer. The method permits the workpieces to be trackable in a simple manner, irrespective of surface treatments that may possibly be carried out or are to be carried out later.

Abstract: Provided herein are methods of using the antibodies that bind to RGMc to treat and diagnose iron-related disorders.

Abstract: Disclosed herein are anti-RGMa antibodies and methods of using these antibodies to treat multiple sclerosis, including relapsing forms of multiple sclerosis such as relapsing-remitting multiple sclerosis or relapsing-secondary progressive multiple sclerosis.

Abstract: Provided herein are methods of using the antibodies that bind to RGMc to treat and diagnose iron-related disorders.

Abstract: Methods, devices and systems for laser-supported plasma cutting or plasma welding of a workpiece. In one aspect, a method includes producing a plasma beam which extends in an expansion direction between an electrode and a processing location on the workpiece, the plasma beam having, with respect to a center axis of the plasma beam that extends in the expansion direction, an inner central region and an outer edge region, and supplying laser radiation to the outer edge region of the plasma beam. The laser radiation supplied to the outer edge region extends parallel with the center axis of the plasma beam.

Abstract: Optical arrangements for processing a workpiece include a fiber laser arrangement for emitting laser radiation, a fiber arrangement directly coupled to the fiber laser arrangement and configured to guide the laser radiation in a direction to the workpiece to be processed, the fiber arrangement including a transport fiber having a fiber core and at least one fiber cladding surrounding the fiber core, and at least one coupling device for coupling a portion of the laser radiation guided in the fiber arrangement into at least one fiber cladding of the transport fiber. The coupling device has a spectral bandwidth of at least the same magnitude as a spectral bandwidth of the laser radiation. The fiber laser arrangement is configured to change a beam profile of the guided laser radiation to shift the spectral bandwidth of the laser radiation relative to the spectral bandwidth of the coupling device.

Abstract: Provided herein are antibodies and methods of using the antibodies to treat, prevent, modulate, attenuate and diagnose iron-related disorders.

Abstract: Disclosed herein are anti-RGMa antibodies and methods of using these antibodies to treat multiple sclerosis, including relapsing forms of multiple sclerosis such as relapsing-remitting multiple sclerosis or relapsing-secondary progressive multiple sclerosis.

Abstract: Methods, devices and systems for laser-supported plasma cutting or plasma welding of a workpiece. In one aspect, a method includes producing a plasma beam which extends in an expansion direction between an electrode and a processing location on the workpiece, the plasma beam having, with respect to a center axis of the plasma beam that extends in the expansion direction, an inner central region and an outer edge region, and supplying laser radiation to the outer edge region of the plasma beam. The laser radiation supplied to the outer edge region extends parallel with the center axis of the plasma beam.

Abstract: A method for the production of an immunoglobulin or a functional fragment thereof in a prokaryotic host cell comprises transforming the host cell with (a) a first nucleic acid molecule comprising a nucleic acid sequence encoding a VL and a CL region and (b) a second nucleic acid molecule comprising a nucleic acid sequence encoding a VH, a CH1, a CH2 and at least a portion of a CH3 region, The host cell is within culture medium. The host cell is cultured under conditions so as to allow the host cell (a) to express (1) the VL and a CL region and (2) the VH, the CH1, the CH2 and the portion of the CH3 region, and (b) to secrete (a)(1) and (a)(2) to the periplasm of the host cell and thereafter to the culture medium of the host cell. Characteristically, (a)(1) and (a)(2) interact to form the immunoglobulin or functional fragment thereof.

Abstract: The invention concerns antibodies and antibody fragments, specifically recognising the EphB4 receptor comprising heavy chains and light chain, comprising light and heavy CDR's, and their use as medicament for the treatment of pathological angiogenesis, in particular cancer therapy.

Abstract: The present invention inter alia relates to methods for the prevention, amelioration or treatment of medical conditions associated with an alteration in normal goblet cell function. It also relates to methods of screening for disease-relevant markers indicative of an increased risk of a subject of developing such a condition. It furthermore relates to an animal model useful for studying said conditions and the molecular mechanisms underlying them, and uses of that animal model, for example for the identification of diagnostic markers or agents useful for the prevention, amelioration, or treatment of a goblet cell-related disorder. Novel agents useful in the above methods, and novel pharmaceutical compositions are likewise provided. The invention further relates to screening methods for agonists and antagonists useful for performing said methods.

Abstract: The present invention relates to novel (meth)acrylic esters of polyalkoxylated trimethylolpropane of the formula where EO is O—CH2-CH2- PO is independently at each instance O—CH2-CH(CH3)- or O—CH(CH3)-CH2- n1, n2 and n3 are independently 4, 5 or 6, n1+n2+n3 is 14, 15 or 16, m1, m2 and m3 are independently 1, 2 or 3, m1+m2+m3 is 4, 5 or 6, R1, R2 and R3 are independently H or CH3, a simplified process for preparing these esters and the use of reaction mixtures thus obtainable.

Abstract: The present invention relates to novel (meth)acrylic esters of polyalkoxylated trimethylolpropane of the formula where AO is for each AO independently at each instance EO, PO or BO where EO is O—CH2-CH2- PO is independently at each instance O—CH2-CH(CH3)- or O—CH(CH3)-CH2- BO is independently at each instance O—CH2-CH(CH2-CH3)- or O—CH(CH2-CH3)-CH2- p1+p2+p3 is 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74 or 75, R1, R2 and R3 are independently H or CH3, a simplified process for preparing these esters and the use of reaction mixtures thus obtainable.

Abstract: The present invention relates to novel mixtures of (meth)acrylic esters of polyalkoxylated trimethylolpropane of the formula where AO is for each AO independently at each instance EO, PO or BO where EO is O—CH2-CH2- PO is independently at each instance O—CH2-CH(CH3)- or O—CH(CH3)-CH2- BO is independently at each instance O—CH2-CH(CH2-CH3)- or O—CH(CH2-CH3)-CH2- p1+p2+p3 is 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74 or 75, R1, R2 and R3 are independently H or CH3, a simplified process for preparing these ester mixtures and the use of reaction mixtures thus obtainable.

Abstract: The present invention relates to novel (meth)acrylic esters of polyalkoxylated trimethylolpropane of the formula where EO is O—CH2-CH2- PO is independently at each instance O—CH2-CH(CH3)- or O—CH(CH3)-CH2- n1, n2 and n3 are independently 4, 5 or 6, n1+n2+n3 is 14, 15 or 16, m1, m2 and m3 are independently 1, 2 or 3, m1+m2+m3 is 4, 5 or 6, R1, R2 and R3 are independently H or CH3, a simplified process for preparing these esters and the use of reaction mixtures thus obtainable.