Abstract: The present invention relates to a composition comprising an oligomeric compound comprising one or more tricyclo-deoxyribonucleic acid (tc-DNA) nucleosides and one or more lipid moiety, wherein said one or more lipid moiety is covalently linked to said oligomeric compound either directly or via a spacer, and wherein preferably said oligomeric compound comprises from 5 to 40 monomer subunits, as well as pharmaceutical compositions thereof and their uses in the prevention or treatment of neuromuscular or musculoskeletal diseases such as Duchenne muscular dystrophy or Steinert disease.

Abstract: The present invention relates to a composition comprising an oligomeric compound comprising one or more tricyclo-deoxyribonucleic acid (tc-DNA) nucleosides and one or more lipid moiety, wherein said one or more lipid moiety is covalently linked to said oligomeric compound either directly or via a spacer, and wherein preferably said oligomeric compound comprises from 5 to 40 monomer subunits, as well as pharmaceutical compositions thereof and their uses in the prevention or treatment of neuromuscular or musculoskeletal diseases such as Duchenne muscular dystrophy or Steinert disease.

Abstract: In some embodiments, disclosed herein are oligomeric compounds which include one or more tricyclo-deoxyribonucleic acid (tc-DNA) nucleosides and one or more 2?-modified ribonucleic acid (2?-modified-RNA) nucleosides, and which optionally also include one or more non-nucleotides, each of which is joined by a plurality of internucleoside linkages, including pharmaceutical compositions and methods of using the pharmaceutical compositions for the treatment of diseases including Duchenne muscular dystrophy treatment of familial dysautonomia, spinal muscular atrophy, ataxia telangiectasia, congenital disorder of glycosylation, fronto-temporal dementia, Parkinsonism linked to chromosome 17, Niemann-Pick disease type C. neurofibromatosis type 1, neurofibromatosis type 2, megalencephalic leukoencephalopathy with subcortical cysts type 1. Pelizaeus-Merzbacher disease, Pompe disease, myotonic dystrophy type 2 (DM2 or proximal myotonic myopathy), and myotonic dystrophy type 1 (DM1 or Steinert disease).

Abstract: In some embodiments, disclosed herein are oligomeric compounds which include one or more tricyclo-deoxyribonucleic acid (tc-DNA) nucleosides and one or more 2?-modified ribonucleic acid (2?-modified-RNA) nucleosides, and which optionally also include one or more non-nucleotides, each of which is joined by a plurality of internucleoside linkages, including pharmaceutical compositions and methods of using the pharmaceutical compositions for the treatment of diseases including Duchenne muscular dystrophy treatment of familial dysautonomia, spinal muscular atrophy, ataxia telangiectasia, congenital disorder of glycosylation, fronto-temporal dementia, Parkinsonism linked to chromosome 17, Niemann-Pick disease type C, neurofibromatosis type 1, neurofibromatosis type 2, megalencephalic leukoencephalopathy with subcortical cysts type 1, Pelizaeus-Merzbacher disease, Pompe disease, myotonic dystrophy type 2 (DM2 or proximal myotonic myopathy), and myotonic dystrophy type 1 (DM1 or Steinert disease).

Abstract: The present invention relates to a composition comprising an oligomeric compound comprising one or more tricyclo-deoxyribonucleic acid (tc-DNA) nucleosides and one or more lipid moiety, wherein said one or more lipid moiety is covalently linked to said oligomeric compound either directly or via a spacer, and wherein preferably said oligomeric compound comprises from 5 to 40 monomer subunits, as well as pharmaceutical compositions thereof and their uses in the prevention or treatment of neuromuscular or musculoskeletal diseases such as Duchenne muscular dystrophy or Steinert disease.

Abstract: In some embodiments, disclosed herein are oligomeric compounds which include one or more tricyclo-deoxyribonucleic acid (tc-DNA) nucleosides and one or more 2?-modified ribonucleic acid (2?-modified-RNA) nucleosides, and which optionally also include one or more non-nucleotides, each of which is joined by a plurality of internucleoside linkages, including pharmaceutical compositions and methods of using the pharmaceutical compositions for the treatment of diseases including Duchenne muscular dystrophy treatment of familial dysautonomia, spinal muscular atrophy, ataxia telangiectasia, congenital disorder of glycosylation, fronto-temporal dementia, Parkinsonism linked to chromosome 17, Niemann-Pick disease type C, neurofibromatosis type 1, neurofibromatosis type 2, megalencephalic leukoencephalopathy with subcortical cysts type 1, Pelizaeus-Merzbacher disease, Pompe disease, myotonic dystrophy type 2 (DM2 or proximal myotonic myopathy), and myotonic dystrophy type 1 (DM1 or Steinert disease).

Abstract: A device for preparing hot water by recovering heat from waste water includes a heat pump which has a compressor and an evaporator. The evaporator supplies thermal energy to a hot water reservoir which is disposed above the compressor. At least one heat pipe thermally connects the hot water reservoir to the compressor of the heat pump and is constructed to dissipate waste heat produced during operation of the compressor to the hot water reservoir.

Abstract: A device which is used for preparing hot water, in particular for domestic applications, by recovering heat from waste water, preferably waste water from a sink and/or a dishwasher or washing machine includes a heat pump having an evaporator and a condenser, and a waste water container which collects the waste water. The waste water container is placed in thermal contact with the evaporator and constructed as a cylindrical hollow body with a waste water inlet and a waste water outlet. A hot water reservoir is in thermal contact with the condenser. Accommodated in the hollow body of the waste water container is an agitating apparatus, and a valve is provided at the waste water outlet to cut a flow of waste water through the waste water outlet.

Abstract: An ice maker includes an ice making bowl having at least one compartment in the shape of a rotational body and adapted to freeze water to form ice. A heating facility is assigned to the ice making bowl to heat the compartment. An ice body ejection facility has an ejection element which is maintained under a spring force to seek a contact with a surface region of an ice body for discharging the ice body from the compartment solely by the spring force after the ice body has begun to thaw.

Abstract: An icemaker for a refrigerator is provided that includes a mold container which may be filled with water, an air space adjacent to a water level in the mold container, and an air humidifying device for increasing the level of humidity in the air above the water level. Water is administered to the mold container and is cooled and ice crystals form when a given crystallization temperature of the water of below zero degrees C is reached.

Abstract: In an attachment part (13) for an electrical plug-in connection, wherein a frame member (16) is provided having inside surfaces (17) which are formed to essentially match the outside contour of a first electrical connecting element (3), and wherein the frame member (16) can be attached to a second electrical connecting element (6) and forms with its inside surfaces (17) a through opening (18) in the connection direction of the electrical connecting elements (3, 6), and wherein the first electrical connecting element (3) can be guided so as to be freely movable, it is proposed for reducing manufacturing and material costs and for improving compatibility with existing plugs that a safety wire clip (90) is movably connected with the frame member (16), and that the safety wire clip (90) is formed so as to secure a first electrical connecting element (3) connected with the second electrical connecting element (6) so that it cannot be pulled out.

Abstract: The invention relates to an apparatus for establishing an electrical and/or optic connection of a first and a second component with a third component with connection means 14, 15 for electrical and/or optic connection of the first and second component with each other, whereby the connection means 14, 15 allow mechanical free-play between the first and second component, with a connection link 13, 16 each for the first and the second component for electrical and/or optic connection of the first and the second with a third component, and with an apparatus 31, 32, 33, 34 for limitation of the mechanical free-play between the first and the second component.