Patents by Inventor Andreas Rolfs

Andreas Rolfs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleosides for suppressing or reducing the development of resistance in cytostatic therapy
    Patent number: 8492537
    Abstract: The invention relates to special nucleosides, for example, a nucleoside of the formula I, wherein R1-R5 are as described herein, and also to drugs which contain these nucleosides. Furthermore, the invention relates to the use of such nucleosides in a method for suppressing or reducing the formation of resistance in the case of cytotstatic treatment of a cancer patient.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: July 23, 2013
    Assignee: RESprotect GmbH
    Inventors: Rudolf Fahrig, Dieter Lohmann, Andreas Rolfs, Henrik Dieks, Janek Teubner, Jorg-Christian Heinrich
  • NUCLEOSIDES FOR SUPPRESSING OR REDUCING THE DEVELOPMENT OF RESISTANCE IN CYTOSTATIC THERAPY
    Publication number: 20100227834
    Abstract: The invention relates to special nucleosides, for example, a nucleoside of the formula I, wherein R1-R5 are as described herein, and also to drugs which contain these nucleosides. Furthermore, the invention relates to the use of such nucleosides in a method for suppressing or reducing the formation of resistance in the case of cytostatic treatment of a cancer patient.
    Type: Application
    Filed: August 13, 2007
    Publication date: September 9, 2010
    Applicant: RESprotech GmbH
    Inventors: Rudolf Fahrig, Dieter Lohmann, Andreas Rolfs, Henrik Dieks, Janek Teubner, Jörg-Christian Heinrich
  • 3-aminopyrroles, methods for their synthesis and for their pharmaceutical use
    Patent number: 5684160
    Abstract: The invention is directed to 3-aminopyrroles of formula I, which are largely new, to methods for the preparation and to their use as medicinal agents and preparations, as well as to anti-convulsive or analgesic preparations containing these 3-aminopyrroles.Disubstituted and monosubstituted amino groups are claimed as 3-amino substituents.The invention pursues the objective of developing largely new 3-aminopyrroles, which have CNS activity, particularly ones which anti-convulsive or analgesic properties, as well as methods for their preparation and their use as medicinal preparations.Pursuant to the invention, the synthesis is carried out by cyclizing open-chain precursors, such as aminoacrylic acid derivative, or by modifying pyrroles.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: November 4, 1997
    Assignee: Arzneimettelwerk Dresden GmbH
    Inventors: Peter Scharfenberg, Jurgen Liebscher, Alexander Knoll, Aleksej Uschmajew, Andreas Rolfs, Dieter Lohman, Gottfried Faust, Eveline Morgenstern
  • 3-aminopyrroles, methods for their synthesis and for their pharmaceutical use
    Patent number: 5502051
    Abstract: The invention is directed to 3-aminopyrroles of formula I, which are largely new, to methods for the preparation and to their use as medicinal agents and preparations, as well as to anti-convulsive or analgesic preparations containing these 3-aminopyrroles.Disubstituted and monosubstituted amino groups are claimed as 3-amino substituents.The invention pursues the objective of developing largely new 3-aminopyrroles, which have CNS activity, particularly ones which anti-convulsive or analgesic properties, as well as methods for their preparation and their use as medicinal preparations.Pursuant to the invention, the synthesis is carried out by cyclizing open-chain precursors, such as aminoacrylic acid derivative, or by modifying pyrroles.
    Type: Grant
    Filed: November 16, 1990
    Date of Patent: March 26, 1996
    Assignee: Arzneimittelwerk Dresden GmbH
    Inventors: Peter Scharfenberg, Ju/ rgen Liebscher, Alexander Knoll, Aleksej Uschmajew, Andreas Rolfs, Dieter Lohman, Gottfried Faust, Eveline Morgenstern
  • Method for producing 1-unsubstituted 3-aminopyrroles
    Patent number: 5414082
    Abstract: A process for producing pharmacologically active 1-unsubstituted 3-aminopyrroles of the formula ##STR1## by ring transformation of a corresponding 1,2-thiazolium pyrrole in a single step, without producing harmful byproducts.
    Type: Grant
    Filed: August 11, 1993
    Date of Patent: May 9, 1995
    Assignee: Arzneimittelwerk Dresden GmbH
    Inventors: Andreas Rolfs, Jurger Liebscher, Klaus Unverferth, Gottfried Faust