Abstract: The present invention provides ISVD polypeptide derivatives capable of binding coagulation Factor IX(a) and Factor X(a) which are highly potent and provide a sufficiently long half-life such to allow for effective subcutaneous—as well as peroral administration. The ISVD polypeptides derivatives disclosed herein are thus suitable for treatment of haemophilia A, haemophilia A with inhibitors and acquired haemophilia A by various routes of administration including subcutaneous and peroral administration.

Abstract: A medical system, usable for example in connection with a dialysis apparatus, may utilize radar waves for monitoring a patient, a medical area, or an object. The medical system includes at least one sending device for sending radar waves, and at least one receiving device for receiving reflected radar waves. The medical system further includes an evaluation unit for evaluating the reflected radar waves which have been received by the at least one receiving device, resulting in obtaining a result, and an output device for outputting the result or a signal based on the result.

Abstract: The invention relates to a composition for the production of CO2, the use of a composition for the production of CO2 for an insect trap, in particular for an insect trap for attracting blood-sucking insects and arthropods, and a method for the production of CO2. The composition comprises a component a), a component b), and a component c). Component a) comprises at least a first yeast strain, which has a low tolerance of less than 100 g of alcohol per liter. Component b) comprises at least one second yeast strain, which has a high tolerance of greater than 100 g of alcohol per liter. Component c) comprises at least one nutrient source for the at least one first yeast strain and/or for the at least one second yeast strain, wherein component c) is being formed by a turbo yeast or by a yeast extract.

Abstract: Disclosed is an insect repulsion and/or barrier system (10) and a method for repelling insects (2) and/or for preventing insects (2) from passing through a defined opening (12) or surface (9). The barrier system (10) is equipped with devices (16) for preventing insects from passing through an opening (12) or for repelling insects when approaching the opening (12) and/or the devices (16). The devices (16) have at least two electrodes (18), whereby different electrical potentials are applied to or can be applied to the at least two electrodes (18). The at least two electrodes (18) are arranged within or on the edge of or outside the opening such that an electrical field (28) is formed between the at least two electrodes (18). The electrical field (28) rejects and/or repels insects approaching the electrical field (28) or prevents insects approaching the electrical field (28) from passing through the opening (12).

Abstract: The invention relates to a medical system comprising an instrument, a data processing and image generating apparatus and an image display and control unit. Of these, the position acquisition apparatus is embodied to acquire a position and orientation of the instrument in relation to a reference coordinate system. The data processing and image generating apparatus is embodied to generate an image of a body part from currently recorded or stored data representing a body part, which image reproduces a view of the body part together with a representation of the position, and preferably also the orientation, of the instrument in such a way that an observer can gather the position and orientation of the instrument in the body part from the image of the body part. Here, according to the invention, the image display and control unit is wirelessly connected to the data processing and image generating apparatus, and comprises a display and input unit with a closed surface.

Abstract: The present invention relates to a process for quantitative monitoring of the composition of an oligomer/monomer mixture containing a plurality of mixture components. The process according to the invention is characterized in that the quantitative composition of the oligomer/monomer mixture is measured by means of an NIR spectroscopy measuring unit (7) under the application of a chemometric method, wherein the liquid pressure in the quantitatively monitored oligomer/monomer mixture pL>3 bar. Further, the invention relates to an apparatus for quantitative monitoring of the composition of an oligomer/monomer mixture containing a plurality of mixture components, and an installation (100) for producing a polymer product.

Abstract: A medical system comprises an instrument, a position acquisition apparatus, a data processing and image generating apparatus and an image display and control unit. The position acquisition apparatus is configured to acquire a position and orientation of the instrument in relation to a reference coordinate system. The data processing and image generating apparatus is configured to generate an image of a body part from currently recorded or stored data representing a body part, which image reproduces a view of the body part together with a representation of the position, and preferably also the orientation of the instrument so that an observer can gather the position and orientation of the instrument in the body part from the image of the body part.

Abstract: A medical system, usable for example in connection with a dialysis apparatus, may utilize radar waves for monitoring a patient, a medical area, or an object. The medical system includes at least one sending device for sending radar waves, and at least one receiving device for receiving reflected radar waves. The medical system further includes an evaluation unit for evaluating the reflected radar waves which have been received by the at least one receiving device, resulting in obtaining a result, and an output device for outputting the result or a signal based on the result.

Abstract: The invention relates to a method and to an assembly for calibrating devices 11 for detecting blood or blood components in a liquid, in particular dialysate, which devices comprise a light transmitter 17 and a light receiver 18, and an evaluation unit 20 that receives the signal from the light receiver 18 and is designed such that blood or blood components in the liquid are detected on the basis of the weakening of radiation passing through the liquid. The method according to the invention is based on the fact that the calibration of the devices 11 for detecting blood or blood components is carried out without the use of blood. The calibration is carried out using an absorption standard 30, which has predetermined optical properties in relation to the absorption of the light in blood, the absorption standard 30 being arranged in the beam path 19 between the light transmitter 17 and the light receiver 18.

Abstract: The present invention provides a frontal light diffusing device comprising a non-circular core fiber section having a proximal end and a distal end, and a lens; wherein fiber core of the non-circular core section has a “top hat” core irradiance distribution and the frontal light diffusing device provides a “top hat” spatial irradiance distribution at a targeted location. The present invention further provides a frontal light diffusing device comprising an optical fiber and a collimation lens assembly wherein the collimation lens assembly includes a variable aperture that blocks portions of light outcoupled from the optical fiber thereby allowing only a central portion of the light to exit through the variable aperture resulting in a flat irradiance distribution.

Abstract: Disclosed is an insect repulsion and/or barrier system (10) and a method for repelling insects (2) and/or for preventing insects (2) from passing through a defined opening (12) or surface (9). The barrier system (10) is equipped with devices (16) for preventing insects from passing through an opening (12) or for repelling insects when approaching the opening (12) and/or the devices (16). The devices (16) have at least two electrodes (18), whereby different electrical potentials are applied to or can be applied to the at least two electrodes (18). The at least two electrodes (18) are arranged within or on the edge of or outside the opening such that an electrical field (28) is formed between the at least two electrodes (18). The electrical field (28) rejects and/or repels insects approaching the electrical field (28) or prevents insects approaching the electrical field (28) from passing through the opening (12).

Abstract: The present invention provides a frontal light diffusing device comprising a non-circular core fiber section having a proximal end and a distal end, and a lens; wherein fiber core of the non-circular core section has a “top hat” core irradiance distribution and the frontal light diffusing device provides a “top hat” spatial irradiance distribution at a targeted location. The present invention further provides a frontal light diffusing device comprising an optical fiber and a collimation lens assembly wherein the collimation lens assembly includes a variable aperture that blocks portions of light outcoupled from the optical fiber thereby allowing only a central portion of the light to exit through the variable aperture resulting in a flat irradiance distribution.

Abstract: The present invention provides a frontal light diffusing device comprising a non-circular core fiber section having a proximal end and a distal end, and a lens; wherein fiber core of the non-circular core section has a “top hat” core irradiance distribution and the frontal light diffusing device provides a “top hat” spatial irradiance distribution at a targeted location. The present invention further provides a frontal light diffusing device comprising an optical fiber and a collimation lens assembly wherein the collimation lens assembly includes a variable aperture that blocks portions of light outcoupled from the optical fiber thereby allowing only a central portion of the light to exit through the variable aperture resulting in a flat irradiance distribution.

Abstract: The invention relates to a method and to an assembly for calibrating devices 11 for detecting blood or blood components in a liquid, in particular dialysate, which devices comprise a light transmitter 17 and a light receiver 18, and an evaluation unit 20 that receives the signal from the light receiver 18 and is designed such that blood or blood components in the liquid are detected on the basis of the weakening of radiation passing through the liquid. The method according to the invention is based on the fact that the calibration of the devices 11 for detecting blood or blood components is carried out without the use of blood. The calibration is carried out using an absorption standard 30, which has predetermined optical properties in relation to the absorption of the light in blood, the absorption standard 30 being arranged in the beam path 19 between the light transmitter 17 and the light receiver 18.

Abstract: The present invention provides a diffuser light blocking device comprising an end cap member (820) having a pocketing feature (821) that has a side wall (822) and an end reflective surface (810); the pocketing feature's shape corresponds to exterior shape of distal portion (830) of a diffuser (800) having a distal end surface (801); the pocketing feature engages the distal portion; an overlapping section (815) of the pocketing feature's side wall surrounds the distal portion's side wall (802) and prevents at least 95% of the light output from the distal portion from escaping out of the distal portion's side wall; the end reflective surface blocks any forward propagating light output from the distal end surface and returns at least 80% of light coming out of the distal end surface back towards the diffuser; the end cap member is thermally conductive; the end cap member's length (831) and diameter (832) provide an exterior surface area that is at least 1,000% of the surface area of the distal end surface; and t

Abstract: The present invention provides a cylindrical light diffusing device comprising a non-circular core fiber having (i) a fiber core that provides a “top hat” core irradiance distribution; (ii) light blocking means that prevent frontal light emisson from distal end of the non-circular core fiber; and (iii) a light diffusing section having a diffusing proximal end, a diffusing distal end, and internal scattering features distributed within the fiber core of the light diffusing section along central axis of the fiber core, wherein the light diffusion section emits irradiance in a radially symmetric longitudinally “top hat” diffusing irradiance distribution.

Abstract: An optical plug connector device includes at least one lens array and at least one fiber holder, which is designed to position end regions of a plurality of optical fibers relative to the lens array, and which has at least one first fiber holding element wherein the fiber holder comprises at least one second fiber holding element having a higher manufacturing precision than the first fiber holding element.

Abstract: The present invention provides a diffuser light blocking device comprising an end cap member (820) having a pocketing feature (821) that has a side wall (822) and an end reflective surface (810); the pocketing feature's shape corresponds to exterior shape of distal portion (830) of a diffuser (800) having a distal end surface (801); the pocketing feature engages the distal portion; an overlapping section (815) of the pocketing feature's side wall surrounds the distal portion's side wall (802) and prevents at least 95% of the light output from the distal portion from escaping out of the to distal portion's side wall; the end reflective surface blocks any forward propagating light output from the distal end surface and returns at least 80% of light coming out of the distal end surface back towards the diffuser; the end cap member is thermally conductive; the end cap member's length (831) and diameter (832) provide an exterior surface area that is at least 1,000% of the surface area of the distal end surface; an

Abstract: The present invention provides a frontal light diffusing device comprising a non-circular core fiber section having a proximal end and a distal end, and a lens; wherein fiber core of the non-circular core section has a “top hat” core irradiance distribution and the frontal light diffusing device provides a “top hat” spatial irradiance distribution at a targeted location. The present invention further provides a frontal light diffusing device comprising an optical fiber and a collimation lens assembly wherein the collimation lens assembly includes a variable aperture that blocks portions of light outcoupled from the optical fiber thereby allowing only a central portion of the light to exit through the variable aperture resulting in a flat irradiance distribution.

Abstract: The present invention provides a cylindrical light diffusing device comprising a non-circular core fiber having (i) a fiber core that provides a “top hat” core irradiance distribution; (ii) light blocking means that prevent frontal light emisson from distal end of the non-circular core fiber; and (iii) a light diffusing section having a diffusing proximal end, a diffusing distal end, and internal scattering features distributed within the fiber core of the light diffusing section along central axis of the fiber core, wherein the light diffusion section emits irradiance in a radially symmetric longitudinally “top hat” diffusing irradiance distribution.