Patents by Inventor Andreas Schirmer

Andreas Schirmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof
    Publication number: 20040077058
    Abstract: The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides that encode such enzymes, and to host cells in which such encoding polynucleotides can be advantageously expressed.
    Type: Application
    Filed: June 13, 2003
    Publication date: April 22, 2004
    Inventors: Richard C. Hutchinson, Ralph C. Reid, Zhihao Hu, Andreas Rascher, Andreas Schirmer, Robert McDaniel
  • Polyketide derivatives
    Patent number: 6624302
    Abstract: The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use. The compounds of the present invention are cyclic polyketides (also referred to as a “macrolides” or “macrolactones”) that include as part of their structure and bind to a FK binding protein wherein R4 and R5 are each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of R4 and R5 is hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs.
    Type: Grant
    Filed: December 27, 2002
    Date of Patent: September 23, 2003
    Assignee: Kosan Biosciences, Inc.
    Inventors: Daniel Chu, Maria Fardis, Chaitan Khosla, Christopher Reeves, Daniel Santi, Andreas Schirmer
  • Novel polyketide derivatives
    Publication number: 20030144315
    Abstract: The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use.
    Type: Application
    Filed: December 27, 2002
    Publication date: July 31, 2003
    Inventors: Daniel Chu, Maria Fardis, Chaitan Khosla, Christopher Reeves, Daniel Santi, Andreas Schirmer
  • Polyketide derivatives
    Patent number: 6569867
    Abstract: The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use. The compounds of the present invention are cyclic polyketides (also referred to as a “macrolides” or “macrolactones”) that include as part of their structure and bind to a FK binding protein wherein R4 and R5 are each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of R4 and R5 is hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: May 27, 2003
    Assignee: Kosan Biosciences, Inc.
    Inventors: Daniel Chu, Maria Fardis, Chaitan Khosla, Christopher Reeves, Daniel Santi, Andreas Schirmer
  • Novel polyketide derivatives
    Publication number: 20020183348
    Abstract: The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use.
    Type: Application
    Filed: April 12, 2002
    Publication date: December 5, 2002
    Inventors: Daniel Chu, Maria Fardis, Chaitan Khosla, Christopher Reeves, Daniel Santi, Andreas Schirmer
  • Novel polyketide derivatives
    Publication number: 20020065295
    Abstract: The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use.
    Type: Application
    Filed: May 10, 2001
    Publication date: May 30, 2002
    Inventors: Daniel Chu, Maria Fardis, Chaitan Khosla, Christopher Reeves, Daniel Santi, Andreas Schirmer