Abstract: Embodiments of the present invention provide a memristor having a first electrode, a second electrode and a memristive layer arranged between the first electrode and the second electrode. Thereby, the memristor is adapted to obtain an asymmetrical current density distribution in the memristive layer.

Abstract: The present invention relates to a method for producing a structure modeled on a biological tissue. The invention also relates to a structure which can be produced using the method according to the invention. According to an embodiment of the invention, a precursor of a biopolymer is locally irradiated with electromagnetic radiation in a targeted manner, wherein the irradiation, in particular the selection of the areas to be irradiated, is effected according to data which describe a structural construction at least components of the extracellular matrix of the biological tissue. In this case, the electromagnetic radiation is such that two-photon or multi-photon absorption takes place in the irradiated areas of the precursor and results in the precursor being polymerized to form the biopolymer in the irradiated areas, with the result being that the precursor is at least partially solidified there.

Abstract: Embodiments of the present invention provide a memristor having a first electrode, a second electrode and a memristive layer arranged between the first electrode and the second electrode. Thereby, the memristor is adapted to obtain an asymmetrical current density distribution in the memristive layer.

Abstract: The present invention relates to a device for closing an open, bleeding wound of an animal or human body. The invention further relates to a device for processing tissue of a human or animal body, for example, a device for producing a support in a vessel of the body. The device for closing a bleeding wound firstly comprises a laser for irradiating the blood in the wound with infrared laser radiation. According to the invention, the laser radiation of the laser can be adjusted such that two- or multiphoton absorption occurs in irradiated regions of the blood, whereby the blood in the irradiated regions polymerises into a solidified biopolymer and closes the wound.

Abstract: A method is provided for producing a microstructured molded object that is intended for culturing of biological cells. According to this method, a plastically deformable first porous film is prepared, as well as a deformable second film and a deformable sacrificial film. The first, second and sacrificial film are placed in a stack. Next, the sacrificial film is subjected to pressure to press the stack into a mold. The mold has recesses, such that deformed regions in the form of cavities are produced in the sacrificial film, the first film and the second film, and undeformed regions remain. During the pressing of the film stack into the mold, the first film and the second film are joined to each other, so that they form a composite film. At least portions of the deformed regions of the second film are etched so that sections of the second film are chemically dissolved.

Abstract: A microstructured composite component is provided including structures for carrying out fluid processes. A device is provided for producing microstructured composite components. A method provided includes a first step during which a first film is arranged above a second film between first and second mold parts. The first and/or second mold parts have microstructured cavities to be filled. In a second step, the first and second mold parts are heated in at least one region in which they contact one of the films. An excess pressure is then produced between the first film and the second film to force the first and/or second films into the cavities. In a further step, the first and second mold parts are pressed together by a pressing force. Once the first mold part, the second mold part, the first film and the second film are cooled, they form a microstrutured composite component.

Abstract: A method is provided for producing a microstructured molded object that is intended for culturing of biological cells. According to this method, a plastically deformable first porous film is prepared, as well as a deformable second film and a deformable sacrificial film. The first, second and sacrificial film are placed in a stack. Next, the sacrificial film is subjected to pressure to press the stack into a mold. The mold has recesses, such that deformed regions in the form of cavities are produced in the sacrificial film, the first film and the second film, and undeformed regions remain. During the pressing of the film stack into the mold, the first film and the second film are joined to each other, so that they form a composite film. At least portions of the deformed regions of the second film are etched so that sections of the second film are chemically dissolved.

Abstract: The present invention relates to a method for producing a structure modeled on a biological tissue. The invention also relates to a structure which can be produced using the method according to the invention. According to an embodiment of the invention, a precursor of a biopolymer is locally irradiated with electromagnetic radiation in a targeted manner, wherein the irradiation, in particular the selection of the areas to be irradiated, is effected according to data which describe a structural construction at least components of the extracellular matrix of the biological tissue. In this case, the electromagnetic radiation is such that two-photon or multi-photon absorption takes place in the irradiated areas of the precursor and results in the precursor being polymerized to form the biopolymer in the irradiated areas, with the result being that the precursor is at least partially solidified there.

Abstract: The invention relates to a hybrid three-dimensional sensor array, in particular for measuring biological cell assemblies. The sensor array has a plurality of microstructured sensor plates, each having one carrier section on which a plurality of sensor needles are arranged in a comb-like manner, which carry a plurality of electrode surfaces. Furthermore, a plurality of spacer elements are provided, which are fastened between the sensor plates so that both the carrier sections and the sensor needles of adjacent sensor plates are at a distance from each other. The invention further relates to a measuring assembly for measuring electrical activities of biological cell assemblies using such a sensor array.

Abstract: A microstructured composite component is provided including structures for carrying out fluid processes. A device is provided for producing microstructured composite components. A method provided includes a first step during which a first film is arranged above a second film between first and second mold parts. The first and/or second mold parts have microstructured cavities to be filled. In a second step, the first and second mold parts are heated in at least one region in which they contact one of the films. An excess pressure is then produced between the first film and the second film to force the first and/or second films into the cavities. In a further step, the first and second mold parts are pressed together by a pressing force. Once the first mold part, the second mold part, the first film and the second film are cooled, they form a microstrutured composite component.

Abstract: The invention relates to a device for generating and/or arranging sequences of a fluid sample in a carrier fluid. The invention comprises a microchannel having an inlet, an outlet and a nozzle opening therebetween leading into the microchannel. The invention further relates to a delivery unit, which pumps in the carrier fluid using a feed volume flow and suctions off the carrier fluid using a discharge volume flow. In a sample container, the nozzle opening is in contact with the fluid sample. By means of a control unit, the ratio between feed volume flow and discharge volume flow is varied. The cross-section of the nozzle opening is selected such that no carrier medium exits from the nozzle opening when the feed volume flow equals the discharge volume flow and that a fluid sample enters the nozzle opening when the discharge volume flow is greater than the feed volume flow. The invention further relates to a method for generating and/or arranging sequences of a fluid sample in a carrier fluid.

Abstract: The present invention relates to a microbioreactor comprising a sample support (7) for holding cells; a bypass (3) with a capillary opening for feeding test reagent and/or for aeration and ventilation of the microbioreactor; a pump module (5) for perfusion of the microbioreactor with test reagent and/or gas feeding and purging of the microbioreactor; a transparent viewing window (2); and fluid channels (4) that form a circuit. The invention further relates to a bioreactor-microtiter plate comprising a plurality of such microbioreactors.

Abstract: The invention relates to a partially active microfluidic system for cell cultivation comprising a multiwell system (4) with multiple wells (17) and cavities formed therein that hold cells. Each cavity (11) is formed by at least one inlay (3) comprising an opening (1) that does not open up directly into the cavity (11), but rather into a space (17) surrounding the cavity, wherein the medium present in the surrounding space communicates with the medium contained in the cavity (11) by way of a sieve structure in the inlay. The invention is suitable in particular for 3D cell cultivation.

Abstract: Microwells, which are open on both sides and are arranged two-dimensionally in a microwell matrix (4), are hermetically closed by pressure on both sides using plugs (6) covered with a sealing sheet (11). A layer of elastic material (9), which is arranged between the plug (6) and the sealing sheet (11), guarantees uniform pressure on all the microwells of a microwell matrix (4) which is loosely held by a frame structure (1). Continuous peripheral elevations (2), which protrude in both directions at right angles to the plane of the microwell matrix (4), ensure that the deformable thin layer of elastic material (9) does not escape sideways between the plug (6) and the microwell matrix (4) during the pressing process. A plurality of microwell matrices (4) are held simultaneously by the frame structure (1) and are hermetically closed by a corresponding number of allocated plugs (6), which are fastened to a base plate (7) and a cover plate (8), respectively.

Abstract: The invention relates to a device for controlling the amount of liquid substances received and discharged. It is an object of the invention to produce a device, enabling a plurality of different liquid substances to be received and discharged from micro or nano titer plates. According to the invention, it is possible to carry out one or more chemical or biological reactions in said device and to receive liquid substances with differing viscosity, as a result of capillary channels which are arranged at an equal distance from each other and are provided in a row, said channels being brought together in a communicative link with a chamber which is can be impinged upon by overpressure and underpressure, whereby the capillary channels are embedded in the plate and one sieve-type membrane is associated with the ends of the capillary channels at least on the inner side of the pressure chamber. According to the invention, an area is provided above each end of the capillary channels for receiving a liquid substance.

Abstract: The invention relates to microspheres with a narrow distribution of particle size and a uniform spherical shape, consisting of a partially or completely cross-linked polymer material. The invention also relates to a method for producing said microspheres and to the use thereof.

Abstract: A device for carrying out the parallel incubation of solutions comprises a holding frame (1) inside of which one or more titer plates (2) can be placed. Each titer plate (2) is separately closed by a cover plate (4), which can be pressed thereon, resulting in the prevention of unwanted evaporation effects and transport phenomena. Seals (5) are placed between the cover plate (4) and the holding frame (1). Continuous recesses in the holding frame (1) are located underneath the titer plates (2) and are occluded by a common one-piece bottom plate (7) having punch-like protrusions (6). Devices for regulating temperature can be arranged both inside the cover plate (4), the holding frame (1) as well as inside the one-piece bottom plate (7). The holding frame (1) comprises channel-like recesses for accommodating liquid solvent.

Abstract: The invention relates to a method and functional particles for carrying out chemical or biological reactions or syntheses. The aim of the invention is to provide a solution ensuring complete compatibility between micro and macroscales, whereby a large variety of coupling reactions can be carried out, and a clear allocation of the reaction or synthesis products to the individual functional particles is ensured, entailing little effort. In order to achieve this, x charges of functional particles are provided for n reaction solutions, x being equal to or less than n, the density of said particles being variably determined in such a way that they can be separated according to the density thereof even when being charged with the complete reaction or synthesis product.

Abstract: Microwells, which are open on both sides and are arranged two-dimensionally in a microwell matrix (4), are hermetically closed by pressure on both sides using plugs (6) covered with a sealing sheet (11). A layer of elastic material (9), which is arranged between the plug (6) and the sealing sheet (11), guarantees uniform pressure on all the microwells of a microwell matrix (4) which is loosely held by a frame structure (1). Continuous peripheral elevations (2), which protrude in both directions at right angles to the plane of the microwell matrix (4), ensure that the deformable thin layer of elastic material (9) does not escape sideways between the plug (6) and the microwell matrix (4) during the pressing process. A plurality of microwell matrices (4) are held simultaneously by the frame structure (1) and are hermetically closed by a corresponding number of allocated plugs (6), which are fastened to a base plate (7) and a cover plate (8), respectively.

Abstract: When chemical substances are pipetted in individual microwells of a microwell array (4), problematic evaporation effects arise concerning the solvent with which the microwells are already filled. In order to prevent such undesired evaporation effects, a pipetting device for the automated pipetting of chemical substances having a holder (3), which receives at least one microwell array (4), and a pipetting head (11), which is fitted in such a way that it can be moved, is designed with the pipetting head (11) being fastened, by means of a holding device, to a plate (7) which follows the movements of the pipetting head (11) during the pipetting process. The plate (7) forms above the microwell array (4), in conjunction with a frame (5) tightly enclosing the microwell array (4), a sealed gas space (14) into which the pipetting head (11) protrudes through a matched hole (13) in the plate (7).