Abstract: The present invention relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to a therapeutic combination which comprises a PD-1 antagonist, an ATR inhibitor and a platinating agent.

Abstract: The present invention relates to a double-face adhesive tape that can be removed by twisting, prying or peeling off from, e.g., a wall without leaving residues. The present invention also relates to a method for the concealed mounting on and residue-free and non-destructive removal of objects from a sensitive substrate, wherein the object is affixed to the sensitive substrate by means of the double-face adhesive tape and, as and when necessary, is removed by twisting or prying or peeling.

Abstract: The invention relates to a method for checking the silanization of pale-colored fillers, where a mixture comprising at least one silanized pale-colored filler, preferably silanized silica, and comprising at least one rubber is irradiated with ultrasound waves in a frequency range of 4 to 10 MHz, preferably of 5 to 7 MHz, and the signal strength of the ultrasound waves is determined after transmission through the rubber mixture, where the relative attenuation coefficient ?rel of the rubber mixture in the frequency range of the ultrasound waves is determined, the standard deviation ? of the relative attenuation coefficient ?rel is determined, and ?rel and ? are used for detection of incipient crosslinking of the rubber mixture.

Abstract: The present invention relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to a therapeutic combination which comprises an anti-PD-L antibody and a DNA-PK inhibitor, optionally together with one or more additional chemotherapeutic agents or radiotherapy. The therapeutic combination is particularly intended for use in treating a subject having a cancer that tests positive for PD-L1 expression.

Abstract: Disclosed herein are composite materials and methods for forming the same. In one embodiment, a composite material comprises a primer layer comprising a polyalkylenimine, and an active layer comprising a binder and a metal organic framework (MOF), wherein the MOF comprises a bidentate organic compound coordinated to a metal ion, and wherein the active layer forms a coating on the primer layer.

Abstract: The invention relates to a method for checking the silanization of pale-colored fillers, where a mixture comprising at least one silanized pale-colored filler, preferably silanized silica, and comprising at least one rubber is irradiated with ultrasound waves in a frequency range of 4 to 10 MHz, preferably of 5 to 7 MHz, and the signal strength of the ultrasound waves is determined after transmission through the rubber mixture, where the relative attenuation coefficient ?rel of the rubber mixture in the frequency range of the ultrasound waves is determined, the standard deviation ? of the relative attenuation coefficient ?rel is determined, and ?rel and ? are used for detection of incipient crosslinking of the rubber mixture.

Abstract: The present invention relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to a therapeutic combination which comprises a PD-1 antagonist, an ATR inhibitor and a platinating agent.

Abstract: The invention relates to a method of testing silanization, which permits inline control of the in situ silanization of light-colored fillers, especially precipitated silicas. This enables continuous in situ silanization in the production of rubber mixtures comprising silanized light-colored fillers, and representative control of the rubber mixture under production conditions. The process is additionally nondestructive and has a high tolerance for carbon black as an additional constituent of the rubber mixture.

Abstract: The present invention relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to a therapeutic combination which comprises an anti-PD-L antibody and a DNA-PK inhibitor, optionally together with one or more additional chemotherapeutic agents or radiotherapy. The therapeutic combination is particularly intended for use in treating a subject having a cancer that tests positive for PD-L1 expression.

Abstract: Disclosed herein are composite materials and methods for forming the same. In one embodiment, a composite material comprises a primer layer comprising a polyalkylenimine, and an active layer comprising a binder and a metal organic framework (MOF), wherein the MOF comprises a bidentate organic compound coordinated to a metal ion, and wherein the active layer forms a coating on the primer layer.

Abstract: The invention relates to a method of testing silanization, which permits inline control of the in situ silanization of light-colored fillers, especially precipitated silicas. This enables continuous in situ silanization in the production of rubber mixtures comprising silanized light-colored fillers, and representative control of the rubber mixture under production conditions. The process is additionally nondestructive and has a high tolerance for carbon black as an additional constituent of the rubber mixture.

Abstract: The invention relates to novel processes for determining the quality of an uncrosslinked rubber mixture by means of ultrasound and to an apparatus suitable for this purpose.

Abstract: For determining a changing spatial distribution of particles at each of multiple points in time, real two-dimensional images of the particles are recorded with different mapping functions. An estimated spatial distribution of the particles is provided. Virtual two-dimensional images of the estimated spatial distribution are calculated applying the different mapping functions. Differences between the virtual and the real two-dimensional images are determined; and the estimated spatial distribution of the particles are varied for reducing the differences to obtain a spatial distribution approximated to the actual spatial distribution of the particles. The estimated spatial distribution of the particles is provided in that the locations of the individual particles in a spatial distribution approximated for one other point in time are shifted dependently on how the locations of the individual particles have changed between at least two spatial distributions approximated for at least two other points in time.

Abstract: The invention relates to novel batches of cross-linking agents, containing marking substances, to novel cross-linkable rubber mixtures, to a method for the production thereof and to the use of same.

Abstract: For determining a changing spatial distribution of particles at each of multiple points in time, real two-dimensional images of the particles are recorded with different mapping functions. An estimated spatial distribution of the particles is provided. Virtual two-dimensional images of the estimated spatial distribution are calculated applying the different mapping functions. Differences between the virtual and the real two-dimensional images are determined; and the estimated spatial distribution of the particles are varied for reducing the differences to obtain a spatial distribution approximated to the actual spatial distribution of the particles. The estimated spatial distribution of the particles is provided in that the locations of the individual particles in a spatial distribution approximated for one other point in time are shifted dependently on how the locations of the individual particles have changed between at least two spatial distributions approximated for at least two other points in time.

Abstract: The invention is directed to the treatment of lung cancer, preferably non-small cell lung cancer (NSCLC) by means of a combination therapy comprising concurrent chemo-radiotherapy followed by vaccination with a muc-1 lipopetide. The therapy elicits prolonged survival rates compared to a respective therapy including sequential chemo-radiotherapy.

Abstract: The present invention provides a method and a system for determining forces which act on a body with a controlled volume which is provided inside the flow tunnel and in which the body is arranged. A first measuring means is used to measure a pressure distribution for each surface defining the controlled volume. A second measuring means measures a velocity field for each defining surface of the controlled volume. Furthermore, a calculation unit is provided for calculating the forces acting on the body as a function of the pressure distributions and velocity fields measured for the defining surfaces of the controlled volume.

Abstract: The invention relates to novel processes for determining the quality of an uncrosslinked rubber mixture by means of ultrasound and to an apparatus suitable for this purpose.

Abstract: The invention relates to novel batches of cross-linking agents, containing marking substances, to novel cross-linkable rubber mixtures, to a method for the production thereof and to the use of same.

Abstract: Disclosed is a method for determining the quality, expressed in terms of a quality value, of an biomolecule sample, based on measured data of the biomolecule sample, by extracting a number of prescribed features from the measured data using data analysis, and determining the quality value from the extracted features using a quality algorithm.