Abstract: A sieve box for the particle separation process is composed of a box with a pan, a mesh covering, and at least one cleaning device. The cleaning device serves a dual purpose brushes or knobs bounce against the mesh covering while the leg portion continually moves particulate in the pan.

Abstract: A circuit breaker for multi-phase power includes an opening-closing apparatus configured to open and close each phase of the multiphase power, a detection unit configured to detect a fault current in at least one phase of an electrical installation, a plurality of connecting bars disposed on a load side of the circuit breaker, and a fastening device disposed on the connecting bars and configured to detachably fasten a short circuiter to the connecting bars, the short circuiter configured to create a short circuit between the connecting bars when a fault is detected by the detection unit. The option proposed according to the invention of installing a short circuiter means that the circuit breaker is fully operational, either with or without the installation of a short circuiter.

Abstract: A circuit breaker for multi-phase power includes an opening-closing apparatus configured to open and close each phase of the multiphase power, a detection unit configured to detect a fault current in at least one phase of an electrical installation being protected by the circuit breaker, a plurality of connecting bars disposed on a load side of the circuit breaker, and a short circuiter disposed on the connecting bars and configured to produce a short circuit between the connecting bars if a fault current is detected by the fault-current detection unit. When a fault current occurs, a tripping signal can be transmitted by the detection system to the short circuiter. The circuit breaker is also fully operational, even without a function-activated short circuiter.

Abstract: Process for the preparation of tetrahydrobiopterin from neopterin and/or 6-substituted pterins with an improved yield and a high stereoselectivity. Also disclosed herein are novel individual intermediates prepared in the preparation of tetrahydrobiopterin, such as selectively protected neopterin useful for the preparation of tetrahydrobiopterin.

Abstract: The present invention relates to angiogenesis inhibitors, in particular receptor tyrosine kinase inhibitors, and their use for the treatment of hyperproliferative diseases, angiogenesis and disorders depending on angiogenesis such as tumour forming cancers. It also relates to a method of inhibiting angiogenesis or treating a vascular anomaly in a mammal comprising administering to the mammal an amount of an Eph receptor inhibitor which is effective for inhibiting angiogenesis or for treating the vascular anomaly in the mammal. Further, the present invention relates to the use of compounds for the treatment of angiogenesis related disorders involving a protein kinase, preferably a tyrosine kinase, and to some specific forms of said compounds as a medicament. Compounds useful in the practice of the invention have the general formula I wherein R1, R2, R3, R4 and R5 are as defined in the specification.

Abstract: The invention relates to antibacterial amide macrocycles, to methods for the production thereof, and to the use of the same for producing pharmaceuticals for the treatment and/or prophylaxis of illness, especially bacterial infections.

Abstract: The invention relates a planar optical circuit having at least one functional layer with structures for guidance, changing, regulation, control, production and/or detection of optical signals, a carrier substrate on which the at least one functional layer is formed, and at least two physically separate functional units which are formed in the at least one functional layer on the carrier substrate. According to the invention, the at least two functional units (2, 3) are thermally separated from one another by at least one trench structure (4) in the functional layer (11) and/or in the carrier substrate (11).

Abstract: The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Abstract: The invention relates to antibacterial ester macrocycles of formula (I), methods for the production thereof, and the use thereof for producing medicaments used for the treatment and/or prophylaxis of diseases, particularly bacterial infections.

Abstract: This application relates to isotopically labeled affinity markers of the formula (II) for mass spectrometric analysis of proteins. In formula (II), the groups A, PRG, S, Z, L', Z', R, R', k, l, m, and n are as defined in the claims. The application also provides a process for preparing these materials, a method for analyzing proteins using such materials, and a kit containing one or more of these materials.

Abstract: The invention relates to antibacterial amide macrocycles and process for their preparation, their use for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially of bacterial infections.

Abstract: The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions comprising them, and their use in the treatment of diseases in humans or animals.

Abstract: The invention relates to a method for producing an optical arrangement (10, 300), in which an optical component (355, 20) is optically connected to at least one waveguide (90, 320, 330) provided on or in a carrier substrate (100, 310). In order to enable an optical component to be connected to an optical waveguide of a carrier substrate in a particularly simple and thus cost-effective manner, the invention provides for there to be arranged between the optical component (20, 355) and the waveguide (90, 320, 330) an adjustment device (40, 350) with at least one auxiliary waveguide (60, 410, 440), the waveguide ends (50, 70, 400, 420, 430, 450) of which are in each case movable and an optical adjustment between the optical component (20, 355) and the waveguide (90, 320, 330) of the carrier substrate (100, 310) is effected by a mechanical adjustment of the movable waveguide ends (50, 70, 400, 420, 430, 450).

Abstract: The invention concerns isotopically coded affinity markers (ICAT) for mass spectrometric analysis of proteins, and the preparation and use if said markers.

Abstract: A planar optical circuit has at least one functional layer with structures for guidance, changing, regulation, control, production and/or detection of optical signals, a carrier substrate on which the functional layer is formed, and at least two physically separate functional units that are formed in the functional layer on the carrier substrate. The two functional units are thermally separated from one another by at least one trench structure disposed in the functional layer and/or in the carrier substrate.

Abstract: An electric power distribution switching device including a detector for detecting accidental arcs in the electric power distribution switching device, which detector includes at least one waveguide in which the light generated by the arc and reaching it via its casing is used as a triggering or warning criterion. The detector can include a support rod, a waveguide wound helically around the support rod, and two plug connectors fitted at the ends of the support rod. The detector also includes a heat-shrink sleeve which is permeable to light and UV radiation. The heat-shrink sleeve is fitted over the support rod, the waveguide and the plug connectors. A detector configured in this manner can prevent damage to the detector during installation or fitting in the switching equipment.