Abstract: The disclosure relates to monitoring a state of a physical passenger transport system. In an aspect, monitoring includes use of an updated digital double dataset that reproduces characterizing properties of components of the physical passenger transport system in an actual configuration of the passenger transport system after assembly and installation thereof in a building, in a machine-processable manner. At least one detection device is arranged in the physical passenger transport system, which detects a load profile which is transmitted to the updated digital double dataset. A set of rules is used to convert the load profile into modified characterizing properties of virtual components. Through the monitoring, changes and change trends on the components are tracked and evaluated using the updated digital double dataset by calculations and/or by static and dynamic simulations.

Abstract: A coupling device for a fluid cooling system may have a first coupling unit having a first housing, which has a first sub-housing and a second sub-housing connectable to the first sub-housing. The first sub-housing may have a first axial passage opening connectable to a first fluid line, a first signal interface and a first end face. The second sub-housing may have a second axial passage opening connectable to a second fluid line, a second signal interface and a second end face. The first sub-housing and the second sub-housing are axially connectable to one another and the passage openings are fluidically connected to one another and the signal interfaces are connected to one another. The two sub-housings may be laterally connectable to one another, so that in the laterally coupled state, the two sub-housings are arranged parallel next to one another.

Abstract: The invention relates to a method for selecting an expressed sequence from a library, comprising the following steps: Each of a plurality of eukaryotic cells comprising a cell wall comprises a nucleic acid sequence member of a library, which is expressed as a target membrane protein in said eukaryotic cells. The cell wall of the cells is permeabilized. The penneabilized cells are labeled with a ligand capable of binding to the target membrane protein. The ligand bears a detectable label. A subset of the labelled cells is selected as a function of detectable label present. Finally, an expressed nucleic acid sequence is isolated from said selection of cells in an isolation step.

Abstract: A coupling device for a fluid cooling system may have a first coupling unit having a first housing, which has a first sub-housing and a second sub-housing connectable to the first sub-housing. The first sub-housing may have a first axial passage opening connectable to a first fluid line, a first signal interface and a first end face. The second sub-housing may have a second axial passage opening connectable to a second fluid line, a second signal interface and a second end face. The first sub-housing and the second sub-housing are axially connectable to one another and the passage openings are fluidically connected to one another and the signal interfaces are connected to one another. The two sub-housings may be laterally connectable to one another, so that in the laterally coupled state, the two sub-housings are arranged parallel next to one another.

Abstract: A method for creating a data backup of a virtualized automation solution running on a virtualization server is provided. A computer program having at least one program code instruction with a specification of data and files to be included in the data backup is executed on the virtualization server based on a call from a remote computer, and the data backup is created as part of the execution of the computer program. A hypervisor is executed on the virtualization server. The computer program includes program code instructions that prompt the hypervisor, prior to the creation of the data backup, to write the configuration files thereof to a boot medium of the hypervisor that is detected by the data backup.

Abstract: A method for creating a data backup of a virtualized automation solution running on a virtualization server is provided. A computer program having at least one program code instruction with a specification of data and files to be included in the data backup is executed on the virtualization server based on a call from a remote computer, and the data backup is created as part of the execution of the computer program. A hypervisor is executed on the virtualization server. The computer program includes program code instructions that prompt the hypervisor, prior to the creation of the data backup, to write the configuration files thereof to a boot medium of the hypervisor that is detected by the data backup.

Abstract: A hydrant has a riser pipe and a shut-off element which can be brought from at least one open position into at least one closed position and vice versa. The shut-off element in the closed position seals the interior of the riser pipe from a hydrant inlet. The hydrant comprises at least one first passage, by which the interior can be fluidically connected to the outside of the hydrant, and one second passage, by which the pressurized hydrant inlet can be fluidically connected to the outside of the hydrant, wherein the first passage and the second passage can be brought into operative connection with each other. The operative connection produces a vacuum by water flowing through the second passage such that water in the interior of the riser pipe is led away via the first passage and the riser pipe is thereby drained.

Abstract: A hydrant has a riser pipe and a shut-off element which can be brought from at least one open position into at least one closed position and vice versa. The shut-off element in the closed position seals the interior of the riser pipe from a hydrant inlet. The hydrant comprises at least one first passage, by which the interior can be fluidically connected to the outside of the hydrant, and one second passage, by which the pressurized hydrant inlet can be fluidically connected to the outside of the hydrant, wherein the first passage and the second passage can be brought into operative connection with each other. The operative connection produces a vacuum by water flowing through the second passage such that water in the interior of the riser pipe is led away via the first passage and the riser pipe is thereby drained.

Abstract: A portable drug administration device includes a pump and a controller configured to control operation of the pump according to a standard administration mode and a suspend mode in which drug administration is temporarily suspended. The device is configured to generate an event trigger on the occurrence of at least one of an error condition and/or the beginning of a maintenance action by the user. The controller is configured to detect the occurrence of the event trigger, and to store, in response to the event trigger, administration data, the administration data comprising all information that characterizes the current administration according at the time of occurrence of the event trigger automatically in a memory and to switch the device from the standard administration mode to the suspend mode.

Abstract: The present invention relates to a method of coating of a device, preferably implants, with a substance comprising the steps of (a) contacting said device into a solution of said substrate or substance, and (b) drying said device while being submerged in said solution. The present invention also relates to a packaging container for a device, preferably an implant. Said packaging container being adapted such that said device is coatable within said packaging container. Moreover, the present invention relates to a method of coating the inner surfaces of a packaging container for a device, preferably implants, to be coated by a substance, comprising the steps of (a) siliconizing said inner surfaces of said container using a silicone emulsion, and (b) heat-curing to form a baked-in silicone layer on said inner surfaces of said container.

Abstract: A portable drug administration device includes a pump and a controller configured to control operation of the pump according to a standard administration mode and a suspend mode in which drug administration is temporarily suspended. The device is configured to generate an event trigger on the occurrence of at least one of an error condition and/or the beginning of a maintenance action by the user. The controller is configured to detect the occurrence of the event trigger, and to store, in response to the event trigger, administration data, the administration data comprising all information that characterizes the current administration according at the time of occurrence of the event trigger automatically in a memory and to switch the device from the standard administration mode to the suspend mode.

Abstract: The present invention relates to a material having osteoinductive and osteoconductive properties in vivo comprising a ceramic carrier, preferably containing calcium phosphate, and an active agent, preferably an osteoinductive protein/peptide or a drug, and a polymer, wherein the active agent is homogeneously coated on the carrier and within the polymer, which is preferably a degradable polymer. Said polymer modulates the release kinetic of the active agent and protects same from degradation to prolong the half-life in vivo. Moreover, the present invention relates to a method for the production of a material having osteoinductive and osteoconductive properties in vivo.

Abstract: An in-situ-hardening paste, containing an organic or inorganic filling material, a biodegradable polymer and a water soluble polymeric plasticizer was developed as a delivery system for an active agent with scaffold properties in the field of tissue regeneration. The hardened paste is sufficient mechanical stable to can be used as bone and cartilage replacement matrix. All components are full biocompatible, preferably bioresorbable and certified for parenteral application. The sustained release of peptides and proteins can be modulated by the composition and process design. The invention encompasses a pharmaceutical composition comprising the paste of the invention and relates to the use of said paste for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation.

Abstract: A hypodermic syringe has a hollow body adapted to hold a liquid, an inner cap fitted over an end of the body, and an axially extending needle seated in the inner cap and having an outer point projecting axially outward from the inner cap and an inner point projecting axially inward from the inner cap toward the body. An outer cap fittable over the inner cap and needle is connected to a clamp ring engageable around the inner cap by a frangible web. Interengaging formations on the ring and on the inner cap releasably retain the outer cap in an outer position spaced axially outward of the body and in which an interior of the outer cap is open to the exterior and an inner position spaced axially closely to the body and in which the interior of the outer cap is not open to the exterior.

Abstract: The present invention relates to a method of coating of a device, preferably implants, with a substance comprising the steps of (a) contacting said device into a solution of said substrate or substance, and (b) drying said device while being submerged in said solution. The present invention also relates to a packaging container for a device, preferably an implant. Said packaging container being adapted such that said device is coatable within said packaging container. Moreover, the present invention relates to a method of coating the inner surfaces of a packaging container for a device, preferably implants, to be coated by a substance, comprising the steps of (a) siliconizing said inner surfaces of said container using a silicone emulsion, and (b) heat-curing to form a baked-in silicone layer on said inner surfaces of said container.

Abstract: A hypodermic syringe has a hollow body adapted to hold a liquid, an inner cap fitted over an end of the body, and an axially extending needle seated in the inner cap and having an outer point projecting axially outward from the inner cap and an inner point projecting axially inward from the inner cap toward the body. An outer cap fittable over the inner cap and needle is connected to a clamp ring engageable around the inner cap by a frangible web. Interengaging formations on the ring and on the inner cap releasably retain the outer cap in an outer position spaced axially outward of the body and in which an interior of the outer cap is open to the exterior and an inner position spaced axially closely to the body and in which the interior of the outer cap is not open to the exterior.

Abstract: The invention relates to the use of an image-generating photoelectric area sensor 14, for example a CCD sensor, for contact imaging the surface 11 of a biochip 13 by measuring a radiation emitted from the surface of said biochip, such as, for example, chemiluminescence, bioluminescence or fluorescence radiation, and to an image generation method therefor. For this purpose, the biochip 13 is arranged at a distance as short as possible from an area sensor 14. The area sensor 14 is then able, without insertion of an imaging optical system, to detect a spatially resolved two-dimensional image of the radiation emitted from the surface of the functionalized region 12.

Abstract: The invention concerns a freeze-dried emulsion composition containing an active substance and which can be reconstituted using water to give the original emulsion, plus a method for producing the freeze-dried composition. The reconstituted emulsion is suitable for parenteral use.

Abstract: The invention concerns a kit for the preparation of an emulsion containing prostaglandin E.sub.1, a method of preparing the emulsion and a method of preparing the emulsion composition contained in the kit. The emulsion prepared using this kit is suitable for parenteral application.

Abstract: The invention relates to a lyophilized emulsion composition which contains an active substance and which can be redispersed with water to give the original emulsion, and to a process for the preparation thereof.The redispersed emulsion is suitable for parenteral use.