Abstract: A method includes producing filamentary damages in a volume of a glass or glass ceramic element that are adjacently aligned along a separation line and that extend obliquely relative to a surface of the glass or glass ceramic element, and separating a portion from the glass or glass ceramic element along the separation line. The step of producing the filamentary damages includes directing laser pulses of an ultrashort pulse laser obliquely on the surface so that the laser pulses have a light propagation direction that extends obliquely relative to the surface and so that the filamentary damages resulting from the laser pulses have the longitudinal extension that extends obliquely relative to the surface, generating a plasma within the volume with the laser pulses, and displacing the laser pulses at points of incidence over the surface along the separation line.

Abstract: The invention relates to a device for drying and/or for disinfecting objects, comprising a cabinet having a receiving chamber through which a gas can flow, and a fan unit, a heating device being provided for heating the gas. According to the invention, a dehumidifying unit is provided for the condensation drying of the gas, and a gas treatment chamber of the cabinet is provided which, in the installed state of the cabinet, is situated behind the receiving chamber, wherein the gas treatment chamber is separated from the receiving chamber by a partition, the heating device is provided in the gas treatment chamber for heating the gas in the gas treatment chamber, and the heated gas flows from the gas treatment chamber into the receiving chamber.

Abstract: The present invention relates to a method for analysing protein variants of a recombinant protein of interest, such as antibodies or Fc-fusion proteins, in a liquid sample of a mammal. Specifically the method comprises a step of affinity purifying the recombinant protein of interest from the sample together with an internal standard, and analyzing the protein variants using an analytic separating method such as HPLC, capillary electrophoresis or MS. This method is particularly suited to measure pharmacokinetic parameters of a recombinant protein of interest, such as a biopharmaceutical, in a mammal in clinical or pre-clinical studies. It allows for the use of a small sample volume and the possibility to operate with high throughput, such as in a 96-well plate sample preparation. It also provides high sensitivity and allows analysis of protein variants individually.

Abstract: The present invention uses anthranilic acid (2-AA) to label N-glycans prior to separation using a reversed-phase liquid chromatography (RP-LC) column under acidic conditions using formic acid. Negatively charged 2-AA offers stronger retention on the reversed phase column than 2-aminobenzamide (2-AB) in RP-LC and allows efficient ionization and detection of 2-AA labeled N-glycans. The acidic conditions used for the RP-LC leads to an efficient separation of acidic 2-AA N-glycans carrying terminal sialylation without the need for an ion-pairing reagent. The present invention may be used with RP-nano-LC-MS and a 96-well plate sample preparation, which allows attomolar sensitivity and high throughput.

Abstract: The present invention relates to a method for analyzing glycans of a recombinant glycoprotein in a liquid sample of a mammal. Specifically the method comprises a step of affinity purifying the recombinant glycoprotein from the sample, enzymatically releasing a glycan containing fragment from the immobilized glycoprotein, adding a reference standard containing isotopically labeled glycans, fluorescently label the glycans and analyzing the glycans using LC-MS. The present invention also relates to a method further comprising analyzing the glycans of the immobilized recombinant glycoprotein fragment, further comprising a pre-clearing step of the liquid sample, and releasing the glycans from the immobilized recombinant glycoprotein fragment.

Abstract: A method of conveying plastics material pre-forms includes the plastics material pre-forms supplied to a conveying device by a supply device. The conveying device has a first roller body and a second roller body. The plastics material pre-form is conveyed between these roller bodies. A portion of the plastics material pre-forms is supported by the two roller bodies. A further portion of the plastics material pre-forms passes through between the roller bodies. At least one first value characteristic of a state of occupation of the plastics material pre-forms is detected by a first measuring instrument. A second value characteristic is detected by a second measuring instrument downstream of the first measuring instrument in the conveying direction of the plastics material pre-forms. A setting variable of the supply device or the conveying device is controlled on the basis of the two values.

Abstract: An apparatus for the conveying of plastics material containers and, in particular, plastics material pre-forms with a first roller arranged so as to be rotatable about its longitudinal axis, with a second roller arranged so as to be rotatable about its longitudinal axis, wherein the first roller and the second roller are arranged with respect to each other such that the plastics material containers can be conveyed between these rollers, wherein the plastics material container is supported by the two rollers during conveying. At least one roller has a main body produced from a first material and a layer which surrounds this main body in its peripheral direction and which is produced from a plastics material differing from the first material, wherein this layer acts as a contact layer for contacting the plastics material containers.

Abstract: The invention relates to a method of conveying plastics material pre-forms, wherein the plastics material pre-forms are supplied to a conveying device by means of a supply device and the conveying device has a first roller body and a second roller body which extend substantially parallel to each other, and the plastics material pre-form is conveyed between these roller bodies, wherein a portion of the plastics material pre-forms is supported by the two roller bodies and wherein a further portion of the plastics material pre-forms passes through between the roller bodies.

Abstract: An apparatus (1) for the conveying of plastics material pre-forms (10) along a pre-set conveying path (P) with a first guide rail (2) and a second guide rail (4) for guiding the plastics material pre-forms (10), wherein the plastics material pre-forms (10) are guided between the guide rails (2, 4) and the guide rails (2, 4) have in each case first support faces (12, 14) which extend along the conveying path (P) and which support the plastics material pre-forms (10) during the conveying thereof. The apparatus (1) has a stressing device (42, 44) for acting upon the plastics material pre-forms (10) with a gaseous medium. The plastics material pre-forms are conveyed along their conveying path by being acted upon with the gaseous medium, and a geometrical position of the guide rails is capable of being altered with respect to each other.

Abstract: A roll sorter device has a first roll that can be driven rotatably about its roll axis and a second roll that can be driven rotatably about its roll axis opposite the rotation of the first roll. The second roll is arranged spaced from the first roll such that the roll axes of the first and second rolls are arranged substantially parallel to each other. The roll sorter device may include a detection device for detecting seized and/or faulty preforms on the first or second roll and a roll arrangement modification element to modify the arrangement of the first and second rolls to each other when the detection device detects seized preforms. A sorting method for sorting performs and a transport device may employ the aforementioned roll sorter device.

Abstract: A device and a method for orienting objects, in particular preforms for the manufacture of plastic containers, where the preforms are handed over to the entry side of an orientation section via a feeding conveyor, and a discharge means is provided which returns non-oriented preforms via a return feeder. For a constructively simple and quick return, the discharge means is connected directly with the entry side of the orientation section via the return conveyor.

Abstract: An apparatus for the conveying of plastics material containers and, in particular, plastics material pre-forms with a first roller arranged so as to be rotatable about its longitudinal axis, with a second roller arranged so as to be rotatable about its longitudinal axis, wherein the first roller and the second roller are arranged with respect to each other such that the plastics material containers can be conveyed between these rollers, wherein the plastics material container is supported by the two rollers during conveying. At least one roller has a main body produced from a first material and a layer which surrounds this main body in its peripheral direction and which is produced from a plastics material differing from the first material, wherein this layer acts as a contact layer for contacting the plastics material containers.

Abstract: The invention relates to an apparatus and a method for product optimization taking into consideration national and/or international anthropometric or socio-demographic population characteristics, wherein the country specific data (7) (anthropometric or socio-demographic population characteristics) are stored in a central storage device (2) and evaluation queries (10) of the users are carried out via a processor (1), wherein the evaluation queries can be entered via the processor (5) of the user from an arbitrary location by means of communication devices (3, 4) using the communication connection (6). User-specific data for evaluation by the processor (5) can additionally be entered. The results of the evaluation (11) are transmitted to the processor (5) of the user and made available there to the user.

Abstract: A conveyor device for containers having a receiving rail for receiving a neck area of the containers, the containers being held by the receiving rail and are movable within this receiving rail. Guide mechanisms are provided with guide elements that are arranged beneath the receiving rail and guide the movement of the containers. The guide elements are movable in the longitudinal direction of the containers and the movements in the longitudinal direction of the containers of a plurality of different guide elements are mechanically linked to one another.

Abstract: A device and a method for orienting objects, in particular preforms for the manufacture of plastic containers, where the preforms are handed over to the entry side of an orientation section via a feeding conveyor, and a discharge means is provided which returns non-oriented preforms via a return feeder. For a constructively simple and quick return, the discharge means is connected directly with the entry side of the orientation section via the return conveyor.

Abstract: An air conveyor for transporting plastic bottles, in which bottles are driven by applying air, in the area of the bottle openings. In a partial area of the air conveyor, means are provided to apply air to the bottle bodies. These means are arranged such that the bottles are essentially oriented vertically with the openings of the bottles facing upwards and the bottom of the bottles facing downwards.

Abstract: A roll sorter device has a first roll that can be driven rotatably about its roll axis and a second roll that can be driven rotatably about its roll axis opposite the rotation of the first roll. The second roll is arranged spaced from the first roll such that the roll axes of the first and second rolls are arranged substantially parallel to each other. The roll sorter device may include a detection device for detecting seized and/or faulty preforms on the first or second roll and a roll arrangement modification element to modify the arrangement of the first and second rolls to each other when the detection device detects seized preforms. A sorting method for sorting performs and a transport device may employ the aforementioned roll sorter device.

Abstract: An air conveyor for transporting plastic bottles, in which bottles are driven by applying air in the area of the bottle openings. In a partial area of the air conveyor, means are provided to apply air to the bottle bodies. These means are arranged such that the bottles are essentially oriented vertically with the openings of the bottles facing upwards and the bottom of the bottles facing downwards.