Abstract: A bearing arrangement for a steering shaft (10) of a vehicle, having a bearing plate (12) which has an inversion (18) and, at the bottom of the inversion, a bearing seat (14) in which a bearing (16) for the steering shaft (10) is held in such a way that a steering shaft (10) runs obliquely with respect to a plate plane (P) which is defined by the outer edge of the inversion (18), and having an insert (28) which is made from plastic, surrounds the steering shaft (10), and is fitted into the inversion (18), in which the inversion (18) has at least one section (24) with walls which run at right angles with respect to the plate plane (P), and the insert (28) has at least one disk (30, 32) which has a uniform thickness and is fitted into the cross-section of the section (24).

Abstract: A method for producing a component with a sandwich structure, in which at least one essentially flat top layer is produced from a ferrous material, a structure is introduced into an essentially flat intermediate layer composed of a ferrous material, contact regions of the intermediate layer are at least partially galvanized, the at least one top layer and the intermediate layer are superposed to form a composite so that the contact regions rest against the top layer, and the composite is then press hardened. The invention produces an easily recyclable component with a sandwich structure, which has good rigidity and strength properties.

Abstract: A method for producing partially hardened steel components in which a blank composed of a hardenable sheet steel is subjected to a temperature increase and shaped into a component; the component is transferred to a tool in which the heated component is cooled and thus quench hardened; during the heating of the blank or component in order to achieve the temperature increase to a temperature required for the hardening in regions that are to have a lower hardness and/or higher ductility, cooling elements are spaced apart from the surface by a small gap; the cooling element is dimensioned so that the thermal energy acting on the region that remains ductile flows through the component into the cooling element, characterized in that in order to space the cooling element apart from the component, micro-nubs or knobs are used, which are distributed over the area of the cooling element.

Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.

Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.

Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.

Abstract: The invention relates to a method for producing a hardened, steel component with regions of different hardness and/or ductility; a blank is stamped out and either heated in some regions to a temperature ?Ac3, and then transferred to a forming die, is formed, and is cooled at a speed that is greater than the critical hardening speed and thus hardened or is cold formed into the finished shape and the formed blank is heated in some regions to a temperature >Ac3 and then transferred to a hardening die and is hardened at a speed greater than the critical hardening speed; the steel material is adjusted in a transformation-delaying fashion so that a quench hardening through transformation of austenite into martensite takes place at a forming temperature that lies in the range from 450° C. to 700° C.; after the heating and before the forming, an active cooling takes place at >15 K/s.

Abstract: The invention relates to a method for producing a hardened steel component with a coating composed of zinc or a zinc alloy; a blank is stamped out of a sheet coated with the zinc or zinc alloy, the stamped-out blank is heated to a temperature ?Ac3 and if need be, kept at this temperature for a predetermined time in order to induce the formation of austenite, and then the heated blank is transferred to a forming die, is formed in the forming die, and is cooled at a speed that is greater than the critical hardening speed and thus hardened; the steel material is adjusted in a transformation-delaying fashion so that a quench hardening through transformation of austenite into martensite takes place at a forming temperature that lies in the range from 450° C. to 700° C.; after the heating and before the forming, an active cooling takes place at >15K/s.

Abstract: The invention relates to a method for producing partially hardened steel components in which a blank is subjected to a temperature increase that is sufficient for a quench-hardening and after reaching a desired temperature, the blank is transferred to a forming tool in which the blank is quench-hardened or the blank is cold-formed and the component obtained by the cold-forming is then subjected to a temperature increase. During the heating of the blank or component, absorption masses rest against and/or are spaced with a small gap apart from regions that are intended to have a lower hardness and/or higher ductility; with regard to its expansion and thickness, its thermal conductivity, and its thermal capacity and/or with regard to its emissivity, the absorption mass is dimensioned so that the thermal energy acting on the component in the region to remain ductile flows through the component into the absorption mass.

Abstract: The invention relates to a process for producing sheet steel components having regions of differing ductility, in which either a sheet metal plate composed of a hardenable steel alloy is used to produce a component by deep-drawing and the deep-drawn component is then at least partially austenitized by a heat treatment and subsequently quench hardened in a die or the plate is at least partially austenitized by a heat treatment and shaped in the hot state, and is quench hardened during or after this, with the sheet metal plate having a zinc-based cathodic corrosion protection coating, characterized in that in regions of a desired higher ductility of the component, at least one additional sheet is attached to the plate, situated so that during the heat treatment, the plate is heated to a lesser degree there than in the remaining region.

Abstract: The invention relates to a method for producing partially hardened steel components in which a blank is subjected to a temperature increase that is sufficient for a quench-hardening and after reaching a desired temperature, the blank is transferred to a forming tool in which the blank is quench-hardened or the blank is cold-formed and the component obtained by the cold-forming is then subjected to a temperature increase. During the heating of the blank or component, absorption masses rest against and/or are spaced with a small gap apart from regions that are intended to have a lower hardness and/or higher ductility; with regard to its expansion and thickness, its thermal conductivity, and its thermal capacity and/or with regard to its emissivity, the absorption mass is dimensioned so that the thermal energy acting on the component in the region to remain ductile flows through the component into the absorption mass.

Abstract: The present invention relates to new trimethoxyphenyl inhibitors of tyrosine kinase, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: Compounds are disclosed having the general formula R1—X—R2, wherein R1 and R2 are biologically active groups, at least one of which is polypeptidic. X is a non-peptidic polymeric group. R1 and R2 may be the same or different. Preferred R1 and R2 groups are interleukin-1 receptor antagonist, 30 kDa TNF inhibitor, interleukin-2 receptors and CR1 and muteins thereof. Also included are site selectively modified interleukin-1 receptor antagonist and 30 kDa TNF inhibitor.

Abstract: Interleukin-1 inhibitors are provided. Compositions comprising an interleukin-1 inhibitor are provided. Methods of treating a patient comprising administering an interleukin-1 inhibitor are provided.

Abstract: This is a method for treating ophthalmic disorders associated with an excess of IGF-I or IGF-II. The method comprises administering individuals with an IGF excess insulin-like growth factor binding protein (IGFBP). The preferred form is IGFBP-3.

Abstract: The invention provides new methods for the treatment of diabetes mellitus, including type I, type II, and insulin resistant diabetes (both type I and type II). The methods of the invention employ administration of rhIGF-I/IGFBP-3 complex to a subject suffering from the symptoms of diabetes mellitus. Administration of rhIGF-I/IGFBP-3 to a subject suffering from the symptoms of diabetes mellitus results in amelioration or stabilization of the symptoms of diabetes.

Abstract: The present invention involves a method for providing high dose IGF-I therapy by administering a complex of IGF-I and IGFBP-3. The IGF-I/IGFBP-3 complex may be given at unexpectedly high doses without inducing IGF-I-related side effects.

Abstract: The present invention provides a novel method for refolding insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3(IGFBP-3). The method involves mixing of IGF-I and IGFBP-3 together in a cofolding reaction. The inventive cofolding method results in substantially higher yields of correctly folded protein for both molecules and alters the kinetics of refolding. The method includes the production of correctly folded IGF-I, IGFBP-3, and/or IGF-I/IGFBP-3 complex.

Abstract: This is a method for treating catabolic conditions in individuals by administering a composition containing a complex of insulin-like growth factor (IGF) and insulin-like growth factor binding protein-3 (IGFBP-3).

Abstract: This is a method for enhancing systemic tissue repair in patients with burns, trauma and peptic ulcers, as well as patients about to undergo, is undergoing or just having undergone surgery. The method comprises systemically administering to such individuals a therapeutic composition comprising IGF and IGFBP. The preferred form is IGF-I/IGFBP-3.