Abstract: The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.

Abstract: A bearing arrangement for a steering shaft (10) of a vehicle, having a bearing plate (12) which has an inversion (18) and, at the bottom of the inversion, a bearing seat (14) in which a bearing (16) for the steering shaft (10) is held in such a way that a steering shaft (10) runs obliquely with respect to a plate plane (P) which is defined by the outer edge of the inversion (18), and having an insert (28) which is made from plastic, surrounds the steering shaft (10), and is fitted into the inversion (18), in which the inversion (18) has at least one section (24) with walls which run at right angles with respect to the plate plane (P), and the insert (28) has at least one disk (30, 32) which has a uniform thickness and is fitted into the cross-section of the section (24).

Abstract: A method for operating a pressure-regulating valve of a fuel injection system of an internal combustion engine of, in particular, a motor vehicle; the fuel injection system including a pressure reservoir for storing pressurized fuel, as well as a feed device for delivering fuel to the pressure reservoir; and fuel being removable from the pressure reservoir via the pressure-regulating valve. In an overrun mode of the internal combustion engine, a delivery quantity of fuel delivered to the pressure reservoir by the feed device is set to a value greater than zero, and that a fuel pressure in the pressure reservoir is ascertained.

Abstract: A method for producing a component with a sandwich structure, in which at least one essentially flat top layer is produced from a ferrous material, a structure is introduced into an essentially flat intermediate layer composed of a ferrous material, contact regions of the intermediate layer are at least partially galvanized, the at least one top layer and the intermediate layer are superposed to form a composite so that the contact regions rest against the top layer, and the composite is then press hardened. The invention produces an easily recyclable component with a sandwich structure, which has good rigidity and strength properties.

Abstract: A method for determining a value of a current, which is required for changing a switching state of a pressure control valve of a fuel delivery system, in which the current flowing through the pressure control valve is varied from a starting value up to a target value, and a time curve of the current is analyzed, the value required for changing the switching state being reached when the curve of the current has a change in slope, this change being detected via a first derivation over time of the current.

Abstract: A method for producing partially hardened steel components in which a blank composed of a hardenable sheet steel is subjected to a temperature increase and shaped into a component; the component is transferred to a tool in which the heated component is cooled and thus quench hardened; during the heating of the blank or component in order to achieve the temperature increase to a temperature required for the hardening in regions that are to have a lower hardness and/or higher ductility, cooling elements are spaced apart from the surface by a small gap; the cooling element is dimensioned so that the thermal energy acting on the region that remains ductile flows through the component into the cooling element, characterized in that in order to space the cooling element apart from the component, micro-nubs or knobs are used, which are distributed over the area of the cooling element.

Abstract: A method is described for operating a fuel injection system, in particular of an internal combustion engine, in which fuel under pressure is made available in a pressure reservoir and a fuel pressure prevailing in the pressure reservoir is ascertainable with the aid of a pressure sensor. Fuel is removed from the pressure reservoir over a predefinable pressure reduction time period, measured pressure values are ascertained (determined) with the aid of the pressure sensor at least two different points in time during the pressure reduction period, and an actual fuel pressure at the beginning of the pressure reduction period is inferred from the measured pressure values ascertained (determined) during the pressure reduction period.

Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.

Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.

Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.

Abstract: A method for ascertaining an error in a fuel metering unit of an injection system for an internal combustion engine, wherein the gradients of a first signal representing a physical variable and of a second signal representing a physical variable are determined, and at a predefined magnitude and/or direction of the two gradients an error is recognized.

Abstract: The invention relates to a method for producing a hardened, steel component with regions of different hardness and/or ductility; a blank is stamped out and either heated in some regions to a temperature ?Ac3, and then transferred to a forming die, is formed, and is cooled at a speed that is greater than the critical hardening speed and thus hardened or is cold formed into the finished shape and the formed blank is heated in some regions to a temperature >Ac3 and then transferred to a hardening die and is hardened at a speed greater than the critical hardening speed; the steel material is adjusted in a transformation-delaying fashion so that a quench hardening through transformation of austenite into martensite takes place at a forming temperature that lies in the range from 450° C. to 700° C.; after the heating and before the forming, an active cooling takes place at >15 K/s.

Abstract: The invention relates to a method for producing a hardened steel component with a coating composed of zinc or a zinc alloy; a blank is stamped out of a sheet coated with the zinc or zinc alloy, the stamped-out blank is heated to a temperature ?Ac3 and if need be, kept at this temperature for a predetermined time in order to induce the formation of austenite, and then the heated blank is transferred to a forming die, is formed in the forming die, and is cooled at a speed that is greater than the critical hardening speed and thus hardened; the steel material is adjusted in a transformation-delaying fashion so that a quench hardening through transformation of austenite into martensite takes place at a forming temperature that lies in the range from 450° C. to 700° C.; after the heating and before the forming, an active cooling takes place at >15K/s.

Abstract: The invention relates to a method for producing partially hardened steel components in which a blank is subjected to a temperature increase that is sufficient for a quench-hardening and after reaching a desired temperature, the blank is transferred to a forming tool in which the blank is quench-hardened or the blank is cold-formed and the component obtained by the cold-forming is then subjected to a temperature increase. During the heating of the blank or component, absorption masses rest against and/or are spaced with a small gap apart from regions that are intended to have a lower hardness and/or higher ductility; with regard to its expansion and thickness, its thermal conductivity, and its thermal capacity and/or with regard to its emissivity, the absorption mass is dimensioned so that the thermal energy acting on the component in the region to remain ductile flows through the component into the absorption mass.

Abstract: The invention proposes a fuel delivery device for a fuel injection device of an internal combustion engine, having a delivery pump (10) and having at least one high-pressure pump (16). By means of the delivery pump (10), fuel from a storage container (12) is delivered to the suction side of the high-pressure pump (16), and fuel is delivered into a high-pressure region (18) by the high-pressure pump (16). The delivery pump (10) has an adjustable displacement volume, which means that a variable quantity of fuel can be conveyed at the same rotational speed.

Abstract: The invention relates to a process for producing sheet steel components having regions of differing ductility, in which either a sheet metal plate composed of a hardenable steel alloy is used to produce a component by deep-drawing and the deep-drawn component is then at least partially austenitized by a heat treatment and subsequently quench hardened in a die or the plate is at least partially austenitized by a heat treatment and shaped in the hot state, and is quench hardened during or after this, with the sheet metal plate having a zinc-based cathodic corrosion protection coating, characterized in that in regions of a desired higher ductility of the component, at least one additional sheet is attached to the plate, situated so that during the heat treatment, the plate is heated to a lesser degree there than in the remaining region.

Abstract: A method for determining a fuel mass of a single injection that has been injected into at least one combustion chamber of a combustion engine with at least one injection under high pressure. The method includes determining a correction variable for the single injection with the aid of a comparison of a measure for the actual amount of the injected fuel of at least one test injection, which takes place due to a measure for a default nominal amount of a desired single injection, and a measure for the nominal amount of the test injection. The method additionally includes executing a plurality of timely directly successive test injections.

Abstract: A method and a device for controlling a fuel metering system are described. The fuel metering system includes at least one injector for injecting fuel into an internal combustion engine. An electric current value is applied to the at least one injector, and a rail pressure value is determined based on the electric current value.

Abstract: The invention relates to a method for producing partially hardened steel components in which a blank is subjected to a temperature increase that is sufficient for a quench-hardening and after reaching a desired temperature, the blank is transferred to a forming tool in which the blank is quench-hardened or the blank is cold-formed and the component obtained by the cold-forming is then subjected to a temperature increase. During the heating of the blank or component, absorption masses rest against and/or are spaced with a small gap apart from regions that are intended to have a lower hardness and/or higher ductility; with regard to its expansion and thickness, its thermal conductivity, and its thermal capacity and/or with regard to its emissivity, the absorption mass is dimensioned so that the thermal energy acting on the component in the region to remain ductile flows through the component into the absorption mass.