Abstract: The present invention relates to designed ankyrin repeat domains having a reduced isoelectric point (pI) and/or having a reduced number of basic amino acid residues. The invention also provides such repeat domains linked to a drug moiety, for example a radionuclide or a cytotoxic agent. The invention furthermore provides methods for producing such repeat domains, as well as the use of such repeat domains in therapeutic and/or diagnostic methods. In addition, the invention provides recombinant proteins comprising such repeat domains, nucleic acids encoding such repeat domains or recombinant proteins, pharmaceutical compositions comprising such repeat domains, recombinant proteins nucleic acids, recombinant expression vectors and host cells, and the use of such proteins, nucleic acids or pharmaceutical compositions in methods for treating diseases, such as cancer.

Abstract: The invention relates to novel compounds having the general formula Ib wherein R1, R2, R1, R4, R5 and Z are as described herein, composition including the compounds and methods of using the compounds.

Abstract: Disclosed is a method for treating containers, wherein the containers are transported along a predetermined transport path by a transport device and are treated in a predetermined manner by a first treatment device, wherein predetermined working parameters are used for the treatment of the container, wherein individual containers being inspected after their treatment and at least one variable characteristic of a quality of this container being determined, wherein that at least one identification information is generated by an inspected container and/or an inspection operation can be uniquely identified.

Abstract: The invention relates to a transfer press for successive forming and demoulding of work pieces by means of upper and lower tools in dies, wherein the upper tools are attached to a ram head, while the lower tools are installed on a ram foot. The ram head and the ram base are rigidly connected to each other and form a ram.

Abstract: Method for forming plastic preforms into plastic containers, wherein a plastic preform is introduced into a blow mould and is expanded into a plastic container by being applied by a flowable medium, wherein the plastic preform is applied by at least two different pressure levels and wherein furthermore preferably a rod-like body is introduced into the plastic preform, in order to expand the plastic preform in its longitudinal direction, wherein a pressure curve and/or a movement curve of the rod-like body being determined by a measuring device during the expansion process, wherein least one of the curves is evaluated by means of a processor device and at least one point or region of this curve which is characteristic of the course is determined.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for processing images using mixer neural networks. One of the methods includes obtaining one or more images comprising a plurality of pixels; determining, for each image of the one or more images, a plurality of image patches of the image, wherein each image patch comprises a different subset of the pixels of the image; processing, for each image of the one or more images, the corresponding plurality of image patches to generate an input sequence comprising a respective input element at each of a plurality of input positions, wherein a plurality of the input elements correspond to respective different image patches; and processing the input sequences using a neural network to generate a network output that characterizes the one or more images, wherein the neural network comprises one or more mixer neural network layers.

Abstract: A forming unit (20) for forming plastic preforms into plastic bottles, wherein the forming unit comprises a blow mould (20) having a first lateral portion (4), a second lateral portion (6) and a bottom portion (2), wherein said lateral portions as well as the bottom portion (2) form a cavity (15), within which the plastic preforms (10) can be formed into the plastic bottles, wherein the bottom portion (2) can be moved relative to the lateral portions (4) in a closed condition of the blow mould, wherein the forming unit (20) comprises a drive unit in order to move the bottom portion (2) relative to the lateral portions (4, 6), wherein the drive unit preferably has a movable piston element (32) which ist movable along a predefined stroke path.

Abstract: Provided is an apparatus for heating plastic parisons, including a transport device or transporter, which transports the plastic parisons at least in sections along a predefined transport path, wherein the transport device or transporter has a plurality of holding devices or holders for holding the plastic parisons, with a heating device or heaters for heating the plastic parisons at least at times, while they are being transported by the transport device or transporters, wherein the apparatus has at least one heat shielding device or heat shield which is suitable and intended to counteract the heating of mouth regions of the plastic parisons.

Abstract: A method for forming plastic preforms into plastic bottles includes introducing a plastic preform to be expanded into a blow mould, wherein this blow mould has at least two side parts and a bottom part which is movable in a longitudinal direction of the plastic preform in relation to these side parts; introducing a rod-shaped body through a mouth of the plastic preform into the interior of the plastic preform; applying a first pressure to the plastic preform; applying a second pressure to the plastic preform, wherein this second pressure differs from the first pressure and is higher than the first pressure; applying a third pressure to the plastic preform, wherein this third pressure differs from the second pressure and is higher than the second pressure. After applying the third pressure to the plastic preform, the bottom part is moved in the longitudinal direction of the plastic preform towards the latter.

Abstract: The present invention relates to an aqueous dispersion obtained by a process comprising the steps of (a) preparing an acidic copolymer (A) by radical copolymerization of monomers comprising: (a1) at least one unsaturated fatty acid, (a2) at least one ethylenically unsaturated monomer containing at least one acid group or group capable of forming an acid group, (a3) at least one other ethylenically unsaturated monomer different from (a1) and (a2), (b) neutralizing totally or partially the acid groups of copolymer (A) and dissolving it in water, (c) copolymerizing in the solution obtained at step (b) a monomer mixture different from the monomer mixture of step (a) to form a copolymer (B) as well as blends based on such dispersions, especially in combination with oxidatively drying alkyds.

Abstract: A forming unit (20) for forming plastic preforms into plastic bottles, wherein the forming unit comprises a blow mould (20) having a first lateral portion (4), a second lateral portion (6) and a bottom portion (2), wherein said lateral portions as well as the bottom portion (2) form a cavity (15), within which the plastic preforms (10) can be formed into the plastic bottles, wherein the bottom portion (2) can be moved relative to the lateral portions (4) in a closed condition of the blow mould, wherein the forming unit (20) comprises a drive unit in order to move the bottom portion (2) relative to the lateral portions (4, 6), wherein the drive unit preferably has a movable piston element (32) which ist movable along a predefined stroke path.

Abstract: Provided is an apparatus for heating plastic parisons, including a transport device or transporter, which transports the plastic parisons at least in sections along a predefined transport path, wherein the transport device or transporter has a plurality of holding devices or holders for holding the plastic parisons, with a heating device or heaters for heating the plastic parisons at least at times, while they are being transported by the transport device or transporters, wherein the apparatus has at least one heat shielding device or heat shield which is suitable and intended to counteract the heating of mouth regions of the plastic parisons.

Abstract: A method for forming plastic preforms into plastic bottles includes introducing a plastic preform to be expanded into a blow mould, wherein this blow mould has at least two side parts and a bottom part which is movable in a longitudinal direction of the plastic preform in relation to these side parts; introducing a rod-shaped body through a mouth of the plastic preform into the interior of the plastic preform; applying a first pressure to the plastic preform; applying a second pressure to the plastic preform, wherein this second pressure differs from the first pressure and is higher than the first pressure; applying a third pressure to the plastic preform, wherein this third pressure differs from the second pressure and is higher than the second pressure. After applying the third pressure to the plastic preform, the bottom part is moved in the longitudinal direction of the plastic preform towards the latter.

Abstract: Embodiments facilitate the efficient handling of service requests by a Platform-as-a-Service (PaaS) infrastructure. The platform may comprise a central controller communicating with a plurality of execution agents on one or more hosts. The central controller may parse client requests manipulating application state (e.g., scale, start, stop app, clear) into a sequence of fine-grained instance requests (e.g., start, stop, stop all, clear) that are distributed to the application program interfaces (API) of execution agents on the platform. The central controller may assign a priority to the fine-grained requests. The priority may take into consideration one or more factors including but not limited to: request creator (user, system); operation type (start, stop, stop all, clear); instance number; sequence number of the fine grained request within the original received request; hierarchy level (organization, space); and application.

Abstract: A method for transforming plastic preforms into plastic bottles, in which preforms are introduced into blowing stations, each blowing station having at least one blow mold and a stretching rod for stretching the preform along a longitudinal axis of the preform within the blow mold, and the preforms are expanded to form the plastic bottles by being acted upon by a gaseous medium in the blow mold, wherein a wall thickness of the plastic container is measured by at least one measuring device which outputs the measured values to a closed-loop and/or open-loop control device, wherein at least a stretching speed of the stretching rod is varied by the closed-loop and/or open-loop control device at least at times and/or at least in some locations during the blowing operation, individually for each blowing station, in order to adjust a wall thickness of the plastic bottles.

Abstract: The invention relates to a transfer press for successive forming and demoulding of work pieces by means of upper and lower tools in dies, wherein the upper tools are attached to a ram head, while the lower tools are installed on a ram foot. The ram head and the ram base are rigidly connected to each other and form a ram.

Abstract: The present disclosure involves systems, software, and computer implemented methods for remotely debugging applications in a private cloud environment. One example method includes establishing a first secure connection with a client device in response to receiving a request from the client device for a secure debugging session to remotely debug an application instance running in a private cloud environment. A host that is hosting the application instance is identified. A second secure connection is established with the identified host. A request is submitted, over the second secured connection, to the identified host, to instantiate a debug proxy process. The debug proxy process is configured to establish a secure inter-process communication channel with the application instance and instruct the application instance to run in a debug mode.

Abstract: Cleaning machine for timepiece or jewellery components, including cleaning baskets with a receptacle including a bottom and a peripheral partition separating the internal volume of the receptacle, and an environment outside the basket, which includes in the bottom or in the peripheral partition, flared holes whose cross-section is smaller towards the receptacle than towards the external environment, the machine including cleaning means and drying means arranged to circulate cleaning or drying fluids through flow orifices and flared holes, and effluent collecting means arranged to collect effluents from the cleaning and drying operations.

Abstract: Embodiments facilitate the efficient handling of service requests by a Platform-as-a-Service (PaaS) infrastructure. The platform may comprise a central controller communicating with a plurality of execution agents on one or more hosts. The central controller may parse client requests manipulating application state (e.g., scale, start, stop app, clear) into a sequence of fine-grained instance requests (e.g., start, stop, stop all, clear) that are distributed to the application program interfaces (API) of execution agents on the platform. The central controller may assign a priority to the fine-grained requests. The priority may take into consideration one or more factors including but not limited to: request creator (user, system); operation type (start, stop, stop all, clear); instance number; sequence number of the fine grained request within the original received request; hierarchy level (organization, space); and application.

Abstract: The present disclosure involves systems, software, and computer implemented methods for monitoring processes running on a platform as a service architecture. One example method includes storing a received sample of monitored attributes of a computer process in a sample memory buffer that includes other stored samples. A determination is made that the sample memory buffer is full. The sample memory buffer is compressed. A starting position in a compressed sample file store at which to store the compressed sample memory buffer is determined. The compressed sample memory buffer is stored at the determined starting position in the compressed sample file store. The starting position of the stored compressed sample memory buffer is stored at a particular location in a file position index. A collection timestamp for the sample in a timestamp index is stored at a timestamp index location that matches the particular location in the file position index.