Patents by Inventor Andreas Stengl

Andreas Stengl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHEMOSELECTIVE THIOL-CONJUGATION WITH ALKENE OR ALKYNE-PHOSPHONAMIDATES
    Publication number: 20250090672
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof.
    Type: Application
    Filed: November 26, 2024
    Publication date: March 20, 2025
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl
  • NOVEL FLT3 ANTIBODIES AND ANTIBODY-DRUG-CONJUGATES BASED THEREON, THERAPEUTIC METHODS AND USES THEREOF IN COMBINATION WITH TYROSINE KINASE INHIBITORS
    Publication number: 20250049939
    Abstract: The present invention relates to novel anti-FLT3 antibodies for specifically targeting extracellular domain of FLT3. The present invention further relates to targeting FLT3 by novel antibody-drug-conjugates (ADCs) based on the novel anti-FLT3 antibodies of the present invention, especially in combination with kinase inhibitors, for use in therapy and/or for use in a method of cancer treatment (e.g., acute myeloid leukemia (AML) with or without internal tandem duplication (ITD) mutations in the FLT3 gene (FLT3-ITD)).
    Type: Application
    Filed: December 12, 2022
    Publication date: February 13, 2025
    Inventors: Heinrich LEONHARDT, Andreas STENGL, Maike ROAS, Jonathan SCHWACH, Karsten SPIEKERMANN, Harald POLZER, Marina ABLE, Jonas HELMA-SMETS, Dominik SCHUMACHER, Marcus GERLACH, Christian Peter Richard HACKENBERGER, Marc-André KASPER, Irmela JEREMIAS, Binje VICK, Elisabeth KREMMER
  • Chemoselective thiol-conjugation with alkene or alkyne-phosphonamidates
    Patent number: 12171837
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof.
    Type: Grant
    Filed: July 10, 2023
    Date of Patent: December 24, 2024
    Assignees: FORSCHUNGSVERBUND BERLIN E.V., LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl
  • CHEMOSELECTIVE THIOL-CONJUGATION WITH ALKENE OR ALKYNE-PHOSPHONAMIDATES
    Publication number: 20230348529
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof.
    Type: Application
    Filed: July 10, 2023
    Publication date: November 2, 2023
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl
  • Chemoselective thiol-conjugation with alkene or alkyne-phosphonamidates
    Patent number: 11746124
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: September 5, 2023
    Assignees: FORSCHUNGSVERBUND BERLIN E.V., LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl
  • CHEMOSELECTIVE THIOL-CONJUGATION WITH ALKENE OR ALKYNE-PHOSPHONAMIDATES
    Publication number: 20220106356
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof.
    Type: Application
    Filed: August 30, 2021
    Publication date: April 7, 2022
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl
  • Chemoselective thiol-conjugation with alkene or alkyne-phosphonamidates
    Patent number: 11161873
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof. A process tor the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV), to prepare a compound of formula (V), reacting a compound of formula (V) with a thiol-containing molecule of formula (VI), resulting in a compound of formula (VII).
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: November 2, 2021
    Assignees: FORSCHUNGSVERBUND BERLIN E.V., LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl
  • A DOUBLE PEPTIDE TAG COMBINING REVERSIBILITY AND FLEXIBLE FUNCTIONALIZATION
    Publication number: 20210246189
    Abstract: The present invention relates to a peptide comprising a reversible affinity tag (A); and a functionalization tag (F), wherein the peptide is linked to a target of interest (T). The peptide is useful as a versatile protein tag. The invention further provides structures comprising the peptide, nucleic acids, vectors, and host cells. Further, the invention provides methods of producing or using the peptide.
    Type: Application
    Filed: August 30, 2019
    Publication date: August 12, 2021
    Applicants: TECHNISCHE UNIVERSITAET MUENCHEN, LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
    Inventors: Dirk BUSCH, Manuel EFFENBERGER, Heinrich LEONHARDT, Andreas STENGL
  • CHEMOSELECTIVE THIOL-CONJUGATION WITH ALKENE OR ALKYNE-PHOSPHONAMIDATES
    Publication number: 20190330264
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof. A process for the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV), to prepare a compound of formula (V), reacting a compound of formula (V) with a thiol-containing molecule of formula (VI), resulting in a compound of formula (VII).
    Type: Application
    Filed: September 1, 2017
    Publication date: October 31, 2019
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl