Patents by Inventor Andreas Striebinger

Andreas Striebinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMYLOID-BETA BINDING PROTEINS
    Publication number: 20140227291
    Abstract: The present invention relates to amyloid-beta (A?) binding proteins. Antibodies of the invention have high affinity to A?(20-42) globulomer or any A? form that comprises the globulomer epitope. Method of making and method of using the antibodies of the invention are also provided.
    Type: Application
    Filed: August 12, 2011
    Publication date: August 14, 2014
    Inventors: Stefan Barghorn, Heinz Hillen, Andreas Striebinger, Simone Giasi, Ulrich Ebert, Chung-Ming Hsieh
  • AMYLOID BETA(1-42) OLIGOMERS, DERIVATIVES THEREOF AND ANTIBODIES THERETO, METHODS OF PREPARATION THEREOF AND USE THEREOF
    Publication number: 20120034166
    Abstract: The invention relates to neuromodulatory oligomers of the amyloid-?(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-?(1-42) proteins, the production and use thereof.
    Type: Application
    Filed: August 1, 2011
    Publication date: February 9, 2012
    Inventors: Heinz Hillen, Andreas Striebinger, Carsten Krantz, Achim Moeller, Reinhold Mueller
  • AMYLOID-BETA BINDING PROTEINS
    Publication number: 20110256138
    Abstract: The present invention relates to amyloid-beta (A?) binding proteins. Antibodies of the invention have high affinity to A?(20-42) globulomer or any A? form that comprises the globulomer epitope. Method of making and method of using the antibodies of the invention are also provided.
    Type: Application
    Filed: April 13, 2011
    Publication date: October 20, 2011
    Applicants: ABBOTT LABORATORIES, ABBOTT GMBH & CO. KG
    Inventors: Stefan Barghorn, Heinz Hillen, Andreas Striebinger, Simone Giaisi, Ulrich Ebert, Lorenzo Benatuil
  • Amyloid ?(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
    Patent number: 7902328
    Abstract: The invention relates to neuromodulatory oligomers of the amyloid-?(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-?(1-42) proteins, the production and use thereof.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: March 8, 2011
    Assignee: Abbott Laboratories
    Inventors: Heinz Hillen, Andreas Striebinger
  • AMYLOID BETA(1-42) OLIGOMERS, DERIVATIVES THEREOF AND ANTIBODIES THERETO, METHODS OF PREPARATION THEREOF AND USE THEREOF
    Publication number: 20100209346
    Abstract: The invention relates to neuromodulatory oligomers of the amyloid ?(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers and diagnostic and therapeutic agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof.
    Type: Application
    Filed: September 14, 2009
    Publication date: August 19, 2010
    Inventors: Heinz Hillen, Andreas Striebinger, Carsten Krantz, Achim Moeller, Reinhold Mueller
  • Aß(X - 38 .. 43) oligomers, and processes, compositions, and uses thereof
    Publication number: 20100173828
    Abstract: The present invention relates to an A?(X-38 . . . 43) oligomer having a high molecular weight, or a derivative thereof, a process for preparing the oligomer or derivative, compositions comprising the oligomer or derivative, and uses of the oligomer or derivative such as its use for treating or preventing an amyloidosis (e.g. by active immunization), for diagnosing an amyloidosis, and for providing agents that are capable of binding to the A?(X-38 . . . 43) oligomer or derivative. The subject invention also describes agents that are capable of binding to the A?(X-38 . . . 43) oligomer or derivative, e.g. antibodies, compositions comprising the agents, and uses of the agents such as their use for treating or preventing an amyloidosis (e.g. by passive immunization) and for diagnosing an amyloidosis.
    Type: Application
    Filed: July 24, 2009
    Publication date: July 8, 2010
    Applicant: ABBOTT GmbH & Co. KG
    Inventors: Heinz Hillen, Andreas Striebinger, Simone Giaisi, Stefan Barghorn, Gerald Gellermann, Ulrich Ebert, Joerg Moelleken
  • Screening Method, Process for Purifying of Non-Diffusible A-Beta Oligomers, Selective Antibodies Against Said Non-Diffusible a-Beta Oligomers and a Process for Manufacturing of Said Antibodies
    Publication number: 20090035295
    Abstract: The present invention is relates to non-diffusible globular A?(X-38 . . . 43) oligomers (“globulomers”) or derivatives thereof, methods for enriching said globulomers or derivatives, compositions comprising said globulomers or derivatives, antibodies and aptamers having specificity for said globulomers or derivatives, methods for preparing such antibodies and aptamers, uses of said globulomers or derivatives, or of said antibodies or aptamers for diagnostic, therapeutic and other purposes, and corresponding methods using said globulomers or derivatives, or said antibodies or aptamers.
    Type: Application
    Filed: March 3, 2006
    Publication date: February 5, 2009
    Inventors: Heinz Hillen, Andreas Striebinger, Patrick Keller, Stefan Barghorn, Ulrich Ebert
  • Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
    Publication number: 20070098721
    Abstract: The invention relates to neuromodulatory oligomers of the amyloid-?(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-?(1-42) proteins, the production and use thereof.
    Type: Application
    Filed: February 2, 2004
    Publication date: May 3, 2007
    Inventors: Heinz Hillen, Andreas Striebinger, Carsten Krantz, Achim Moeller, Reinhold Mueller