Abstract: The present invention relates to novel high-value polycarbonate polyols, to processes for the production thereof, to polyisocyanate prepolymers obtainable therefrom and also polyurethane (PUR) and polyurethane urea elastomers which under particularly demanding applications show unique combinations of processing characteristics, hydrolysis and oxidation stability, mechanical and dynamic mechanical properties.

Abstract: The present invention relates to a setting device for fastening a functional element to a workpiece, in particular to a sheet metal component. The setting device comprises a die for receiving and supporting the workpiece and a setting head having a setting die which cooperates with the functional element and by which the functional element can be fastened to the workpiece in an axial setting movement. The setting device further comprises a checking device for determining the quality of a connection of the functional element to the workpiece, wherein the checking device has a sensor having a first contact section, which can be electrically conductively contacted with the functional element, and having a second contact section that can be electrically conductively contacted with the workpiece. The present invention furthermore relates to a corresponding method of fastening a functional element to a workpiece.

Abstract: The present disclosure provides for methods for preparing tricyclic PI3K inhibitor compounds in high yield and purity in aqueous solvent systems.

Abstract: The present disclosure provides for methods for preparing tricyclic PI3K inhibitor compounds in high yield and purity in aqueous solvent systems.

Abstract: The present invention relates to novel high-value polycarbonate polyols, to processes for the production thereof, to polyisocyanate prepolymers obtainable therefrom and also polyurethane (PUR) and polyurethane urea elastomers which under particularly demanding applications show unique combinations of processing characteristics, hydrolysis and oxidation stability, mechanical and dynamic mechanical properties.

Abstract: A manufacturing process to a bis-mesylate salt 1b of the pan-RAF inhibitor 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide. The process features a number of efficient key reactions, including a robust and scalable Pd-catalyzed carbonylation reaction to generate thienopyrimidine 2 and a highly chemoselective PtN/C-catalyzed nitro group reduction to access penultimate intermediate 7. The final amide coupling of 7 and 2 was accomplished by a mild and safe protocol employing N,N,N?,N?-tetramethylchloroformamidinium hexafluorophosphate (TCFH) as the coupling reagent, to produce a 1:1 adduct of the freebase and THF. The adduct afforded compound 1b with excellent yield, purity, and form stability on a multikilogram production scale after reaction with MsOH and recrystallization. The methods are able to produce a compound having upwards of 95% purity.

Abstract: An arrangement for a sensor system for vehicles, in particular motor vehicles, for detecting the vehicle speed, the vehicle level and/or the state of the vehicle suspension, having a sensor for measuring the level of a point on a vehicle body and a vibration damper, the vibration damper comprising a first part and a second part which are movable relative to each other, and wherein the level sensor has an excitation coil, at least one receiver coil and at least one electrically conductive element, wherein the excitation coil and the at least one receiver coil are arranged on the second part of the vibration damper and the electrically conductive element is arranged on the first part of the vibration damper or the first part comprises or forms the electrically conductive element.

Abstract: The present disclosure provides for methods for preparing tricyclic PI3K inhibitor compounds in high yield and purity in aqueous solvent systems.

Abstract: The present disclosure provides for methods for preparing tricyclic PI3K inhibitor compounds in high yield and purity in aqueous solvent systems.

Abstract: The invention relates to elastomer sandwich systems containing at least two components, wherein one component is (i) a thermoplastic polyurethane functioning as a cover layer and, adhering thereto over its area, the second component is (ii) a noncellular cast polyurethane having a density of from 800 to 1800 kg/m3 functioning as a carrier layer, wherein at least one component of the elastomer sandwich system has a tear propagation resistance in accordance with ISO 34-1 of from 30 kN/m to 85 kN/m and an abrasion loss in accordance with ISO 4649 of from 50 mm3 to 5 mm3 and in addition at least the two components have a rebound resilience in accordance with DIN 53512 of 35%-70%, and a process for the production thereof. The invention further relates to metal composite elements containing elastomer sandwich systems, a process for the production thereof and the use thereof as lining elements in the transport sector and mining and mine sector, in particular in hoppers and conveyor belts.

Abstract: The present disclosure provides for methods for preparing tricyclic PI3K inhibitor compounds in high yield and purity in aqueous solvent systems.

Abstract: Disclosed are methods for making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of trichoroisocyanuric acid, a compound of formula R1SR2 and a base. In one embodiment, the alcohol is a compound of formula (I): wherein R3 is a protecting group.

Abstract: Disclosed are methods for making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of trichoroisocyanuric acid, a compound of formula R1SR2 and a base. In one embodiment, the alcohol is a compound of formula (I): wherein R3 is a protecting group. Also disclosed are methods for making 3-O-protected morphine dienol carboxylates comprising allowing a compound of formula (I) to oxidize in the presence of a chlorine-containing compound and a compound of formula R1SR2; and allowing the product of the oxidation step to react with an acylating agent.

Abstract: A method for reducing signal distortion in the transmission of binary coded signals in a motor vehicle, preferably in a power interface, is characterized in that an edge of the binary coded signal is formed in the transmitter by adapting the frequency and phase response of a harmonic such that the signal distortion to be expected on the entire transmission line can be compensated.

Abstract: Disclosed are methods for making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of trichoroisocyanuric acid, a compound of formula R1SR2 and a base. In one embodiment, the alcohol is a compound of formula (I): wherein R3 is a protecting group. Also disclosed are methods for making 3-O-protected morphine dienol carboxylates comprising allowing a compound of formula (I) to oxidize in the presence of a chlorine-containing compound and a compound of formula R1SR2; and allowing the product of the oxidation step to react with an acylating agent.

Abstract: Disclosed are methods for making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of trichoroisocyanuric acid, a compound of formula R1SR2 and a base. In one embodiment, the alcohol is a compound of formula (I): wherein R3 is a protecting group. Also disclosed are methods for making 3-O-protected morphine dienol carboxylates comprising allowing a compound of formula (I) to oxidize in the presence of a chlorine-containing compound and a compound of formula R1SR2; and allowing the product of the oxidation step to react with an acylating agent.

Abstract: A method for reducing signal distortion in the transmission of binary coded signals in a motor vehicle, preferably in a power interface, is characterized in that an edge of the binary coded signal is formed in the transmitter by adapting the frequency and phase response of a harmonic such that the signal distortion to be expected on the entire transmission line can be compensated.

Abstract: Disclosed are methods for making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of trichoroisocyanuric acid, a compound of formula R1SR2 and a base. In one embodiment, the alcohol is a compound of formula (I): wherein R3 is a protecting group. Also disclosed are methods for making 3-O-protected morphine dienol carboxylates comprising allowing a compound of formula (I) to oxidize in the presence of a chlorine-containing compound and a compound of formula R1SR2; and allowing the product of the oxidation step to react with an acylating agent.

Abstract: Disclosed are methods for making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of trichoroisocyanuric acid, a compound of formula R1SR2 and a base. In one embodiment, the alcohol is a compound of formula (I): wherein R3 is a protecting group. Also disclosed are methods for making 3-O-protected morphine dienol carboxylates comprising allowing a compound of formula (I) to oxidize in the presence of a chlorine-containing compound and a compound of formula R1SR2; and allowing the product of the oxidation step to react with an acylating agent.

Abstract: Disclosed are methods for making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of trichoroisocyanuric acid, a compound of formula R1SR2 and a base. In one embodiment, the alcohol is a compound of formula (I): wherein R3 is a protecting group. Also disclosed are methods for making 3-O-protected morphine dienol carboxylates comprising allowing a compound of formula (I) to oxidize in the presence of a chlorine-containing compound and a compound of formula R1SR2; and allowing the product of the oxidation step to react with an acylating agent.